Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis

Fibrocytes are circulating mesenchymal precursors (CD45+, col 1+) recruited to fibrotic areas. Fibrocytes secrete profibrotic mediators including periostin; a matricellular protein that regulates cellular interactions with extracellular matrix (ECM) components. In bleomycin-induced fibrosis, periost...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mucosal immunology 2017-03, Vol.10 (2), p.341-351
Hauptverfasser:	Ashley, S L, Wilke, C A, Kim, K K, Moore, B B
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/347 631/80/86 692/699/1785 Adoptive Transfer Allergology Animals Antibodies article-report Biomedical and Life Sciences Biomedicine Bleomycin Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Differentiation Cells, Cultured Collagen - metabolism Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Disease Models, Animal Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gastroenterology Immunology Integrin beta1 - metabolism Lung - metabolism Lung - pathology Mesenchymal Stem Cells - physiology Mice Mice, Inbred C57BL Mice, Knockout Myofibroblasts - physiology Protein-Lysine 6-Oxidase - genetics Protein-Lysine 6-Oxidase - metabolism Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!