Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats
The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and s...
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Veröffentlicht in: | BMC genomics 2016-12, Vol.17 (Suppl 14), p.989-989, Article 989 |
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description | The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.
The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hypertension development in the ISIAH rats. Two of these were transcription factor genes (Nr4a3 and Ppard), which may be related to the predominant activation of the sympathetic-adrenal medullary axis in ISIAH rats. The other genes are known as associated with hypertension and were defined in the current study as DEGs making the most significant contribution to the inter-strain differences. Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and inflammation in the ISIAH rats.
The study strongly highlighted the complex nature of the pathogenesis of stress-sensitive hypertension. The data obtained may be useful for identifying the common molecular determinants in different animal models of arterial hypertension, which may be potentially used as therapeutic targets for pharmacological intervention. |
doi_str_mv | 10.1186/s12864-016-3354-2 |
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The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hypertension development in the ISIAH rats. Two of these were transcription factor genes (Nr4a3 and Ppard), which may be related to the predominant activation of the sympathetic-adrenal medullary axis in ISIAH rats. The other genes are known as associated with hypertension and were defined in the current study as DEGs making the most significant contribution to the inter-strain differences. Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and inflammation in the ISIAH rats.
The study strongly highlighted the complex nature of the pathogenesis of stress-sensitive hypertension. The data obtained may be useful for identifying the common molecular determinants in different animal models of arterial hypertension, which may be potentially used as therapeutic targets for pharmacological intervention.</description><identifier>ISSN: 1471-2164</identifier><identifier>EISSN: 1471-2164</identifier><identifier>DOI: 10.1186/s12864-016-3354-2</identifier><identifier>PMID: 28105924</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adrenal glands ; Adrenal Glands - metabolism ; Adrenal Glands - physiopathology ; Animals ; Computational Biology - methods ; Development and progression ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Genetic aspects ; Hypertension ; Hypertension - etiology ; Hypertension - metabolism ; Hypertension - physiopathology ; Male ; Physiological aspects ; Rats ; RNA sequencing ; Stress, Physiological ; Transcription (Genetics) ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcriptome</subject><ispartof>BMC genomics, 2016-12, Vol.17 (Suppl 14), p.989-989, Article 989</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-2a551e4e27599ca35bdb53e5f6824efe4ddbcf4070f368b44118daaa517721073</citedby><cites>FETCH-LOGICAL-c500t-2a551e4e27599ca35bdb53e5f6824efe4ddbcf4070f368b44118daaa517721073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249038/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249038/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28105924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fedoseeva, Larisa A</creatorcontrib><creatorcontrib>Klimov, Leonid O</creatorcontrib><creatorcontrib>Ershov, Nikita I</creatorcontrib><creatorcontrib>Alexandrovich, Yury V</creatorcontrib><creatorcontrib>Efimov, Vadim M</creatorcontrib><creatorcontrib>Markel, Arcady L</creatorcontrib><creatorcontrib>Redina, Olga E</creatorcontrib><title>Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats</title><title>BMC genomics</title><addtitle>BMC Genomics</addtitle><description>The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.
The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hypertension development in the ISIAH rats. Two of these were transcription factor genes (Nr4a3 and Ppard), which may be related to the predominant activation of the sympathetic-adrenal medullary axis in ISIAH rats. The other genes are known as associated with hypertension and were defined in the current study as DEGs making the most significant contribution to the inter-strain differences. Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and inflammation in the ISIAH rats.
The study strongly highlighted the complex nature of the pathogenesis of stress-sensitive hypertension. The data obtained may be useful for identifying the common molecular determinants in different animal models of arterial hypertension, which may be potentially used as therapeutic targets for pharmacological intervention.</description><subject>Adrenal glands</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenal Glands - physiopathology</subject><subject>Animals</subject><subject>Computational Biology - methods</subject><subject>Development and progression</subject><subject>Disease Models, Animal</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Gene Ontology</subject><subject>Genetic aspects</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Physiological aspects</subject><subject>Rats</subject><subject>RNA sequencing</subject><subject>Stress, Physiological</subject><subject>Transcription (Genetics)</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptome</subject><issn>1471-2164</issn><issn>1471-2164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkl1rFDEYhQdRbK3-AG8k4I1eTJvP-bgRltKPhUrB6nXIJG9mIzPJmmSK_fdm2bZ0QXKRvMlzDuRwquojwaeEdM1ZIrRreI1JUzMmeE1fVceEt6SmpOGvX5yPqncp_caYtB0Vb6sj2hEsesqPK_89TKCXSUVkIEOcnVc-JxQsyhtAykTwakLjpLxBdvE6u-CdH1GESWUwKAeUcoSU6gQ-uezuAW0ethDzbgweOY_Wd-vVNYoqp_fVG6umBB8e95Pq1-XFz_Pr-ub2an2-uqm1wDjXVAlBgANtRd9rxcRgBsFA2KajHCxwYwZtOW6xZU03cF7iMEopQdqWEtyyk-rb3ne7DDMYDT5HNcltdLOKDzIoJw9fvNvIMdxLQXmPWVcMvjwaxPBngZTl7JKGqeQAYUmyxE9E1_QdK-jnPTqqCaTzNhRHvcPlireCcVbAQp3-hyrLwOx08GBduT8QfD0QFCbD3zyqJSW5vvtxyJI9q2NIKYJ9_inBclcVua-KLFWRu6pIWjSfXkb0rHjqBvsHGL-6Lg</recordid><startdate>20161228</startdate><enddate>20161228</enddate><creator>Fedoseeva, Larisa A</creator><creator>Klimov, Leonid O</creator><creator>Ershov, Nikita I</creator><creator>Alexandrovich, Yury V</creator><creator>Efimov, Vadim M</creator><creator>Markel, Arcady L</creator><creator>Redina, Olga E</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161228</creationdate><title>Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats</title><author>Fedoseeva, Larisa A ; Klimov, Leonid O ; Ershov, Nikita I ; Alexandrovich, Yury V ; Efimov, Vadim M ; Markel, Arcady L ; Redina, Olga E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-2a551e4e27599ca35bdb53e5f6824efe4ddbcf4070f368b44118daaa517721073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adrenal glands</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenal Glands - physiopathology</topic><topic>Animals</topic><topic>Computational Biology - methods</topic><topic>Development and progression</topic><topic>Disease Models, Animal</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Gene Ontology</topic><topic>Genetic aspects</topic><topic>Hypertension</topic><topic>Hypertension - etiology</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Physiological aspects</topic><topic>Rats</topic><topic>RNA sequencing</topic><topic>Stress, Physiological</topic><topic>Transcription (Genetics)</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fedoseeva, Larisa A</creatorcontrib><creatorcontrib>Klimov, Leonid O</creatorcontrib><creatorcontrib>Ershov, Nikita I</creatorcontrib><creatorcontrib>Alexandrovich, Yury V</creatorcontrib><creatorcontrib>Efimov, Vadim M</creatorcontrib><creatorcontrib>Markel, Arcady L</creatorcontrib><creatorcontrib>Redina, Olga E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fedoseeva, Larisa A</au><au>Klimov, Leonid O</au><au>Ershov, Nikita I</au><au>Alexandrovich, Yury V</au><au>Efimov, Vadim M</au><au>Markel, Arcady L</au><au>Redina, Olga E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats</atitle><jtitle>BMC genomics</jtitle><addtitle>BMC Genomics</addtitle><date>2016-12-28</date><risdate>2016</risdate><volume>17</volume><issue>Suppl 14</issue><spage>989</spage><epage>989</epage><pages>989-989</pages><artnum>989</artnum><issn>1471-2164</issn><eissn>1471-2164</eissn><abstract>The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.
The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hypertension development in the ISIAH rats. Two of these were transcription factor genes (Nr4a3 and Ppard), which may be related to the predominant activation of the sympathetic-adrenal medullary axis in ISIAH rats. The other genes are known as associated with hypertension and were defined in the current study as DEGs making the most significant contribution to the inter-strain differences. Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and inflammation in the ISIAH rats.
The study strongly highlighted the complex nature of the pathogenesis of stress-sensitive hypertension. The data obtained may be useful for identifying the common molecular determinants in different animal models of arterial hypertension, which may be potentially used as therapeutic targets for pharmacological intervention.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28105924</pmid><doi>10.1186/s12864-016-3354-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adrenal glands Adrenal Glands - metabolism Adrenal Glands - physiopathology Animals Computational Biology - methods Development and progression Disease Models, Animal Gene Expression Profiling Gene Expression Regulation Gene Ontology Genetic aspects Hypertension Hypertension - etiology Hypertension - metabolism Hypertension - physiopathology Male Physiological aspects Rats RNA sequencing Stress, Physiological Transcription (Genetics) Transcription Factors - genetics Transcription Factors - metabolism Transcriptome |
title | Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats |
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