Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2

Sarcoidosis is characterized by noncaseating granulomas with an unknown cause that present primarily in the lung. Propionibacterium acnes, an immunogenic commensal skin bacterium involved in acne vulgaris, has been implicated as a possible causative agent of sarcoidosis. Here, we demonstrate that a...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2017-01, Vol.56 (1), p.121-130
Hauptverfasser:	Werner, Jessica L, Escolero, Sylvia G, Hewlett, Jeff T, Mak, Tim N, Williams, Brian P, Eishi, Yoshinobu, Núñez, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Bacteria Disease Models, Animal Granuloma - metabolism Granuloma - microbiology Granuloma - pathology Inflammation Mediators - metabolism Lung - microbiology Lung - pathology Lungs Lymphatic system Membrane Glycoproteins - deficiency Membrane Glycoproteins - metabolism Mice, Inbred C57BL Microbial Viability Myeloid Differentiation Factor 88 - deficiency Myeloid Differentiation Factor 88 - metabolism NADPH Oxidase 2 NADPH Oxidases - deficiency NADPH Oxidases - metabolism Neutrophils Neutrophils - metabolism Original Research Patients Propionibacterium acnes Propionibacterium acnes - physiology Reactive Oxygen Species - metabolism Rodents Sarcoidosis Sarcoidosis, Pulmonary - microbiology Sarcoidosis, Pulmonary - pathology Software Studies Trachea - microbiology Variance analysis
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