Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Food-grade titanium dioxide (TiO 2 ) containing a nanoscale particle fraction (TiO 2 -NPs) is approved as a white pigment (E171 in Europe) in common foodstuffs, including confectionary. There are growing concerns that daily oral TiO 2 -NP intake is associated with an increased risk of chronic intest...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.40373, Article 40373
Hauptverfasser:	Bettini, Sarah, Boutet-Robinet, Elisa, Cartier, Christel, Coméra, Christine, Gaultier, Eric, Dupuy, Jacques, Naud, Nathalie, Taché, Sylviane, Grysan, Patrick, Reguer, Solenn, Thieriet, Nathalie, Réfrégiers, Matthieu, Thiaudière, Dominique, Cravedi, Jean-Pierre, Carrière, Marie, Audinot, Jean-Nicolas, Pierre, Fabrice H., Guzylack-Piriou, Laurence, Houdeau, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 14 14/19 692/4020 692/499 Autoimmune diseases Carcinogenesis Colon Colorectal cancer Colorectal carcinoma Dendritic cells Food Helper cells Homeostasis Humanities and Social Sciences Immunoregulation Inflammation Interferon Intestine Lesions Lymphocytes T multidisciplinary Peyer's patches Risk assessment Rodents Science Science (multidisciplinary) Spleen Titanium Titanium dioxide
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