Per2 participates in AKT-mediated drug resistance in A549/DDP lung adenocarcinoma cells

Period2 (Per2) is a key mammalian circadian clock protein, and additionally has a tumor suppressive function. The present study aimed to investigate its role in drug resistance in A549/cisplatin (DDP) lung adenocarcinoma cells. Per2 knockdown and overexpression in A549/DDP cells were used to compare...

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Veröffentlicht in:	Oncology letters 2017-01, Vol.13 (1), p.423-428
Hauptverfasser:	Chen, Bo, Tan, Yaoxi, Liang, Yan, Li, Yan, Chen, Lei, Wu, Shuangshuang, Xu, Wei, Wang, Yan, Zhao, Weihong, Wu, Jianqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis Breast cancer Cell cycle Cellular proteins chemoresistance Circadian rhythm Development and progression Drug resistance Drug therapy Gene expression Genetic aspects Health aspects Immunoglobulins Kinases Lung cancer Oncology period2 phosphoinositide 3-kinase/AKT/mechanistic target of rapamycin Phosphorylation Proteins Studies
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