RNA-Seeded Functional Amyloids Balance Growth and Survival

RNA-Seeded Functional Amyloids Balance Growth and Survival

In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic pr...

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Veröffentlicht in:Developmental cell 2016-10, Vol.39 (2), p.131-132
Hauptverfasser: Lyons, Shawn M., Anderson, Paul
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Amyloid
RNA
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description In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition. In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition.
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subjects Amyloid
RNA
title RNA-Seeded Functional Amyloids Balance Growth and Survival
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