History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection
Background: We aimed to assess the connection between chronic inflammatory disorders (CIDs) and Merkel cell carcinoma (MCC). Methods: Merkel cell carcinoma cases diagnosed in 1978–2009 were extracted from the Finnish Cancer Registry and controls from the Population Registry. Information on reimburse...
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| Veröffentlicht in: | British journal of cancer 2017-01, Vol.116 (2), p.260-264 |
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| creator | Sahi, Helka Sihto, Harri Artama, Miia Koljonen, Virve Böhling, Tom Pukkala, Eero |
| description | Background:
We aimed to assess the connection between chronic inflammatory disorders (CIDs) and Merkel cell carcinoma (MCC).
Methods:
Merkel cell carcinoma cases diagnosed in 1978–2009 were extracted from the Finnish Cancer Registry and controls from the Population Registry. Information on reimbursed CIDs was linked to clinicopathological data including Merkel cell polyomavirus (MCV) status by qPCR and immunohistochemistry for the large T antigen of MCV (LTA), Ki-67 and tumour-infiltrating lymphocytes.
Results:
Chronic inflammatory disorders increased the risk of MCC significantly (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.03–1.88), specifically connective tissue/systemic diseases (OR 1.75, 95% CI 1.09–1.80) and diabetic conditions (OR 1.51, 95% CI 1.03–2.22). Chronic inflammatory disorders associated with larger tumour diameter (
P
=0.02) and higher Ki-67 expression (
P
=0.005). The expression of LTA was seen significantly more often in the absence of CIDs (
P
=0.05).
Conclusions:
Patients with CID are at significantly higher risk for aggressive MCC. Merkel cell polyomavirus positivity is more common in MCC patients unafflicted by CID. |
| doi_str_mv | 10.1038/bjc.2016.391 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5243985</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4303589661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-ca2a8465eb7b3d9a7da61b0e3390bd9fcfcc4c49c8ac57c753a504588fad281e3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhi0EosvCjTOyxIVDs_gjie0LUlUBRSriAmfLcSZdbxN7sZ2i_SH8Xxy2VC3iwMG2ZuaZGc_oReglJRtKuHzb7eyGEdpuuKKP0Io2nFVUMvEYrQghoiKKkRP0LKVdMRWR4ik6YUIJ2XC-Qj8vXMohHnAYsN3G4J3Fzg-jmSbz29-7FGIPMRW3jWASJJy3gKNL10vSZ4jXMGILY7lMtM6HyZzibs64D4X1IWMbYoTRZMA_XN4-SNmH8VASblyclw4D2OyCf46eDGZM8OL2XaNvH95_Pb-oLr98_HR-dlnZWvJcWcOMrNsGOtHxXhnRm5Z2BDhXpOvVYAdra1srK41thBUNNw2pGykH0zNJga_Ru2Pd_dxN0FvwOZpR76ObTDzoYJx-GPFuq6_CjW5YzVXZ4Bq9uS0Qw_cZUtaTS8tgxkOYk6aylZy0jKj_QBvWlkN5QV__he7CHH3ZxEKpuma8bQt1eqRsDClFGO7-TYlepKGLNPQiDV2kUfBX92e9g_9ooQDVEUgl5K8g3uv6r4K_AMvvx8o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859442366</pqid></control><display><type>article</type><title>History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection</title><source>MEDLINE</source><source>Nature</source><source>PubMed Central (Training)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sahi, Helka ; Sihto, Harri ; Artama, Miia ; Koljonen, Virve ; Böhling, Tom ; Pukkala, Eero</creator><creatorcontrib>Sahi, Helka ; Sihto, Harri ; Artama, Miia ; Koljonen, Virve ; Böhling, Tom ; Pukkala, Eero</creatorcontrib><description>Background:
We aimed to assess the connection between chronic inflammatory disorders (CIDs) and Merkel cell carcinoma (MCC).
Methods:
Merkel cell carcinoma cases diagnosed in 1978–2009 were extracted from the Finnish Cancer Registry and controls from the Population Registry. Information on reimbursed CIDs was linked to clinicopathological data including Merkel cell polyomavirus (MCV) status by qPCR and immunohistochemistry for the large T antigen of MCV (LTA), Ki-67 and tumour-infiltrating lymphocytes.
Results:
Chronic inflammatory disorders increased the risk of MCC significantly (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.03–1.88), specifically connective tissue/systemic diseases (OR 1.75, 95% CI 1.09–1.80) and diabetic conditions (OR 1.51, 95% CI 1.03–2.22). Chronic inflammatory disorders associated with larger tumour diameter (
P
=0.02) and higher Ki-67 expression (
P
=0.005). The expression of LTA was seen significantly more often in the absence of CIDs (
P
=0.05).
Conclusions:
Patients with CID are at significantly higher risk for aggressive MCC. Merkel cell polyomavirus positivity is more common in MCC patients unafflicted by CID.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2016.391</identifier><identifier>PMID: 27978533</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/255/2514 ; 692/4028/67/1813 ; 692/420/256/2515 ; 692/499 ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Merkel Cell - epidemiology ; Carcinoma, Merkel Cell - virology ; Case-Control Studies ; Chronic Disease ; Connective tissue ; Diabetes ; DNA, Viral - analysis ; Drug Resistance ; Epidemiology ; Female ; Finland - epidemiology ; Hepatitis ; Humans ; Infections ; Inflammation - complications ; Inflammation - epidemiology ; Inflammatory bowel disease ; Inflammatory diseases ; Lupus ; Male ; Medical research ; Merkel cell polyomavirus - genetics ; Merkel cell polyomavirus - isolation & purification ; Middle Aged ; Molecular Medicine ; Multiple sclerosis ; Myasthenia gravis ; Oncology ; Polyomaviridae ; Polyomavirus Infections - epidemiology ; Polyomavirus Infections - virology ; Psoriasis ; Registries ; Rheumatoid arthritis ; Risk Factors ; Sarcoidosis ; Skin Neoplasms - epidemiology ; Skin Neoplasms - virology ; Tumor Virus Infections - epidemiology ; Tumor Virus Infections - virology ; Tumors</subject><ispartof>British journal of cancer, 2017-01, Vol.116 (2), p.260-264</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 17, 2017</rights><rights>Copyright © 2017 Cancer Research UK 2017 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ca2a8465eb7b3d9a7da61b0e3390bd9fcfcc4c49c8ac57c753a504588fad281e3</citedby><cites>FETCH-LOGICAL-c483t-ca2a8465eb7b3d9a7da61b0e3390bd9fcfcc4c49c8ac57c753a504588fad281e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243985/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243985/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27978533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahi, Helka</creatorcontrib><creatorcontrib>Sihto, Harri</creatorcontrib><creatorcontrib>Artama, Miia</creatorcontrib><creatorcontrib>Koljonen, Virve</creatorcontrib><creatorcontrib>Böhling, Tom</creatorcontrib><creatorcontrib>Pukkala, Eero</creatorcontrib><title>History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
We aimed to assess the connection between chronic inflammatory disorders (CIDs) and Merkel cell carcinoma (MCC).
Methods:
Merkel cell carcinoma cases diagnosed in 1978–2009 were extracted from the Finnish Cancer Registry and controls from the Population Registry. Information on reimbursed CIDs was linked to clinicopathological data including Merkel cell polyomavirus (MCV) status by qPCR and immunohistochemistry for the large T antigen of MCV (LTA), Ki-67 and tumour-infiltrating lymphocytes.
Results:
Chronic inflammatory disorders increased the risk of MCC significantly (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.03–1.88), specifically connective tissue/systemic diseases (OR 1.75, 95% CI 1.09–1.80) and diabetic conditions (OR 1.51, 95% CI 1.03–2.22). Chronic inflammatory disorders associated with larger tumour diameter (
P
=0.02) and higher Ki-67 expression (
P
=0.005). The expression of LTA was seen significantly more often in the absence of CIDs (
P
=0.05).
Conclusions:
Patients with CID are at significantly higher risk for aggressive MCC. Merkel cell polyomavirus positivity is more common in MCC patients unafflicted by CID.</description><subject>631/250/255/2514</subject><subject>692/4028/67/1813</subject><subject>692/420/256/2515</subject><subject>692/499</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Merkel Cell - epidemiology</subject><subject>Carcinoma, Merkel Cell - virology</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Connective tissue</subject><subject>Diabetes</subject><subject>DNA, Viral - analysis</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammation - complications</subject><subject>Inflammation - epidemiology</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory diseases</subject><subject>Lupus</subject><subject>Male</subject><subject>Medical research</subject><subject>Merkel cell polyomavirus - genetics</subject><subject>Merkel cell polyomavirus - isolation & purification</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Multiple sclerosis</subject><subject>Myasthenia gravis</subject><subject>Oncology</subject><subject>Polyomaviridae</subject><subject>Polyomavirus Infections - epidemiology</subject><subject>Polyomavirus Infections - virology</subject><subject>Psoriasis</subject><subject>Registries</subject><subject>Rheumatoid arthritis</subject><subject>Risk Factors</subject><subject>Sarcoidosis</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - virology</subject><subject>Tumor Virus Infections - epidemiology</subject><subject>Tumor Virus Infections - virology</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1v1DAQhi0EosvCjTOyxIVDs_gjie0LUlUBRSriAmfLcSZdbxN7sZ2i_SH8Xxy2VC3iwMG2ZuaZGc_oReglJRtKuHzb7eyGEdpuuKKP0Io2nFVUMvEYrQghoiKKkRP0LKVdMRWR4ik6YUIJ2XC-Qj8vXMohHnAYsN3G4J3Fzg-jmSbz29-7FGIPMRW3jWASJJy3gKNL10vSZ4jXMGILY7lMtM6HyZzibs64D4X1IWMbYoTRZMA_XN4-SNmH8VASblyclw4D2OyCf46eDGZM8OL2XaNvH95_Pb-oLr98_HR-dlnZWvJcWcOMrNsGOtHxXhnRm5Z2BDhXpOvVYAdra1srK41thBUNNw2pGykH0zNJga_Ru2Pd_dxN0FvwOZpR76ObTDzoYJx-GPFuq6_CjW5YzVXZ4Bq9uS0Qw_cZUtaTS8tgxkOYk6aylZy0jKj_QBvWlkN5QV__he7CHH3ZxEKpuma8bQt1eqRsDClFGO7-TYlepKGLNPQiDV2kUfBX92e9g_9ooQDVEUgl5K8g3uv6r4K_AMvvx8o</recordid><startdate>20170117</startdate><enddate>20170117</enddate><creator>Sahi, Helka</creator><creator>Sihto, Harri</creator><creator>Artama, Miia</creator><creator>Koljonen, Virve</creator><creator>Böhling, Tom</creator><creator>Pukkala, Eero</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170117</creationdate><title>History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection</title><author>Sahi, Helka ; Sihto, Harri ; Artama, Miia ; Koljonen, Virve ; Böhling, Tom ; Pukkala, Eero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ca2a8465eb7b3d9a7da61b0e3390bd9fcfcc4c49c8ac57c753a504588fad281e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/250/255/2514</topic><topic>692/4028/67/1813</topic><topic>692/420/256/2515</topic><topic>692/499</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Merkel Cell - epidemiology</topic><topic>Carcinoma, Merkel Cell - virology</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Connective tissue</topic><topic>Diabetes</topic><topic>DNA, Viral - analysis</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammation - complications</topic><topic>Inflammation - epidemiology</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory diseases</topic><topic>Lupus</topic><topic>Male</topic><topic>Medical research</topic><topic>Merkel cell polyomavirus - genetics</topic><topic>Merkel cell polyomavirus - isolation & purification</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Multiple sclerosis</topic><topic>Myasthenia gravis</topic><topic>Oncology</topic><topic>Polyomaviridae</topic><topic>Polyomavirus Infections - epidemiology</topic><topic>Polyomavirus Infections - virology</topic><topic>Psoriasis</topic><topic>Registries</topic><topic>Rheumatoid arthritis</topic><topic>Risk Factors</topic><topic>Sarcoidosis</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - virology</topic><topic>Tumor Virus Infections - epidemiology</topic><topic>Tumor Virus Infections - virology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahi, Helka</creatorcontrib><creatorcontrib>Sihto, Harri</creatorcontrib><creatorcontrib>Artama, Miia</creatorcontrib><creatorcontrib>Koljonen, Virve</creatorcontrib><creatorcontrib>Böhling, Tom</creatorcontrib><creatorcontrib>Pukkala, Eero</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahi, Helka</au><au>Sihto, Harri</au><au>Artama, Miia</au><au>Koljonen, Virve</au><au>Böhling, Tom</au><au>Pukkala, Eero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2017-01-17</date><risdate>2017</risdate><volume>116</volume><issue>2</issue><spage>260</spage><epage>264</epage><pages>260-264</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
We aimed to assess the connection between chronic inflammatory disorders (CIDs) and Merkel cell carcinoma (MCC).
Methods:
Merkel cell carcinoma cases diagnosed in 1978–2009 were extracted from the Finnish Cancer Registry and controls from the Population Registry. Information on reimbursed CIDs was linked to clinicopathological data including Merkel cell polyomavirus (MCV) status by qPCR and immunohistochemistry for the large T antigen of MCV (LTA), Ki-67 and tumour-infiltrating lymphocytes.
Results:
Chronic inflammatory disorders increased the risk of MCC significantly (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.03–1.88), specifically connective tissue/systemic diseases (OR 1.75, 95% CI 1.09–1.80) and diabetic conditions (OR 1.51, 95% CI 1.03–2.22). Chronic inflammatory disorders associated with larger tumour diameter (
P
=0.02) and higher Ki-67 expression (
P
=0.005). The expression of LTA was seen significantly more often in the absence of CIDs (
P
=0.05).
Conclusions:
Patients with CID are at significantly higher risk for aggressive MCC. Merkel cell polyomavirus positivity is more common in MCC patients unafflicted by CID.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27978533</pmid><doi>10.1038/bjc.2016.391</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2017-01, Vol.116 (2), p.260-264 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5243985 |
| source | MEDLINE; Nature; PubMed Central (Training); EZB-FREE-00999 freely available EZB journals |
| subjects | 631/250/255/2514 692/4028/67/1813 692/420/256/2515 692/499 Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Merkel Cell - epidemiology Carcinoma, Merkel Cell - virology Case-Control Studies Chronic Disease Connective tissue Diabetes DNA, Viral - analysis Drug Resistance Epidemiology Female Finland - epidemiology Hepatitis Humans Infections Inflammation - complications Inflammation - epidemiology Inflammatory bowel disease Inflammatory diseases Lupus Male Medical research Merkel cell polyomavirus - genetics Merkel cell polyomavirus - isolation & purification Middle Aged Molecular Medicine Multiple sclerosis Myasthenia gravis Oncology Polyomaviridae Polyomavirus Infections - epidemiology Polyomavirus Infections - virology Psoriasis Registries Rheumatoid arthritis Risk Factors Sarcoidosis Skin Neoplasms - epidemiology Skin Neoplasms - virology Tumor Virus Infections - epidemiology Tumor Virus Infections - virology Tumors |
| title | History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T01%3A58%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=History%20of%20chronic%20inflammatory%20disorders%20increases%20the%20risk%20of%20Merkel%20cell%20carcinoma,%20but%20does%20not%20correlate%20with%20Merkel%20cell%20polyomavirus%20infection&rft.jtitle=British%20journal%20of%20cancer&rft.au=Sahi,%20Helka&rft.date=2017-01-17&rft.volume=116&rft.issue=2&rft.spage=260&rft.epage=264&rft.pages=260-264&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/bjc.2016.391&rft_dat=%3Cproquest_pubme%3E4303589661%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859442366&rft_id=info:pmid/27978533&rfr_iscdi=true |