RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice

Receptor for Advanced Glycation Endproducts (RAGE), a multiligand receptor in the immunoglobulin superfamily, functions as a signal‐transducing cell surface acceptor for amyloid‐beta peptide (Aβ). In view of increased neuronal expression of RAGE in Alzheimer's disease, a murine model was develo...

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Veröffentlicht in:	The EMBO journal 2004-10, Vol.23 (20), p.4096-4105
Hauptverfasser:	Arancio, Ottavio, Zhang, Hui Ping, Chen, Xi, Lin, Chang, Trinchese, Fabrizio, Puzzo, Daniela, Liu, Shumin, Hegde, Ashok, Yan, Shi Fang, Stern, Alan, Luddy, John S, Lue, Lih-Fen, Walker, Douglas G, Roher, Alex, Buttini, Manuel, Mucke, Lennart, Li, Weiying, Schmidt, Ann Marie, Kindy, Mark, Hyslop, Paul A, Stern, David M, Du Yan, Shirley Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	EMBO27 neuroinflammation neuronal degeneration NF-κB activation synaptic plasticity
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