High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress....

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.40620-40620, Article 40620
Hauptverfasser:	Aston, Daniel, Capel, Rebecca A., Ford, Kerrie L., Christian, Helen C., Mirams, Gary R., Rog-Zielinska, Eva A., Kohl, Peter, Galione, Antony, Burton, Rebecca A. B., Terrar, Derek A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/535/1258 692/4019/592 Adenine Animals Biomarkers Calcium Calcium - metabolism Calcium Channels - metabolism Calcium phosphates Calcium Signaling Calcium signalling Cardiac muscle Cardiomyocytes Cell death Electron microscopy Fourier analysis Heart Heart diseases Heart Ventricles - cytology Heart Ventricles - metabolism Humanities and Social Sciences Hypotheses Kinases Lysosomal-Associated Membrane Protein 2 - metabolism Lysosomes Lysosomes - metabolism Lysosomes - ultrastructure Male Membranes Microscopy Mitochondria multidisciplinary Myocytes Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure NAADP NADP - analogs & derivatives NADP - metabolism Nicotinic acid Organelles Organelles - metabolism Pharmacology Phosphorylation Physiology Proteins Pulmonary arteries Rabbits Reperfusion Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Science Science (multidisciplinary) Ventricle
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