Engineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis

Milbemycins, produced from Streptomyces hygroscopicus subsp. aureolacrimosus and Streptomyces bingchenggensis, are 16-membered macrolides that share structural similarity with avermectin produced from Streptomyces avermitilis. Milbemycins possess strong acaricidal, insecticidal, and anthelmintic act...

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Veröffentlicht in:	Microbial cell factories 2017-01, Vol.16 (1), p.9, Article 9
Hauptverfasser:	Kim, Myoun-Su, Cho, Wan-Je, Song, Myoung Chong, Park, Seong-Whan, Kim, Kaeun, Kim, Eunji, Lee, Naryeong, Nam, Sang-Jip, Oh, Ki-Hoon, Yoon, Yeo Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Biosynthesis Biosynthetic Pathways - genetics Fermentation Insecticides Ivermectin - analogs & derivatives Ivermectin - metabolism Macrolides Macrolides - isolation & purification Macrolides - metabolism Methyltransferases - metabolism Molecular Structure Physiological aspects Polyketide Synthases - genetics Polyketide Synthases - metabolism Streptomyces - genetics Streptomyces - metabolism Transferases
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