Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice
Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP 1...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2017-01, Vol.7 (1), p.40402-40402, Article 40402 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 40402 |
|---|---|
| container_issue | 1 |
| container_start_page | 40402 |
| container_title | Scientific reports |
| container_volume | 7 |
| creator | Wang, Zhijun Xie, Jianhua Yang, Yujiao Zhang, Fan Wang, Shengnan Wu, Ting Shen, Mingyue Xie, Mingyong |
| description | Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of
Cyclocarya paliurus
polysaccharides (CP). A sulfated CP, S-CP
1–4
was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP
1–4
was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP
1–4
significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP
1–4
could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP
1–4
may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements. |
| doi_str_mv | 10.1038/srep40402 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5240341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861553390</sourcerecordid><originalsourceid>FETCH-LOGICAL-c544t-82ea60f75051b7b96bdb49d131a20398a54b607a5a999e3bf18d51643961fce23</originalsourceid><addsrcrecordid>eNplkc1u1DAUhSMEolXpghdAltgAUsC_SbxBQiP-pEosgHV0Y9_MuDhxsJOKvApPi6dTRlPwxrbu53Pv8SmKp4y-ZlQ0b1LESVJJ-YPinFOpSi44f3hyPisuU7qmeSmuJdOPizPeUC15rc6L318X38OMlmxW44OBuAKZwLslLolMwa8JjNlBdBYTGSD-QOtXAvOM45LfJeLG3sMwwOzCSGC0JPxyNt9ukFgYYIuZIN5N4b5YOUe87TuAiWHa7UGD3qdbjcEZfFI86sEnvLzbL4rvH95_23wqr758_Lx5d1UaJeVcNhyhon2tqGJd3emqs53UlgkGnArdgJJdRWtQoLVG0fWssYpVUuiK9Qa5uCjeHnSnpRvQGhznCL6dost21zaAa-9XRrdrt-GmVVxSIVkWeHEnEMPPBdPcDi7tvcCIYUktayqmlBCaZvT5P-h1WOKY7WVKa8VoVe-plwcq_0zK-fbHYRht96G3x9Az--x0-iP5N-IMvDoAKZfGLcaTlv-p_QHQnrp-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899510670</pqid></control><display><type>article</type><title>Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Wang, Zhijun ; Xie, Jianhua ; Yang, Yujiao ; Zhang, Fan ; Wang, Shengnan ; Wu, Ting ; Shen, Mingyue ; Xie, Mingyong</creator><creatorcontrib>Wang, Zhijun ; Xie, Jianhua ; Yang, Yujiao ; Zhang, Fan ; Wang, Shengnan ; Wu, Ting ; Shen, Mingyue ; Xie, Mingyong</creatorcontrib><description>Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of
Cyclocarya paliurus
polysaccharides (CP). A sulfated CP, S-CP
1–4
was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP
1–4
was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP
1–4
significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP
1–4
could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP
1–4
may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep40402</identifier><identifier>PMID: 28094275</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/256/2516 ; 64/60 ; 692/699/249/2510/2511 ; Animals ; Anti-inflammatory agents ; Antioxidants - metabolism ; Cell Survival - drug effects ; Cytokines - metabolism ; Dietary supplements ; Humanities and Social Sciences ; IL-1β ; Immunology ; Inflammation ; Inflammation - drug therapy ; Inflammation - pathology ; Juglandaceae - chemistry ; Lipopolysaccharides ; Liver - drug effects ; Liver - physiopathology ; Macrophages ; Macrophages - drug effects ; Macrophages - metabolism ; Macrophages - pathology ; Malondialdehyde - metabolism ; Mice ; Models, Biological ; Molecular Weight ; multidisciplinary ; Nitric oxide ; Nitric Oxide - metabolism ; Oxidative Stress - drug effects ; Phagocytosis - drug effects ; Polysaccharides - chemistry ; Polysaccharides - pharmacology ; Polysaccharides - therapeutic use ; RAW 264.7 Cells ; Rodents ; Saccharides ; Science ; Science (multidisciplinary) ; Spectroscopy, Fourier Transform Infrared ; Sulfates - chemistry ; Sulfates - pharmacology ; Sulfates - therapeutic use ; Superoxide Dismutase - metabolism ; Viscera - drug effects ; Viscera - pathology</subject><ispartof>Scientific reports, 2017-01, Vol.7 (1), p.40402-40402, Article 40402</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-82ea60f75051b7b96bdb49d131a20398a54b607a5a999e3bf18d51643961fce23</citedby><cites>FETCH-LOGICAL-c544t-82ea60f75051b7b96bdb49d131a20398a54b607a5a999e3bf18d51643961fce23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28094275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhijun</creatorcontrib><creatorcontrib>Xie, Jianhua</creatorcontrib><creatorcontrib>Yang, Yujiao</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Wang, Shengnan</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Shen, Mingyue</creatorcontrib><creatorcontrib>Xie, Mingyong</creatorcontrib><title>Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of
Cyclocarya paliurus
polysaccharides (CP). A sulfated CP, S-CP
1–4
was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP
1–4
was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP
1–4
significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP
1–4
could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP
1–4
may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.</description><subject>631/250/256/2516</subject><subject>64/60</subject><subject>692/699/249/2510/2511</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Cytokines - metabolism</subject><subject>Dietary supplements</subject><subject>Humanities and Social Sciences</subject><subject>IL-1β</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - pathology</subject><subject>Juglandaceae - chemistry</subject><subject>Lipopolysaccharides</subject><subject>Liver - drug effects</subject><subject>Liver - physiopathology</subject><subject>Macrophages</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Molecular Weight</subject><subject>multidisciplinary</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Phagocytosis - drug effects</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - therapeutic use</subject><subject>RAW 264.7 Cells</subject><subject>Rodents</subject><subject>Saccharides</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Sulfates - chemistry</subject><subject>Sulfates - pharmacology</subject><subject>Sulfates - therapeutic use</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Viscera - drug effects</subject><subject>Viscera - pathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc1u1DAUhSMEolXpghdAltgAUsC_SbxBQiP-pEosgHV0Y9_MuDhxsJOKvApPi6dTRlPwxrbu53Pv8SmKp4y-ZlQ0b1LESVJJ-YPinFOpSi44f3hyPisuU7qmeSmuJdOPizPeUC15rc6L318X38OMlmxW44OBuAKZwLslLolMwa8JjNlBdBYTGSD-QOtXAvOM45LfJeLG3sMwwOzCSGC0JPxyNt9ukFgYYIuZIN5N4b5YOUe87TuAiWHa7UGD3qdbjcEZfFI86sEnvLzbL4rvH95_23wqr758_Lx5d1UaJeVcNhyhon2tqGJd3emqs53UlgkGnArdgJJdRWtQoLVG0fWssYpVUuiK9Qa5uCjeHnSnpRvQGhznCL6dost21zaAa-9XRrdrt-GmVVxSIVkWeHEnEMPPBdPcDi7tvcCIYUktayqmlBCaZvT5P-h1WOKY7WVKa8VoVe-plwcq_0zK-fbHYRht96G3x9Az--x0-iP5N-IMvDoAKZfGLcaTlv-p_QHQnrp-</recordid><startdate>20170117</startdate><enddate>20170117</enddate><creator>Wang, Zhijun</creator><creator>Xie, Jianhua</creator><creator>Yang, Yujiao</creator><creator>Zhang, Fan</creator><creator>Wang, Shengnan</creator><creator>Wu, Ting</creator><creator>Shen, Mingyue</creator><creator>Xie, Mingyong</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170117</creationdate><title>Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice</title><author>Wang, Zhijun ; Xie, Jianhua ; Yang, Yujiao ; Zhang, Fan ; Wang, Shengnan ; Wu, Ting ; Shen, Mingyue ; Xie, Mingyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-82ea60f75051b7b96bdb49d131a20398a54b607a5a999e3bf18d51643961fce23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/250/256/2516</topic><topic>64/60</topic><topic>692/699/249/2510/2511</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Antioxidants - metabolism</topic><topic>Cell Survival - drug effects</topic><topic>Cytokines - metabolism</topic><topic>Dietary supplements</topic><topic>Humanities and Social Sciences</topic><topic>IL-1β</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - pathology</topic><topic>Juglandaceae - chemistry</topic><topic>Lipopolysaccharides</topic><topic>Liver - drug effects</topic><topic>Liver - physiopathology</topic><topic>Macrophages</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - pathology</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Molecular Weight</topic><topic>multidisciplinary</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Phagocytosis - drug effects</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - therapeutic use</topic><topic>RAW 264.7 Cells</topic><topic>Rodents</topic><topic>Saccharides</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Sulfates - chemistry</topic><topic>Sulfates - pharmacology</topic><topic>Sulfates - therapeutic use</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Viscera - drug effects</topic><topic>Viscera - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhijun</creatorcontrib><creatorcontrib>Xie, Jianhua</creatorcontrib><creatorcontrib>Yang, Yujiao</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Wang, Shengnan</creatorcontrib><creatorcontrib>Wu, Ting</creatorcontrib><creatorcontrib>Shen, Mingyue</creatorcontrib><creatorcontrib>Xie, Mingyong</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhijun</au><au>Xie, Jianhua</au><au>Yang, Yujiao</au><au>Zhang, Fan</au><au>Wang, Shengnan</au><au>Wu, Ting</au><au>Shen, Mingyue</au><au>Xie, Mingyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-01-17</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>40402</spage><epage>40402</epage><pages>40402-40402</pages><artnum>40402</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of
Cyclocarya paliurus
polysaccharides (CP). A sulfated CP, S-CP
1–4
was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP
1–4
was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP
1–4
significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP
1–4
could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP
1–4
may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28094275</pmid><doi>10.1038/srep40402</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2017-01, Vol.7 (1), p.40402-40402, Article 40402 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5240341 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Free; PubMed Central; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 631/250/256/2516 64/60 692/699/249/2510/2511 Animals Anti-inflammatory agents Antioxidants - metabolism Cell Survival - drug effects Cytokines - metabolism Dietary supplements Humanities and Social Sciences IL-1β Immunology Inflammation Inflammation - drug therapy Inflammation - pathology Juglandaceae - chemistry Lipopolysaccharides Liver - drug effects Liver - physiopathology Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Malondialdehyde - metabolism Mice Models, Biological Molecular Weight multidisciplinary Nitric oxide Nitric Oxide - metabolism Oxidative Stress - drug effects Phagocytosis - drug effects Polysaccharides - chemistry Polysaccharides - pharmacology Polysaccharides - therapeutic use RAW 264.7 Cells Rodents Saccharides Science Science (multidisciplinary) Spectroscopy, Fourier Transform Infrared Sulfates - chemistry Sulfates - pharmacology Sulfates - therapeutic use Superoxide Dismutase - metabolism Viscera - drug effects Viscera - pathology |
| title | Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A56%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sulfated%20Cyclocarya%20paliurus%20polysaccharides%20markedly%20attenuates%20inflammation%20and%20oxidative%20damage%20in%20lipopolysaccharide-treated%20macrophage%20cells%20and%20mice&rft.jtitle=Scientific%20reports&rft.au=Wang,%20Zhijun&rft.date=2017-01-17&rft.volume=7&rft.issue=1&rft.spage=40402&rft.epage=40402&rft.pages=40402-40402&rft.artnum=40402&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep40402&rft_dat=%3Cproquest_pubme%3E1861553390%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899510670&rft_id=info:pmid/28094275&rfr_iscdi=true |