Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

Opioid tolerance and the potential for addiction is a significant burden associated with pain management, yet its precise underlying mechanism and prevention remain elusive. Immune signaling contributes to the decreased efficacy of opioids, and we recently demonstrated that Toll-like receptor 4 (TLR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2017-02, Vol.42 (3), p.661-670
Hauptverfasser:	Eidson, Lori N, Inoue, Kiyoshi, Young, Larry J, Tansey, Malu G, Murphy, Anne Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Animals Chronic pain Cytokines Drug Tolerance - physiology Glutamic Acid - metabolism Homeostasis Hypotheses Inflammation - chemically induced Inflammation - drug therapy Inflammation - immunology Male Morphine Morphine - pharmacology Narcotics Narcotics - pharmacology Neurosciences Original Pain management Peptides Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!