Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target

Von Hippel-Lindau (VHL)-associated hemangioblastomas (VHL-HB) arise in the central nervous system (CNS), and are a leading cause of morbidity and mortality in VHL disease. Currently, surgical resection is the most effective way to manage symptomatic VHL-HBs. Surgically unresectable VHL-HBs or those...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.40822-40822, Article 40822
Hauptverfasser:	Sizdahkhani, Saman, Feldman, Michael J., Piazza, Martin G., Ksendzovsky, Alexander, Edwards, Nancy A., Ray-Chaudhury, Abhik, Maric, Dragan, Merrill, Marsha J., Pacak, Karel, Zhuang, Zhengping, Chittiboina, Prashant
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/2 13/31 13/51 14 38 38/77 59 59/78 692/4028/546 692/4028/67/1244 692/699/375/1922 Apoptosis Apoptosis - drug effects Avidity Brain Neoplasms - drug therapy Brain Neoplasms - pathology Caspase Caspase-3 Cells, Cultured Central nervous system Female Hemangioblastoma - drug therapy Hemangioblastoma - pathology Humanities and Social Sciences Humans Infarction Middle Aged Morbidity multidisciplinary Neoplasia Nervous system Neurological disorders Octreotide Octreotide - analogs & derivatives Octreotide - pharmacology Octreotide - therapeutic use Organometallic Compounds - therapeutic use Patients Positron emission tomography Radiopharmaceuticals - therapeutic use Receptors, Somatostatin - agonists Receptors, Somatostatin - genetics Receptors, Somatostatin - metabolism Science Science (multidisciplinary) Somatostatin Somatostatin receptors Stromal cells Tumors Vascular endothelial growth factor VHL protein von Hippel-Lindau Disease - drug therapy von Hippel-Lindau Disease - pathology
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