Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D
Mycoses induced by C.albicans or A.fumigatus can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as t...
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| Veröffentlicht in: | Scientific reports 2017-01, Vol.7 (1), p.40598-40598, Article 40598 |
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| creator | Riege, Konstantin Hölzer, Martin Klassert, Tilman E. Barth, Emanuel Bräuer, Julia Collatz, Maximilian Hufsky, Franziska Mostajo, Nelly Stock, Magdalena Vogel, Bertram Slevogt, Hortense Marz, Manja |
| description | Mycoses induced by
C.albicans
or
A.fumigatus
can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown. We show that in monocytes both vitamins regulate ncRNAs involved in amino acid metabolism and immune system processes using comprehensive RNA-Seq analyses. Compared to protein-coding genes, fungi and bacteria induced an expression change in relatively few ncRNAs, but with massive fold changes of up to 4000. We defined the landscape of long-ncRNAs (lncRNAs) in response to pathogens and observed variation in the isoforms composition for several lncRNA following infection and vitamin treatment. Most of the involved antisense RNAs are regulated and positively correlated with their sense protein-coding genes. We investigated lncRNAs with stimulus specific immunomodulatory activity as potential marker genes: LINC00595, SBF2-AS1 (
A.fumigatus
) and RP11-588G21.2, RP11-394l13.1 (
C.albicans
) might be detectable in the early phase of infection and serve as therapeutic targets in the future. |
| doi_str_mv | 10.1038/srep40598 |
| format | Article |
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C.albicans
or
A.fumigatus
can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown. We show that in monocytes both vitamins regulate ncRNAs involved in amino acid metabolism and immune system processes using comprehensive RNA-Seq analyses. Compared to protein-coding genes, fungi and bacteria induced an expression change in relatively few ncRNAs, but with massive fold changes of up to 4000. We defined the landscape of long-ncRNAs (lncRNAs) in response to pathogens and observed variation in the isoforms composition for several lncRNA following infection and vitamin treatment. Most of the involved antisense RNAs are regulated and positively correlated with their sense protein-coding genes. We investigated lncRNAs with stimulus specific immunomodulatory activity as potential marker genes: LINC00595, SBF2-AS1 (
A.fumigatus
) and RP11-588G21.2, RP11-394l13.1 (
C.albicans
) might be detectable in the early phase of infection and serve as therapeutic targets in the future.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep40598</identifier><identifier>PMID: 28094339</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 38/91 ; 631/114/2114 ; 631/114/2163 ; 692/699/255/1672 ; Amino acids ; Antisense RNA ; Bacterial diseases ; Bacterial infections ; Bacterial Infections - genetics ; Bacterial Infections - microbiology ; Fungi ; Gene Expression Regulation - drug effects ; Gene regulation ; Humanities and Social Sciences ; Humans ; Immune response ; Immune system ; Immunomodulation ; Isoforms ; Monocytes ; Monocytes - metabolism ; multidisciplinary ; Mycoses - genetics ; Mycoses - microbiology ; Ribonucleic acid ; RNA ; RNA, Antisense - genetics ; RNA, Long Noncoding - chemistry ; RNA, Long Noncoding - genetics ; RNA, Messenger - genetics ; RNA, Untranslated - genetics ; Science ; Transcription factors ; Vitamin A - metabolism ; Vitamin A - pharmacology ; Vitamin D ; Vitamin D - metabolism ; Vitamin D - pharmacology ; Vitamins</subject><ispartof>Scientific reports, 2017-01, Vol.7 (1), p.40598-40598, Article 40598</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-1d0699c0885ba1c516c6e84f76a48db80a7123a86b206d337f461daf7eb382583</citedby><cites>FETCH-LOGICAL-c438t-1d0699c0885ba1c516c6e84f76a48db80a7123a86b206d337f461daf7eb382583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240112/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240112/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28094339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riege, Konstantin</creatorcontrib><creatorcontrib>Hölzer, Martin</creatorcontrib><creatorcontrib>Klassert, Tilman E.</creatorcontrib><creatorcontrib>Barth, Emanuel</creatorcontrib><creatorcontrib>Bräuer, Julia</creatorcontrib><creatorcontrib>Collatz, Maximilian</creatorcontrib><creatorcontrib>Hufsky, Franziska</creatorcontrib><creatorcontrib>Mostajo, Nelly</creatorcontrib><creatorcontrib>Stock, Magdalena</creatorcontrib><creatorcontrib>Vogel, Bertram</creatorcontrib><creatorcontrib>Slevogt, Hortense</creatorcontrib><creatorcontrib>Marz, Manja</creatorcontrib><title>Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Mycoses induced by
C.albicans
or
A.fumigatus
can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown. We show that in monocytes both vitamins regulate ncRNAs involved in amino acid metabolism and immune system processes using comprehensive RNA-Seq analyses. Compared to protein-coding genes, fungi and bacteria induced an expression change in relatively few ncRNAs, but with massive fold changes of up to 4000. We defined the landscape of long-ncRNAs (lncRNAs) in response to pathogens and observed variation in the isoforms composition for several lncRNA following infection and vitamin treatment. Most of the involved antisense RNAs are regulated and positively correlated with their sense protein-coding genes. We investigated lncRNAs with stimulus specific immunomodulatory activity as potential marker genes: LINC00595, SBF2-AS1 (
A.fumigatus
) and RP11-588G21.2, RP11-394l13.1 (
C.albicans
) might be detectable in the early phase of infection and serve as therapeutic targets in the future.</description><subject>38/39</subject><subject>38/91</subject><subject>631/114/2114</subject><subject>631/114/2163</subject><subject>692/699/255/1672</subject><subject>Amino acids</subject><subject>Antisense RNA</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Bacterial Infections - genetics</subject><subject>Bacterial Infections - microbiology</subject><subject>Fungi</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene regulation</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Isoforms</subject><subject>Monocytes</subject><subject>Monocytes - metabolism</subject><subject>multidisciplinary</subject><subject>Mycoses - genetics</subject><subject>Mycoses - microbiology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Antisense - 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genetics</topic><topic>Bacterial Infections - microbiology</topic><topic>Fungi</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene regulation</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunomodulation</topic><topic>Isoforms</topic><topic>Monocytes</topic><topic>Monocytes - metabolism</topic><topic>multidisciplinary</topic><topic>Mycoses - genetics</topic><topic>Mycoses - microbiology</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Antisense - genetics</topic><topic>RNA, Long Noncoding - chemistry</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Untranslated - genetics</topic><topic>Science</topic><topic>Transcription factors</topic><topic>Vitamin A - metabolism</topic><topic>Vitamin A - pharmacology</topic><topic>Vitamin D</topic><topic>Vitamin D - metabolism</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riege, Konstantin</creatorcontrib><creatorcontrib>Hölzer, Martin</creatorcontrib><creatorcontrib>Klassert, Tilman E.</creatorcontrib><creatorcontrib>Barth, Emanuel</creatorcontrib><creatorcontrib>Bräuer, Julia</creatorcontrib><creatorcontrib>Collatz, Maximilian</creatorcontrib><creatorcontrib>Hufsky, Franziska</creatorcontrib><creatorcontrib>Mostajo, Nelly</creatorcontrib><creatorcontrib>Stock, Magdalena</creatorcontrib><creatorcontrib>Vogel, Bertram</creatorcontrib><creatorcontrib>Slevogt, Hortense</creatorcontrib><creatorcontrib>Marz, Manja</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riege, Konstantin</au><au>Hölzer, Martin</au><au>Klassert, Tilman E.</au><au>Barth, Emanuel</au><au>Bräuer, Julia</au><au>Collatz, Maximilian</au><au>Hufsky, Franziska</au><au>Mostajo, Nelly</au><au>Stock, Magdalena</au><au>Vogel, Bertram</au><au>Slevogt, Hortense</au><au>Marz, Manja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-01-17</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>40598</spage><epage>40598</epage><pages>40598-40598</pages><artnum>40598</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Mycoses induced by
C.albicans
or
A.fumigatus
can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown. We show that in monocytes both vitamins regulate ncRNAs involved in amino acid metabolism and immune system processes using comprehensive RNA-Seq analyses. Compared to protein-coding genes, fungi and bacteria induced an expression change in relatively few ncRNAs, but with massive fold changes of up to 4000. We defined the landscape of long-ncRNAs (lncRNAs) in response to pathogens and observed variation in the isoforms composition for several lncRNA following infection and vitamin treatment. Most of the involved antisense RNAs are regulated and positively correlated with their sense protein-coding genes. We investigated lncRNAs with stimulus specific immunomodulatory activity as potential marker genes: LINC00595, SBF2-AS1 (
A.fumigatus
) and RP11-588G21.2, RP11-394l13.1 (
C.albicans
) might be detectable in the early phase of infection and serve as therapeutic targets in the future.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28094339</pmid><doi>10.1038/srep40598</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2017-01, Vol.7 (1), p.40598-40598, Article 40598 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 38/39 38/91 631/114/2114 631/114/2163 692/699/255/1672 Amino acids Antisense RNA Bacterial diseases Bacterial infections Bacterial Infections - genetics Bacterial Infections - microbiology Fungi Gene Expression Regulation - drug effects Gene regulation Humanities and Social Sciences Humans Immune response Immune system Immunomodulation Isoforms Monocytes Monocytes - metabolism multidisciplinary Mycoses - genetics Mycoses - microbiology Ribonucleic acid RNA RNA, Antisense - genetics RNA, Long Noncoding - chemistry RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Untranslated - genetics Science Transcription factors Vitamin A - metabolism Vitamin A - pharmacology Vitamin D Vitamin D - metabolism Vitamin D - pharmacology Vitamins |
| title | Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D |
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