Activation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys

In our previous study, reactive 4-hydroxy-2-nonenal (4-HNE) was shown to activate Src (a non-receptor tyrosine kinase) by forming an adduct on binding with a specific residue of Src, leading to the activation of proinflammatory signaling pathways in cultured cells. However, to date, the deleterious...

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Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (32), p.50864-50874
Hauptverfasser:	Jang, Eun Ji, Kim, Dae Hyun, Lee, Bonggi, Lee, Eun Kyeong, Chung, Ki Wung, Moon, Kyoung Mi, Kim, Min Jo, An, Hye Jin, Jeong, Ji Won, Kim, Ye Ra, Yu, Byung Pal, Chung, Hae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Aldehydes - metabolism Animals Cellular Senescence - physiology Humans Inflammation - metabolism Kidney - metabolism Kidney - pathology Male Rats Rats, Sprague-Dawley Research Paper: Gerotarget (Focus on Aging) Signal Transduction - physiology src-Family Kinases - metabolism
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