Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

Besides degrading aberrant mRNAs that harbor a premature translation termination codon (PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly "normal" mRNAs that encode for full-length proteins. To identify a bona fide set of such endogenous NMD targets in human cells, we ap...

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Veröffentlicht in:	RNA (Cambridge) 2017-02, Vol.23 (2), p.189-201
Hauptverfasser:	Colombo, Martino, Karousis, Evangelos D, Bourquin, Joël, Bruggmann, Rémy, Mühlemann, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Composition Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism Codon, Nonsense Gene Expression HeLa Cells Humans Introns MicroRNAs - chemistry MicroRNAs - metabolism Nonsense Mediated mRNA Decay Protein Binding RNA Helicases RNA, Long Noncoding - chemistry RNA, Long Noncoding - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA, Small Nucleolar - chemistry RNA, Small Nucleolar - metabolism Telomerase - antagonists & inhibitors Telomerase - genetics Telomerase - metabolism Trans-Activators - antagonists & inhibitors Trans-Activators - genetics Trans-Activators - metabolism Transcriptome
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