Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma
The thymus is known to atrophy during infections; however, a systematic study of changes in thymocyte subpopulations has not been performed. This aspect was investigated, using multi-color flow cytometry, during oral infection of mice with Salmonella Typhimurium ( S . Typhimurium). The major highlig...
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| creator | Majumdar, Shamik Deobagkar-Lele, Mukta Adiga, Vasista Raghavan, Abinaya Wadhwa, Nitin Ahmed, Syed Moiz Rananaware, Supriya Rajendra Chakraborty, Subhashish Joy, Omana Nandi, Dipankar |
| description | The thymus is known to atrophy during infections; however, a systematic study of changes in thymocyte subpopulations has not been performed. This aspect was investigated, using multi-color flow cytometry, during oral infection of mice with
Salmonella
Typhimurium (
S
. Typhimurium). The major highlights are: First, a block in the developmental pathway of CD4
−
CD8
−
double negative (DN) thymocytes is observed. Second, CD4
+
CD8
+
double positive (DP) thymocytes, mainly in the DP1 (CD5
lo
CD3
lo
) and DP2 (CD5
hi
CD3
int
), but not DP3 (CD5
int
CD3
hi
), subsets are reduced. Third, single positive (SP) thymocytes are more resistant to depletion but their maturation is delayed, leading to accumulation of CD24
hi
CD3
hi
SP. Kinetic studies during infection demonstrated differences in sensitivity of thymic subpopulations: Immature single positive (ISP) > DP1, DP2 > DN3, DN4 > DN2 > CD4
+
> CD8
+
. Upon infection, glucocorticoids (GC), inflammatory cytokines, e.g. Ifnγ, etc are induced, which enhance thymocyte death. Treatment with RU486, the GC receptor antagonist, increases the survival of most thymic subsets during infection. Studies with
Ifnγ
−/−
mice demonstrated that endogenous Ifnγ produced during infection enhances the depletion of DN2-DN4 subsets, promotes the accumulation of DP3 and delays the maturation of SP thymocytes. The implications of these observations on host cellular responses during infections are discussed. |
| doi_str_mv | 10.1038/srep40793 |
| format | Article |
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Salmonella
Typhimurium (
S
. Typhimurium). The major highlights are: First, a block in the developmental pathway of CD4
−
CD8
−
double negative (DN) thymocytes is observed. Second, CD4
+
CD8
+
double positive (DP) thymocytes, mainly in the DP1 (CD5
lo
CD3
lo
) and DP2 (CD5
hi
CD3
int
), but not DP3 (CD5
int
CD3
hi
), subsets are reduced. Third, single positive (SP) thymocytes are more resistant to depletion but their maturation is delayed, leading to accumulation of CD24
hi
CD3
hi
SP. Kinetic studies during infection demonstrated differences in sensitivity of thymic subpopulations: Immature single positive (ISP) > DP1, DP2 > DN3, DN4 > DN2 > CD4
+
> CD8
+
. Upon infection, glucocorticoids (GC), inflammatory cytokines, e.g. Ifnγ, etc are induced, which enhance thymocyte death. Treatment with RU486, the GC receptor antagonist, increases the survival of most thymic subsets during infection. Studies with
Ifnγ
−/−
mice demonstrated that endogenous Ifnγ produced during infection enhances the depletion of DN2-DN4 subsets, promotes the accumulation of DP3 and delays the maturation of SP thymocytes. The implications of these observations on host cellular responses during infections are discussed.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep40793</identifier><identifier>PMID: 28091621</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/31 ; 631/250/255/1318 ; 631/80/82/23 ; 64 ; 64/60 ; Animals ; Atrophy ; Biomarkers ; CD4 antigen ; CD8 antigen ; Cell Differentiation - immunology ; Color ; Disease Susceptibility ; Flow cytometry ; Glucocorticoids ; Glucocorticoids - metabolism ; Humanities and Social Sciences ; Immunophenotyping ; Infections ; Inflammation ; Interferon-gamma - metabolism ; Lymphocyte Count ; Maturation ; Mice ; multidisciplinary ; Oral infection ; Rodents ; Salmonella ; Salmonella Infections - immunology ; Salmonella Infections - metabolism ; Salmonella Infections - microbiology ; Salmonella Infections - pathology ; Salmonella typhimurium - physiology ; Science ; Science (multidisciplinary) ; Signal Transduction ; Subpopulations ; T-Lymphocyte Subsets - cytology ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Thymocytes ; Thymocytes - cytology ; Thymocytes - immunology ; Thymocytes - metabolism ; Thymus ; Thymus Gland - immunology ; Thymus Gland - metabolism ; Thymus Gland - pathology</subject><ispartof>Scientific reports, 2017-01, Vol.7 (1), p.40793-40793, Article 40793</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-4a5eccc5908b91efb6b1800d820bbe9921166c7b0114443834193ba0332c61c3</citedby><cites>FETCH-LOGICAL-c438t-4a5eccc5908b91efb6b1800d820bbe9921166c7b0114443834193ba0332c61c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238503/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238503/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28091621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Majumdar, Shamik</creatorcontrib><creatorcontrib>Deobagkar-Lele, Mukta</creatorcontrib><creatorcontrib>Adiga, Vasista</creatorcontrib><creatorcontrib>Raghavan, Abinaya</creatorcontrib><creatorcontrib>Wadhwa, Nitin</creatorcontrib><creatorcontrib>Ahmed, Syed Moiz</creatorcontrib><creatorcontrib>Rananaware, Supriya Rajendra</creatorcontrib><creatorcontrib>Chakraborty, Subhashish</creatorcontrib><creatorcontrib>Joy, Omana</creatorcontrib><creatorcontrib>Nandi, Dipankar</creatorcontrib><title>Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The thymus is known to atrophy during infections; however, a systematic study of changes in thymocyte subpopulations has not been performed. This aspect was investigated, using multi-color flow cytometry, during oral infection of mice with
Salmonella
Typhimurium (
S
. Typhimurium). The major highlights are: First, a block in the developmental pathway of CD4
−
CD8
−
double negative (DN) thymocytes is observed. Second, CD4
+
CD8
+
double positive (DP) thymocytes, mainly in the DP1 (CD5
lo
CD3
lo
) and DP2 (CD5
hi
CD3
int
), but not DP3 (CD5
int
CD3
hi
), subsets are reduced. Third, single positive (SP) thymocytes are more resistant to depletion but their maturation is delayed, leading to accumulation of CD24
hi
CD3
hi
SP. Kinetic studies during infection demonstrated differences in sensitivity of thymic subpopulations: Immature single positive (ISP) > DP1, DP2 > DN3, DN4 > DN2 > CD4
+
> CD8
+
. Upon infection, glucocorticoids (GC), inflammatory cytokines, e.g. Ifnγ, etc are induced, which enhance thymocyte death. Treatment with RU486, the GC receptor antagonist, increases the survival of most thymic subsets during infection. Studies with
Ifnγ
−/−
mice demonstrated that endogenous Ifnγ produced during infection enhances the depletion of DN2-DN4 subsets, promotes the accumulation of DP3 and delays the maturation of SP thymocytes. The implications of these observations on host cellular responses during infections are discussed.</description><subject>13/1</subject><subject>13/31</subject><subject>631/250/255/1318</subject><subject>631/80/82/23</subject><subject>64</subject><subject>64/60</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Biomarkers</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cell Differentiation - immunology</subject><subject>Color</subject><subject>Disease Susceptibility</subject><subject>Flow cytometry</subject><subject>Glucocorticoids</subject><subject>Glucocorticoids - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Immunophenotyping</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interferon-gamma - metabolism</subject><subject>Lymphocyte Count</subject><subject>Maturation</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Oral infection</subject><subject>Rodents</subject><subject>Salmonella</subject><subject>Salmonella Infections - immunology</subject><subject>Salmonella Infections - metabolism</subject><subject>Salmonella Infections - microbiology</subject><subject>Salmonella Infections - pathology</subject><subject>Salmonella typhimurium - physiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction</subject><subject>Subpopulations</subject><subject>T-Lymphocyte Subsets - cytology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Thymocytes</subject><subject>Thymocytes - cytology</subject><subject>Thymocytes - immunology</subject><subject>Thymocytes - metabolism</subject><subject>Thymus</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - metabolism</subject><subject>Thymus Gland - pathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc1u1DAUhS0EotXQBS-ALLGBSgH_xGnMAgm1_FSqxILZR7bjZFzFdrAdpLwQz8kdpowG8MaW_d1zr89B6Dklbyjh7duc7FyTK8kfoXNGalExztjjk_MZusj5nsASTNZUPkVnrCWSNoyeo583bhhssqE4NeG8ZGPn4rSbXFmxCj32qixJFRcDjgMuu9VHsxYLqM62ZNwvyYURf1OTj8FOk8Lbdd45D9eLxy4M1uyL38Exu3EHFaBUdhanONm81xynxUQTU3Emuj7_7nobik0wVwzVqLxXz9CTQU3ZXjzsG7T99HF7_aW6-_r59vrDXWVq3paqVsIaY4QkrZbUDrrRtCWkbxnR2krJKG0ac6UJpXUNFRzs4FoRzplpqOEb9P4gOy_a296ALUlN3ZycV2ntonLd3y_B7box_ugE460AmQ169SCQ4vfF5tJ5B5aCLcHGJXe0baigQAtAX_6D3sclBfgdUFIKUrdCAvX6QJkUM0Q9HIehpNvn3x3zB_bF6fRH8k_aAFwegDzvQ7PppOV_ar8AUVG-ww</recordid><startdate>20170116</startdate><enddate>20170116</enddate><creator>Majumdar, Shamik</creator><creator>Deobagkar-Lele, Mukta</creator><creator>Adiga, Vasista</creator><creator>Raghavan, Abinaya</creator><creator>Wadhwa, Nitin</creator><creator>Ahmed, Syed Moiz</creator><creator>Rananaware, Supriya Rajendra</creator><creator>Chakraborty, Subhashish</creator><creator>Joy, Omana</creator><creator>Nandi, Dipankar</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170116</creationdate><title>Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma</title><author>Majumdar, Shamik ; Deobagkar-Lele, Mukta ; Adiga, Vasista ; Raghavan, Abinaya ; Wadhwa, Nitin ; Ahmed, Syed Moiz ; Rananaware, Supriya Rajendra ; Chakraborty, Subhashish ; Joy, Omana ; Nandi, Dipankar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-4a5eccc5908b91efb6b1800d820bbe9921166c7b0114443834193ba0332c61c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>13/1</topic><topic>13/31</topic><topic>631/250/255/1318</topic><topic>631/80/82/23</topic><topic>64</topic><topic>64/60</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Biomarkers</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Cell Differentiation - immunology</topic><topic>Color</topic><topic>Disease Susceptibility</topic><topic>Flow cytometry</topic><topic>Glucocorticoids</topic><topic>Glucocorticoids - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Immunophenotyping</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Interferon-gamma - metabolism</topic><topic>Lymphocyte Count</topic><topic>Maturation</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Oral infection</topic><topic>Rodents</topic><topic>Salmonella</topic><topic>Salmonella Infections - immunology</topic><topic>Salmonella Infections - metabolism</topic><topic>Salmonella Infections - microbiology</topic><topic>Salmonella Infections - pathology</topic><topic>Salmonella typhimurium - physiology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Signal Transduction</topic><topic>Subpopulations</topic><topic>T-Lymphocyte Subsets - cytology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Thymocytes</topic><topic>Thymocytes - cytology</topic><topic>Thymocytes - immunology</topic><topic>Thymocytes - metabolism</topic><topic>Thymus</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - metabolism</topic><topic>Thymus Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Majumdar, Shamik</creatorcontrib><creatorcontrib>Deobagkar-Lele, Mukta</creatorcontrib><creatorcontrib>Adiga, Vasista</creatorcontrib><creatorcontrib>Raghavan, Abinaya</creatorcontrib><creatorcontrib>Wadhwa, Nitin</creatorcontrib><creatorcontrib>Ahmed, Syed Moiz</creatorcontrib><creatorcontrib>Rananaware, Supriya Rajendra</creatorcontrib><creatorcontrib>Chakraborty, Subhashish</creatorcontrib><creatorcontrib>Joy, Omana</creatorcontrib><creatorcontrib>Nandi, Dipankar</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Majumdar, Shamik</au><au>Deobagkar-Lele, Mukta</au><au>Adiga, Vasista</au><au>Raghavan, Abinaya</au><au>Wadhwa, Nitin</au><au>Ahmed, Syed Moiz</au><au>Rananaware, Supriya Rajendra</au><au>Chakraborty, Subhashish</au><au>Joy, Omana</au><au>Nandi, Dipankar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-01-16</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>40793</spage><epage>40793</epage><pages>40793-40793</pages><artnum>40793</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The thymus is known to atrophy during infections; however, a systematic study of changes in thymocyte subpopulations has not been performed. This aspect was investigated, using multi-color flow cytometry, during oral infection of mice with
Salmonella
Typhimurium (
S
. Typhimurium). The major highlights are: First, a block in the developmental pathway of CD4
−
CD8
−
double negative (DN) thymocytes is observed. Second, CD4
+
CD8
+
double positive (DP) thymocytes, mainly in the DP1 (CD5
lo
CD3
lo
) and DP2 (CD5
hi
CD3
int
), but not DP3 (CD5
int
CD3
hi
), subsets are reduced. Third, single positive (SP) thymocytes are more resistant to depletion but their maturation is delayed, leading to accumulation of CD24
hi
CD3
hi
SP. Kinetic studies during infection demonstrated differences in sensitivity of thymic subpopulations: Immature single positive (ISP) > DP1, DP2 > DN3, DN4 > DN2 > CD4
+
> CD8
+
. Upon infection, glucocorticoids (GC), inflammatory cytokines, e.g. Ifnγ, etc are induced, which enhance thymocyte death. Treatment with RU486, the GC receptor antagonist, increases the survival of most thymic subsets during infection. Studies with
Ifnγ
−/−
mice demonstrated that endogenous Ifnγ produced during infection enhances the depletion of DN2-DN4 subsets, promotes the accumulation of DP3 and delays the maturation of SP thymocytes. The implications of these observations on host cellular responses during infections are discussed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28091621</pmid><doi>10.1038/srep40793</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2017-01, Vol.7 (1), p.40793-40793, Article 40793 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5238503 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 13/1 13/31 631/250/255/1318 631/80/82/23 64 64/60 Animals Atrophy Biomarkers CD4 antigen CD8 antigen Cell Differentiation - immunology Color Disease Susceptibility Flow cytometry Glucocorticoids Glucocorticoids - metabolism Humanities and Social Sciences Immunophenotyping Infections Inflammation Interferon-gamma - metabolism Lymphocyte Count Maturation Mice multidisciplinary Oral infection Rodents Salmonella Salmonella Infections - immunology Salmonella Infections - metabolism Salmonella Infections - microbiology Salmonella Infections - pathology Salmonella typhimurium - physiology Science Science (multidisciplinary) Signal Transduction Subpopulations T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymocytes Thymocytes - cytology Thymocytes - immunology Thymocytes - metabolism Thymus Thymus Gland - immunology Thymus Gland - metabolism Thymus Gland - pathology |
| title | Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A54%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20susceptibility%20and%20maturation%20of%20thymocyte%20subsets%20during%20Salmonella%20Typhimurium%20infection:%20insights%20on%20the%20roles%20of%20glucocorticoids%20and%20Interferon-gamma&rft.jtitle=Scientific%20reports&rft.au=Majumdar,%20Shamik&rft.date=2017-01-16&rft.volume=7&rft.issue=1&rft.spage=40793&rft.epage=40793&rft.pages=40793-40793&rft.artnum=40793&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep40793&rft_dat=%3Cproquest_pubme%3E1899504859%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899504859&rft_id=info:pmid/28091621&rfr_iscdi=true |