A Simple Thermoplastic Substrate Containing Hierarchical Silica Lamellae for High-Molecular-Weight DNA Extraction

An inexpensive, magnetic thermoplastic nanomaterial is developed utilizing a hierarchical layering of micro‐ and nanoscale silica lamellae to create a high‐surface‐area and low‐shear substrate capable of capturing vast amounts of ultrahigh‐molecular‐weight DNA. Extraction is performed via a simple 4...

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Veröffentlicht in:	Advanced materials (Weinheim) 2016-12, Vol.28 (48), p.10630-10636
Hauptverfasser:	Zhang, Ye, Zhang, Yi, Burke, Jeffrey M., Gleitsman, Kristin, Friedrich, Sarah M., Liu, Kelvin J., Wang, Tza-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Deoxyribonucleic acid DNA DNA - chemistry DNA - isolation & purification Extraction high molecular weight Humans long read sequencing Magnetics MCF-7 Cells Microparticles Molecular Weight Nanomaterials nanoscale silica Nanostructure Nanostructures - chemistry Silicon dioxide Silicon Dioxide - chemistry Solid Phase Extraction - methods solid-phase extraction Substrates thermoplastic Thermoplastic resins
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Beschreibung
Zusammenfassung:	An inexpensive, magnetic thermoplastic nanomaterial is developed utilizing a hierarchical layering of micro‐ and nanoscale silica lamellae to create a high‐surface‐area and low‐shear substrate capable of capturing vast amounts of ultrahigh‐molecular‐weight DNA. Extraction is performed via a simple 45 min process and is capable of achieving binding capacities up to 1 000 000 times greater than silica microparticles.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201603738