An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

The Sonic hedgehog (Shh) signalling pathway plays important roles during development and in cancer. Here we report a Shh-induced epigenetic switch that cooperates with Gli to control transcription outcomes. Before induction, poised Shh target genes are marked by a bivalent chromatin domain containin...

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Veröffentlicht in:	Nature communications 2014-11, Vol.5 (1), p.5425-5425, Article 5425
Hauptverfasser:	Shi, Xuanming, Zhang, Zilai, Zhan, Xiaoming, Cao, Mou, Satoh, Takashi, Akira, Shizuo, Shpargel, Karl, Magnuson, Terry, Li, Qingtian, Wang, Rongfu, Wang, Chaochen, Ge, Kai, Wu, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	38/15 38/39 38/89 631/136 631/208/2489/2487/2486 631/67/1922 631/80/86 82/51 Animals Cells, Cultured Cerebellum - growth & development Epigenesis, Genetic Female Hedgehog Proteins - metabolism Histone-Lysine N-Methyltransferase - metabolism Humanities and Social Sciences Jumonji Domain-Containing Histone Demethylases - metabolism Kruppel-Like Transcription Factors - metabolism Medulloblastoma - genetics Medulloblastoma - metabolism Mice, Inbred C57BL multidisciplinary Myeloid-Lymphoid Leukemia Protein - metabolism Polycomb Repressive Complex 2 - metabolism Pregnancy Science Science (multidisciplinary) Zinc Finger Protein GLI1
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