Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biomedical optics express 2017-01, Vol.8 (1), p.207-222
Hauptverfasser: Salas, Matthias, Augustin, Marco, Ginner, Laurin, Kumar, Abhishek, Baumann, Bernhard, Leitgeb, Rainer, Drexler, Wolfgang, Prager, Sonja, Hafner, Julia, Schmidt-Erfurth, Ursula, Pircher, Michael
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 222
container_issue 1
container_start_page 207
container_title Biomedical optics express
container_volume 8
creator Salas, Matthias
Augustin, Marco
Ginner, Laurin
Kumar, Abhishek
Baumann, Bernhard
Leitgeb, Rainer
Drexler, Wolfgang
Prager, Sonja
Hafner, Julia
Schmidt-Erfurth, Ursula
Pircher, Michael
description The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.
doi_str_mv 10.1364/BOE.8.000207
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5231293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861576418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-7349445e974cd7c002a2e6be8552c09b5a998f0930d49f42d9f0eab6aae5e5c23</originalsourceid><addsrcrecordid>eNpVkc1P3DAQxa2KqrsCbj1XOfZAtv5M7EslQPRDQuJSuFqzzmTXKImDnSyCv75uF1Zw8pP9mzeeeYR8ZnTFRCW_XdxcrfSKUspp_YEsOVNVWVOtjt7oBTlN6T4zVMqaCv2JLLhmlEnGlyTe-TRD559h8mEoQlv03sVQOhh910H0mIo5-WFThHHyDrrChS1GHBwWU-jDJsK4fSpg2PhX_einbb5o_oswTwU0kGt3uLdIJ-RjC13C05fzmNz-uPpz-au8vvn5-_L8unRCy6mshTRSKjS1dE3t8ojAsVqjVoo7atYKjNEtNYI20rSSN6alCOsKABUqx8Ux-b73Hed1j43DYYrQ2TH6HuKTDeDt-5fBb-0m7KzignEjssHXF4MYHmZMk-19cpjXMmCYk2W6YqquJNMZPdujeXcpRWwPbRi1_5KyOSmr7T6pjH95-7UD_JqL-AvaN5Id</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1861576418</pqid></control><display><type>article</type><title>Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Salas, Matthias ; Augustin, Marco ; Ginner, Laurin ; Kumar, Abhishek ; Baumann, Bernhard ; Leitgeb, Rainer ; Drexler, Wolfgang ; Prager, Sonja ; Hafner, Julia ; Schmidt-Erfurth, Ursula ; Pircher, Michael</creator><creatorcontrib>Salas, Matthias ; Augustin, Marco ; Ginner, Laurin ; Kumar, Abhishek ; Baumann, Bernhard ; Leitgeb, Rainer ; Drexler, Wolfgang ; Prager, Sonja ; Hafner, Julia ; Schmidt-Erfurth, Ursula ; Pircher, Michael</creatorcontrib><description>The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.</description><identifier>ISSN: 2156-7085</identifier><identifier>EISSN: 2156-7085</identifier><identifier>DOI: 10.1364/BOE.8.000207</identifier><identifier>PMID: 28101412</identifier><language>eng</language><publisher>United States: Optical Society of America</publisher><ispartof>Biomedical optics express, 2017-01, Vol.8 (1), p.207-222</ispartof><rights>2016 Optical Society of America 2016 Optical Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-7349445e974cd7c002a2e6be8552c09b5a998f0930d49f42d9f0eab6aae5e5c23</citedby><cites>FETCH-LOGICAL-c384t-7349445e974cd7c002a2e6be8552c09b5a998f0930d49f42d9f0eab6aae5e5c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231293/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231293/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28101412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salas, Matthias</creatorcontrib><creatorcontrib>Augustin, Marco</creatorcontrib><creatorcontrib>Ginner, Laurin</creatorcontrib><creatorcontrib>Kumar, Abhishek</creatorcontrib><creatorcontrib>Baumann, Bernhard</creatorcontrib><creatorcontrib>Leitgeb, Rainer</creatorcontrib><creatorcontrib>Drexler, Wolfgang</creatorcontrib><creatorcontrib>Prager, Sonja</creatorcontrib><creatorcontrib>Hafner, Julia</creatorcontrib><creatorcontrib>Schmidt-Erfurth, Ursula</creatorcontrib><creatorcontrib>Pircher, Michael</creatorcontrib><title>Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics</title><title>Biomedical optics express</title><addtitle>Biomed Opt Express</addtitle><description>The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.</description><issn>2156-7085</issn><issn>2156-7085</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkc1P3DAQxa2KqrsCbj1XOfZAtv5M7EslQPRDQuJSuFqzzmTXKImDnSyCv75uF1Zw8pP9mzeeeYR8ZnTFRCW_XdxcrfSKUspp_YEsOVNVWVOtjt7oBTlN6T4zVMqaCv2JLLhmlEnGlyTe-TRD559h8mEoQlv03sVQOhh910H0mIo5-WFThHHyDrrChS1GHBwWU-jDJsK4fSpg2PhX_einbb5o_oswTwU0kGt3uLdIJ-RjC13C05fzmNz-uPpz-au8vvn5-_L8unRCy6mshTRSKjS1dE3t8ojAsVqjVoo7atYKjNEtNYI20rSSN6alCOsKABUqx8Ux-b73Hed1j43DYYrQ2TH6HuKTDeDt-5fBb-0m7KzignEjssHXF4MYHmZMk-19cpjXMmCYk2W6YqquJNMZPdujeXcpRWwPbRi1_5KyOSmr7T6pjH95-7UD_JqL-AvaN5Id</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Salas, Matthias</creator><creator>Augustin, Marco</creator><creator>Ginner, Laurin</creator><creator>Kumar, Abhishek</creator><creator>Baumann, Bernhard</creator><creator>Leitgeb, Rainer</creator><creator>Drexler, Wolfgang</creator><creator>Prager, Sonja</creator><creator>Hafner, Julia</creator><creator>Schmidt-Erfurth, Ursula</creator><creator>Pircher, Michael</creator><general>Optical Society of America</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics</title><author>Salas, Matthias ; Augustin, Marco ; Ginner, Laurin ; Kumar, Abhishek ; Baumann, Bernhard ; Leitgeb, Rainer ; Drexler, Wolfgang ; Prager, Sonja ; Hafner, Julia ; Schmidt-Erfurth, Ursula ; Pircher, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-7349445e974cd7c002a2e6be8552c09b5a998f0930d49f42d9f0eab6aae5e5c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salas, Matthias</creatorcontrib><creatorcontrib>Augustin, Marco</creatorcontrib><creatorcontrib>Ginner, Laurin</creatorcontrib><creatorcontrib>Kumar, Abhishek</creatorcontrib><creatorcontrib>Baumann, Bernhard</creatorcontrib><creatorcontrib>Leitgeb, Rainer</creatorcontrib><creatorcontrib>Drexler, Wolfgang</creatorcontrib><creatorcontrib>Prager, Sonja</creatorcontrib><creatorcontrib>Hafner, Julia</creatorcontrib><creatorcontrib>Schmidt-Erfurth, Ursula</creatorcontrib><creatorcontrib>Pircher, Michael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedical optics express</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salas, Matthias</au><au>Augustin, Marco</au><au>Ginner, Laurin</au><au>Kumar, Abhishek</au><au>Baumann, Bernhard</au><au>Leitgeb, Rainer</au><au>Drexler, Wolfgang</au><au>Prager, Sonja</au><au>Hafner, Julia</au><au>Schmidt-Erfurth, Ursula</au><au>Pircher, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics</atitle><jtitle>Biomedical optics express</jtitle><addtitle>Biomed Opt Express</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>8</volume><issue>1</issue><spage>207</spage><epage>222</epage><pages>207-222</pages><issn>2156-7085</issn><eissn>2156-7085</eissn><abstract>The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.</abstract><cop>United States</cop><pub>Optical Society of America</pub><pmid>28101412</pmid><doi>10.1364/BOE.8.000207</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2156-7085
ispartof Biomedical optics express, 2017-01, Vol.8 (1), p.207-222
issn 2156-7085
2156-7085
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5231293
source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A21%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Visualization%20of%20micro-capillaries%20using%20optical%20coherence%20tomography%20angiography%20with%20and%20without%20adaptive%20optics&rft.jtitle=Biomedical%20optics%20express&rft.au=Salas,%20Matthias&rft.date=2017-01-01&rft.volume=8&rft.issue=1&rft.spage=207&rft.epage=222&rft.pages=207-222&rft.issn=2156-7085&rft.eissn=2156-7085&rft_id=info:doi/10.1364/BOE.8.000207&rft_dat=%3Cproquest_pubme%3E1861576418%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1861576418&rft_id=info:pmid/28101412&rfr_iscdi=true