Brazilian Sepsis Epidemiological Study (BASES study)
Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Confe...
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| Veröffentlicht in: | Critical care (London, England) England), 2004-08, Vol.8 (4), p.R251-R260, Article R251 |
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| creator | Silva, Eliézer Pedro, Marcelo de Almeida Sogayar, Ana Cristina Beltrami Mohovic, Tatiana Silva, Carla Lika de Oliveira Janiszewski, Mariano Cal, Ruy Guilherme Rodrigues de Sousa, Erica Fernandes Abe, Thereza Phitoe de Andrade, Joel de Matos, Jorge Dias Rezende, Ederlon Assunção, Murillo Avezum, Alvaro Rocha, Patrícia C S de Matos, Gustavo Faissol Janot Bento, André Moreira Corrêa, Alice Danielli Vieira, Paulo Cesar Bastos Knobel, Elias |
| description | Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome
This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.
For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.
Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate. |
| doi_str_mv | 10.1186/cc2892 |
| format | Article |
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This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.
For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.
Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate.</description><identifier>ISSN: 1364-8535</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>DOI: 10.1186/cc2892</identifier><identifier>PMID: 15312226</identifier><language>eng</language><publisher>England: National Library of Medicine - MEDLINE Abstracts</publisher><subject>Aged ; APACHE ; Brazil - epidemiology ; Cohort Studies ; Community-Acquired Infections - epidemiology ; Cross Infection - epidemiology ; Hospital Mortality ; Hospitals, Private ; Hospitals, Public ; Humans ; Intensive Care Units - statistics & numerical data ; Middle Aged ; Multiple Organ Failure - epidemiology ; Multiple Organ Failure - mortality ; Prospective Studies ; Sepsis - epidemiology ; Sepsis - mortality ; Shock, Septic - epidemiology ; Shock, Septic - mortality ; Spain - epidemiology ; Systemic Inflammatory Response Syndrome - epidemiology ; Systemic Inflammatory Response Syndrome - mortality</subject><ispartof>Critical care (London, England), 2004-08, Vol.8 (4), p.R251-R260, Article R251</ispartof><rights>Copyright National Library of Medicine - MEDLINE Abstracts Aug 2004</rights><rights>Copyright © 2004 Silva et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b504t-186a3bd7360ef0a03725dbdf3ae7d9755e9f74939999e590ff1d5af64abdfa073</citedby><cites>FETCH-LOGICAL-b504t-186a3bd7360ef0a03725dbdf3ae7d9755e9f74939999e590ff1d5af64abdfa073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC522852/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC522852/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15312226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Eliézer</creatorcontrib><creatorcontrib>Pedro, Marcelo de Almeida</creatorcontrib><creatorcontrib>Sogayar, Ana Cristina Beltrami</creatorcontrib><creatorcontrib>Mohovic, Tatiana</creatorcontrib><creatorcontrib>Silva, Carla Lika de Oliveira</creatorcontrib><creatorcontrib>Janiszewski, Mariano</creatorcontrib><creatorcontrib>Cal, Ruy Guilherme Rodrigues</creatorcontrib><creatorcontrib>de Sousa, Erica Fernandes</creatorcontrib><creatorcontrib>Abe, Thereza Phitoe</creatorcontrib><creatorcontrib>de Andrade, Joel</creatorcontrib><creatorcontrib>de Matos, Jorge Dias</creatorcontrib><creatorcontrib>Rezende, Ederlon</creatorcontrib><creatorcontrib>Assunção, Murillo</creatorcontrib><creatorcontrib>Avezum, Alvaro</creatorcontrib><creatorcontrib>Rocha, Patrícia C S</creatorcontrib><creatorcontrib>de Matos, Gustavo Faissol Janot</creatorcontrib><creatorcontrib>Bento, André Moreira</creatorcontrib><creatorcontrib>Corrêa, Alice Danielli</creatorcontrib><creatorcontrib>Vieira, Paulo Cesar Bastos</creatorcontrib><creatorcontrib>Knobel, Elias</creatorcontrib><creatorcontrib>Brazilian Sepsis Epidemiological Study</creatorcontrib><title>Brazilian Sepsis Epidemiological Study (BASES study)</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome
This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.
For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.
Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate.</description><subject>Aged</subject><subject>APACHE</subject><subject>Brazil - epidemiology</subject><subject>Cohort Studies</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Cross Infection - epidemiology</subject><subject>Hospital Mortality</subject><subject>Hospitals, Private</subject><subject>Hospitals, Public</subject><subject>Humans</subject><subject>Intensive Care Units - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Multiple Organ Failure - epidemiology</subject><subject>Multiple Organ Failure - mortality</subject><subject>Prospective Studies</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - mortality</subject><subject>Shock, Septic - epidemiology</subject><subject>Shock, Septic - mortality</subject><subject>Spain - epidemiology</subject><subject>Systemic Inflammatory Response Syndrome - epidemiology</subject><subject>Systemic Inflammatory Response Syndrome - mortality</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UUtLw0AQXkSxWvUnSPAgeojuI7ubPXhoS31AwUMUvC2bZLduSbIxmwj115vSYq3gXGaG-b5vXgCcIXiDUMxuswzHAu-BIxQxFjIo3vb7mLAojCmhA3Ds_QJCxGNGDsEAUYIwxuwIRONGfdnCqipIdO2tD6a1zXVpXeHmNlNFkLRdvgyuxqNkmgR-lVyfgAOjCq9PN34IXu-nL5PHcPb88DQZzcKUwqgN-7kUSXNOGNQGKkg4pnmaG6I0zwWnVAvDI0FEb5oKaAzKqTIsUj1IQU6G4G6tW3dpqfNMV22jClk3tlTNUjpl5W6lsu9y7j4lxTimuOeLNT-17h_-biVzpVxfsudebno37qPTvpWl9ZkuClVp13nJGBeIRXEPvPgDXLiuqfq7SCRoRDkX8VYta5z3jTY_QyAoVw_ctj3_vfIWtvkY-QYehZbi</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Silva, Eliézer</creator><creator>Pedro, Marcelo de Almeida</creator><creator>Sogayar, Ana Cristina Beltrami</creator><creator>Mohovic, Tatiana</creator><creator>Silva, Carla Lika de Oliveira</creator><creator>Janiszewski, Mariano</creator><creator>Cal, Ruy Guilherme Rodrigues</creator><creator>de Sousa, Erica Fernandes</creator><creator>Abe, Thereza Phitoe</creator><creator>de Andrade, Joel</creator><creator>de Matos, Jorge Dias</creator><creator>Rezende, Ederlon</creator><creator>Assunção, Murillo</creator><creator>Avezum, Alvaro</creator><creator>Rocha, Patrícia C S</creator><creator>de Matos, Gustavo Faissol Janot</creator><creator>Bento, André Moreira</creator><creator>Corrêa, Alice Danielli</creator><creator>Vieira, Paulo Cesar Bastos</creator><creator>Knobel, Elias</creator><general>National Library of Medicine - MEDLINE Abstracts</general><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040801</creationdate><title>Brazilian Sepsis Epidemiological Study (BASES study)</title><author>Silva, Eliézer ; 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This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome
This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.
For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.
Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate.</abstract><cop>England</cop><pub>National Library of Medicine - MEDLINE Abstracts</pub><pmid>15312226</pmid><doi>10.1186/cc2892</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Critical care (London, England), 2004-08, Vol.8 (4), p.R251-R260, Article R251 |
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| source | MEDLINE; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged APACHE Brazil - epidemiology Cohort Studies Community-Acquired Infections - epidemiology Cross Infection - epidemiology Hospital Mortality Hospitals, Private Hospitals, Public Humans Intensive Care Units - statistics & numerical data Middle Aged Multiple Organ Failure - epidemiology Multiple Organ Failure - mortality Prospective Studies Sepsis - epidemiology Sepsis - mortality Shock, Septic - epidemiology Shock, Septic - mortality Spain - epidemiology Systemic Inflammatory Response Syndrome - epidemiology Systemic Inflammatory Response Syndrome - mortality |
| title | Brazilian Sepsis Epidemiological Study (BASES study) |
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