The state of melanoma: challenges and opportunities
Summary The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused o...
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| Veröffentlicht in: | Pigment cell and melanoma research 2016-07, Vol.29 (4), p.404-416 |
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| container_title | Pigment cell and melanoma research |
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| creator | Merlino, Glenn Herlyn, Meenhard Fisher, David E. Bastian, Boris C. Flaherty, Keith T. Davies, Michael A. Wargo, Jennifer A. Curiel-Lewandrowski, Clara Weber, Michael J. Leachman, Sancy A. Soengas, Maria S. McMahon, Martin Harbour, J. William Swetter, Susan M. Aplin, Andrew E. Atkins, Michael B. Bosenberg, Marcus W. Dummer, Reinhard Gershenwald, Jeffrey E. Halpern, Allan C. Herlyn, Dorothee Karakousis, Giorgos C. Kirkwood, John M. Krauthammer, Michael Lo, Roger S. Long, Georgina V. McArthur, Grant Ribas, Antoni Schuchter, Lynn Sosman, Jeffrey A. Smalley, Keiran S. Steeg, Patricia Thomas, Nancy E. Tsao, Hensin Tueting, Thomas Weeraratna, Ashani Xu, George Lomax, Randy Martin, Alison Silverstein, Steve Turnham, Tim Ronai, Ze'ev A. |
| description | Summary
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long‐term needs of the melanoma field, from basic research to clinical management, are presented in the following report. |
| doi_str_mv | 10.1111/pcmr.12475 |
| format | Article |
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The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long‐term needs of the melanoma field, from basic research to clinical management, are presented in the following report.</description><identifier>ISSN: 1755-1471</identifier><identifier>EISSN: 1755-148X</identifier><identifier>DOI: 10.1111/pcmr.12475</identifier><identifier>PMID: 27087480</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Biomedical Research ; dormancy ; early diagnosis ; Humans ; Melanoma ; Melanoma - diagnosis ; Melanoma - therapy ; metastasis ; prevention ; Signal Transduction ; Societies, Scientific ; therapy</subject><ispartof>Pigment cell and melanoma research, 2016-07, Vol.29 (4), p.404-416</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5565-4b54fb3a40596c4f506bfe9f0a152391be1e88c3ad301cf24aa4e54715d02dcb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcmr.12475$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcmr.12475$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27087480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merlino, Glenn</creatorcontrib><creatorcontrib>Herlyn, Meenhard</creatorcontrib><creatorcontrib>Fisher, David E.</creatorcontrib><creatorcontrib>Bastian, Boris C.</creatorcontrib><creatorcontrib>Flaherty, Keith T.</creatorcontrib><creatorcontrib>Davies, Michael A.</creatorcontrib><creatorcontrib>Wargo, Jennifer A.</creatorcontrib><creatorcontrib>Curiel-Lewandrowski, Clara</creatorcontrib><creatorcontrib>Weber, Michael J.</creatorcontrib><creatorcontrib>Leachman, Sancy A.</creatorcontrib><creatorcontrib>Soengas, Maria S.</creatorcontrib><creatorcontrib>McMahon, Martin</creatorcontrib><creatorcontrib>Harbour, J. William</creatorcontrib><creatorcontrib>Swetter, Susan M.</creatorcontrib><creatorcontrib>Aplin, Andrew E.</creatorcontrib><creatorcontrib>Atkins, Michael B.</creatorcontrib><creatorcontrib>Bosenberg, Marcus W.</creatorcontrib><creatorcontrib>Dummer, Reinhard</creatorcontrib><creatorcontrib>Gershenwald, Jeffrey E.</creatorcontrib><creatorcontrib>Halpern, Allan C.</creatorcontrib><creatorcontrib>Herlyn, Dorothee</creatorcontrib><creatorcontrib>Karakousis, Giorgos C.</creatorcontrib><creatorcontrib>Kirkwood, John M.</creatorcontrib><creatorcontrib>Krauthammer, Michael</creatorcontrib><creatorcontrib>Lo, Roger S.</creatorcontrib><creatorcontrib>Long, Georgina V.</creatorcontrib><creatorcontrib>McArthur, Grant</creatorcontrib><creatorcontrib>Ribas, Antoni</creatorcontrib><creatorcontrib>Schuchter, Lynn</creatorcontrib><creatorcontrib>Sosman, Jeffrey A.</creatorcontrib><creatorcontrib>Smalley, Keiran S.</creatorcontrib><creatorcontrib>Steeg, Patricia</creatorcontrib><creatorcontrib>Thomas, Nancy E.</creatorcontrib><creatorcontrib>Tsao, Hensin</creatorcontrib><creatorcontrib>Tueting, Thomas</creatorcontrib><creatorcontrib>Weeraratna, Ashani</creatorcontrib><creatorcontrib>Xu, George</creatorcontrib><creatorcontrib>Lomax, Randy</creatorcontrib><creatorcontrib>Martin, Alison</creatorcontrib><creatorcontrib>Silverstein, Steve</creatorcontrib><creatorcontrib>Turnham, Tim</creatorcontrib><creatorcontrib>Ronai, Ze'ev A.</creatorcontrib><title>The state of melanoma: challenges and opportunities</title><title>Pigment cell and melanoma research</title><addtitle>Pigment Cell Melanoma Res</addtitle><description>Summary
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long‐term needs of the melanoma field, from basic research to clinical management, are presented in the following report.</description><subject>Biomedical Research</subject><subject>dormancy</subject><subject>early diagnosis</subject><subject>Humans</subject><subject>Melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - therapy</subject><subject>metastasis</subject><subject>prevention</subject><subject>Signal Transduction</subject><subject>Societies, Scientific</subject><subject>therapy</subject><issn>1755-1471</issn><issn>1755-148X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtP3DAUhS1EBXTopj8AReoGIQX8jJ0ukNAIaFUeFRoEO8txbphAEgc7KfDv6-nAqO0Cb2zJ3z333HsQ-kzwPonnoLet3yeUS7GGtogUIiVc3a6v3pJsoo8h3GOcYZGzDbRJJVaSK7yF2GwOSRjMAImrkhYa07nWfE3s3DQNdHcQEtOViet754exq4cawjb6UJkmwKfXe4KuT45n02_p2eXp9-nRWWqFyETKC8Grghkem2aWVwJnRQV5hQ0RlOWkAAJKWWZKhomtKDeGg4huRYlpaQs2QYdL3X4sWigtdIM3je593Rr_op2p9b8_XT3Xd-6XFpQqrmQU2H0V8O5xhDDotg4WmjgkuDFoInMlKV0sZYK-_Ifeu9F3cbwFJVVGSC4itbekrHcheKhWZgjWiyz0Igv9J4sI7_xtf4W-LT8CZAk81Q28vCOlf07Pr95E02VNHQZ4XtUY_6AzySJ6c3Gqb2bTH-Lk6kJn7Dehc6N-</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Merlino, Glenn</creator><creator>Herlyn, Meenhard</creator><creator>Fisher, David E.</creator><creator>Bastian, Boris C.</creator><creator>Flaherty, Keith T.</creator><creator>Davies, Michael A.</creator><creator>Wargo, Jennifer A.</creator><creator>Curiel-Lewandrowski, Clara</creator><creator>Weber, Michael J.</creator><creator>Leachman, Sancy A.</creator><creator>Soengas, Maria S.</creator><creator>McMahon, Martin</creator><creator>Harbour, J. William</creator><creator>Swetter, Susan M.</creator><creator>Aplin, Andrew E.</creator><creator>Atkins, Michael B.</creator><creator>Bosenberg, Marcus W.</creator><creator>Dummer, Reinhard</creator><creator>Gershenwald, Jeffrey E.</creator><creator>Halpern, Allan C.</creator><creator>Herlyn, Dorothee</creator><creator>Karakousis, Giorgos C.</creator><creator>Kirkwood, John M.</creator><creator>Krauthammer, Michael</creator><creator>Lo, Roger S.</creator><creator>Long, Georgina V.</creator><creator>McArthur, Grant</creator><creator>Ribas, Antoni</creator><creator>Schuchter, Lynn</creator><creator>Sosman, Jeffrey A.</creator><creator>Smalley, Keiran S.</creator><creator>Steeg, Patricia</creator><creator>Thomas, Nancy E.</creator><creator>Tsao, Hensin</creator><creator>Tueting, Thomas</creator><creator>Weeraratna, Ashani</creator><creator>Xu, George</creator><creator>Lomax, Randy</creator><creator>Martin, Alison</creator><creator>Silverstein, Steve</creator><creator>Turnham, Tim</creator><creator>Ronai, Ze'ev A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201607</creationdate><title>The state of melanoma: challenges and opportunities</title><author>Merlino, Glenn ; Herlyn, Meenhard ; Fisher, David E. ; Bastian, Boris C. ; Flaherty, Keith T. ; Davies, Michael A. ; Wargo, Jennifer A. ; Curiel-Lewandrowski, Clara ; Weber, Michael J. ; Leachman, Sancy A. ; Soengas, Maria S. ; McMahon, Martin ; Harbour, J. William ; Swetter, Susan M. ; Aplin, Andrew E. ; Atkins, Michael B. ; Bosenberg, Marcus W. ; Dummer, Reinhard ; Gershenwald, Jeffrey E. ; Halpern, Allan C. ; Herlyn, Dorothee ; Karakousis, Giorgos C. ; Kirkwood, John M. ; Krauthammer, Michael ; Lo, Roger S. ; Long, Georgina V. ; McArthur, Grant ; Ribas, Antoni ; Schuchter, Lynn ; Sosman, Jeffrey A. ; Smalley, Keiran S. ; Steeg, Patricia ; Thomas, Nancy E. ; Tsao, Hensin ; Tueting, Thomas ; Weeraratna, Ashani ; Xu, George ; Lomax, Randy ; Martin, Alison ; Silverstein, Steve ; Turnham, Tim ; Ronai, Ze'ev A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5565-4b54fb3a40596c4f506bfe9f0a152391be1e88c3ad301cf24aa4e54715d02dcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomedical Research</topic><topic>dormancy</topic><topic>early diagnosis</topic><topic>Humans</topic><topic>Melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - therapy</topic><topic>metastasis</topic><topic>prevention</topic><topic>Signal Transduction</topic><topic>Societies, Scientific</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merlino, Glenn</creatorcontrib><creatorcontrib>Herlyn, Meenhard</creatorcontrib><creatorcontrib>Fisher, David E.</creatorcontrib><creatorcontrib>Bastian, Boris C.</creatorcontrib><creatorcontrib>Flaherty, Keith T.</creatorcontrib><creatorcontrib>Davies, Michael A.</creatorcontrib><creatorcontrib>Wargo, Jennifer A.</creatorcontrib><creatorcontrib>Curiel-Lewandrowski, Clara</creatorcontrib><creatorcontrib>Weber, Michael J.</creatorcontrib><creatorcontrib>Leachman, Sancy A.</creatorcontrib><creatorcontrib>Soengas, Maria S.</creatorcontrib><creatorcontrib>McMahon, Martin</creatorcontrib><creatorcontrib>Harbour, J. William</creatorcontrib><creatorcontrib>Swetter, Susan M.</creatorcontrib><creatorcontrib>Aplin, Andrew E.</creatorcontrib><creatorcontrib>Atkins, Michael B.</creatorcontrib><creatorcontrib>Bosenberg, Marcus W.</creatorcontrib><creatorcontrib>Dummer, Reinhard</creatorcontrib><creatorcontrib>Gershenwald, Jeffrey E.</creatorcontrib><creatorcontrib>Halpern, Allan C.</creatorcontrib><creatorcontrib>Herlyn, Dorothee</creatorcontrib><creatorcontrib>Karakousis, Giorgos C.</creatorcontrib><creatorcontrib>Kirkwood, John M.</creatorcontrib><creatorcontrib>Krauthammer, Michael</creatorcontrib><creatorcontrib>Lo, Roger S.</creatorcontrib><creatorcontrib>Long, Georgina V.</creatorcontrib><creatorcontrib>McArthur, Grant</creatorcontrib><creatorcontrib>Ribas, Antoni</creatorcontrib><creatorcontrib>Schuchter, Lynn</creatorcontrib><creatorcontrib>Sosman, Jeffrey A.</creatorcontrib><creatorcontrib>Smalley, Keiran S.</creatorcontrib><creatorcontrib>Steeg, Patricia</creatorcontrib><creatorcontrib>Thomas, Nancy E.</creatorcontrib><creatorcontrib>Tsao, Hensin</creatorcontrib><creatorcontrib>Tueting, Thomas</creatorcontrib><creatorcontrib>Weeraratna, Ashani</creatorcontrib><creatorcontrib>Xu, George</creatorcontrib><creatorcontrib>Lomax, Randy</creatorcontrib><creatorcontrib>Martin, Alison</creatorcontrib><creatorcontrib>Silverstein, Steve</creatorcontrib><creatorcontrib>Turnham, Tim</creatorcontrib><creatorcontrib>Ronai, Ze'ev A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pigment cell and melanoma research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merlino, Glenn</au><au>Herlyn, Meenhard</au><au>Fisher, David E.</au><au>Bastian, Boris C.</au><au>Flaherty, Keith T.</au><au>Davies, Michael A.</au><au>Wargo, Jennifer A.</au><au>Curiel-Lewandrowski, Clara</au><au>Weber, Michael J.</au><au>Leachman, Sancy A.</au><au>Soengas, Maria S.</au><au>McMahon, Martin</au><au>Harbour, J. William</au><au>Swetter, Susan M.</au><au>Aplin, Andrew E.</au><au>Atkins, Michael B.</au><au>Bosenberg, Marcus W.</au><au>Dummer, Reinhard</au><au>Gershenwald, Jeffrey E.</au><au>Halpern, Allan C.</au><au>Herlyn, Dorothee</au><au>Karakousis, Giorgos C.</au><au>Kirkwood, John M.</au><au>Krauthammer, Michael</au><au>Lo, Roger S.</au><au>Long, Georgina V.</au><au>McArthur, Grant</au><au>Ribas, Antoni</au><au>Schuchter, Lynn</au><au>Sosman, Jeffrey A.</au><au>Smalley, Keiran S.</au><au>Steeg, Patricia</au><au>Thomas, Nancy E.</au><au>Tsao, Hensin</au><au>Tueting, Thomas</au><au>Weeraratna, Ashani</au><au>Xu, George</au><au>Lomax, Randy</au><au>Martin, Alison</au><au>Silverstein, Steve</au><au>Turnham, Tim</au><au>Ronai, Ze'ev A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The state of melanoma: challenges and opportunities</atitle><jtitle>Pigment cell and melanoma research</jtitle><addtitle>Pigment Cell Melanoma Res</addtitle><date>2016-07</date><risdate>2016</risdate><volume>29</volume><issue>4</issue><spage>404</spage><epage>416</epage><pages>404-416</pages><issn>1755-1471</issn><eissn>1755-148X</eissn><abstract>Summary
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long‐term needs of the melanoma field, from basic research to clinical management, are presented in the following report.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27087480</pmid><doi>10.1111/pcmr.12475</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1755-1471 |
| ispartof | Pigment cell and melanoma research, 2016-07, Vol.29 (4), p.404-416 |
| issn | 1755-1471 1755-148X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biomedical Research dormancy early diagnosis Humans Melanoma Melanoma - diagnosis Melanoma - therapy metastasis prevention Signal Transduction Societies, Scientific therapy |
| title | The state of melanoma: challenges and opportunities |
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