Detection of Isoniazid-, Fluoroquinolone-, Amikacin-, and Kanamycin-Resistant Tuberculosis in an Automated, Multiplexed 10-Color Assay Suitable for Point-of-Care Use

Extensively drug-resistant (XDR) tuberculosis (TB) cannot be easily or quickly diagnosed. We developed a rapid, automated assay for the detection of XDR-TB plus resistance to the drug isoniazid (INH) for point-of-care use. Using a simple filter-based cartridge with an integrated sample processing fu...

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Veröffentlicht in:	Journal of clinical microbiology 2017-01, Vol.55 (1), p.183-198
Hauptverfasser:	Chakravorty, Soumitesh, Roh, Sandy S, Glass, Jennifer, Smith, Laura E, Simmons, Ann Marie, Lund, Kevin, Lokhov, Sergey, Liu, Xin, Xu, Peng, Zhang, Guolong, Via, Laura E, Shen, Qingyu, Ruan, Xianglin, Yuan, Xing, Zhu, Hong Zhu, Viazovkina, Ekaterina, Shenai, Shubhada, Rowneki, Mazhgan, Lee, Jong Seok, Barry, 3rd, Clifton E, Gao, Qian, Persing, David, Kwiatkawoski, Robert, Jones, Martin, Gall, Alexander, Alland, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amikacin - pharmacology Antitubercular Agents - pharmacology Automation, Laboratory - methods DNA, Bacterial - genetics Extensively Drug-Resistant Tuberculosis - diagnosis Extensively Drug-Resistant Tuberculosis - microbiology Fluoroquinolones - pharmacology Genes, Bacterial Humans Isoniazid - pharmacology Kanamycin - pharmacology Molecular Diagnostic Techniques - methods Mycobacteriology and Aerobic Actinomycetes Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Point-of-Care Systems Polymerase Chain Reaction - methods Sensitivity and Specificity
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