Topically applied vitamin C increases the density of dermal papillae in aged human skin
The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM) in vivo. The age dependency of the pa...
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| Veröffentlicht in: | BMC dermatology 2004-09, Vol.4 (1), p.13-13, Article 13 |
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| creator | Sauermann, Kirsten Jaspers, Sören Koop, Urte Wenck, Horst |
| description | The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM) in vivo.
The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women.
There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies.
Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process. |
| doi_str_mv | 10.1186/1471-5945-4-13 |
| format | Article |
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The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women.
There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies.
Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process.</description><identifier>ISSN: 1471-5945</identifier><identifier>EISSN: 1471-5945</identifier><identifier>DOI: 10.1186/1471-5945-4-13</identifier><identifier>PMID: 15456516</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Administration, Topical ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Dermis - ultrastructure ; Female ; Forearm ; Humans ; Middle Aged ; Neovascularization, Physiologic - drug effects ; Reference Values ; Reproducibility of Results ; Skin - drug effects ; Skin - pathology ; Skin Aging - drug effects ; Skin Aging - pathology ; Vitamin A - administration & dosage</subject><ispartof>BMC dermatology, 2004-09, Vol.4 (1), p.13-13, Article 13</ispartof><rights>Copyright © 2004 Sauermann et al; licensee BioMed Central Ltd. 2004 Sauermann et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3603-2055f09e200546e82ffcc3e7831af236676d24d2ee0e2494f164fbba7afdb1743</citedby><cites>FETCH-LOGICAL-b3603-2055f09e200546e82ffcc3e7831af236676d24d2ee0e2494f164fbba7afdb1743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC522805/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC522805/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,24801,27924,27925,53791,53793,75738,75739</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15456516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauermann, Kirsten</creatorcontrib><creatorcontrib>Jaspers, Sören</creatorcontrib><creatorcontrib>Koop, Urte</creatorcontrib><creatorcontrib>Wenck, Horst</creatorcontrib><title>Topically applied vitamin C increases the density of dermal papillae in aged human skin</title><title>BMC dermatology</title><addtitle>BMC Dermatol</addtitle><description>The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM) in vivo.
The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women.
There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies.
Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process.</description><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Dermis - ultrastructure</subject><subject>Female</subject><subject>Forearm</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin Aging - drug effects</subject><subject>Skin Aging - pathology</subject><subject>Vitamin A - administration & dosage</subject><issn>1471-5945</issn><issn>1471-5945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1Lw0AQXUSxtXr1KHvylrrfSQ4eSvELCl4qHpdNMtuuJtmYTQv996a0VIt4mmHmvTczbxC6pmRMaaLuqIhpJFMhIxFRfoKGh8Lpr3yALkL4IITGCZXnaEClkEpSNUTvc9-43JTlBpumKR0UeO06U7kaT7Gr8xZMgIC7JeAC6uC6Dfa2T9vKlLgxjStLAz0Qm0VPXa4qU-Pw6epLdGZNGeBqH0fo7fFhPn2OZq9PL9PJLMq4IjxiREpLUmCESKEgYdbmOYc44dRYxpWKVcFEwQAIMJEKS5WwWWZiY4uMxoKP0P1Ot1llFRQ51F1rSt20rjLtRnvj9HGndku98GstGUuI7PmTHT9z_h_-cSf3ld76qre-aqEp7zVu9zu0_msFodOVCzn0ztTgV0ErlSaMkrgHjnfAvPUhtGAPcyjR23f-Vb75fd0PfP8__g3vdJy9</recordid><startdate>20040929</startdate><enddate>20040929</enddate><creator>Sauermann, Kirsten</creator><creator>Jaspers, Sören</creator><creator>Koop, Urte</creator><creator>Wenck, Horst</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040929</creationdate><title>Topically applied vitamin C increases the density of dermal papillae in aged human skin</title><author>Sauermann, Kirsten ; Jaspers, Sören ; Koop, Urte ; Wenck, Horst</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3603-2055f09e200546e82ffcc3e7831af236676d24d2ee0e2494f164fbba7afdb1743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Dermis - ultrastructure</topic><topic>Female</topic><topic>Forearm</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin Aging - drug effects</topic><topic>Skin Aging - pathology</topic><topic>Vitamin A - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauermann, Kirsten</creatorcontrib><creatorcontrib>Jaspers, Sören</creatorcontrib><creatorcontrib>Koop, Urte</creatorcontrib><creatorcontrib>Wenck, Horst</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauermann, Kirsten</au><au>Jaspers, Sören</au><au>Koop, Urte</au><au>Wenck, Horst</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topically applied vitamin C increases the density of dermal papillae in aged human skin</atitle><jtitle>BMC dermatology</jtitle><addtitle>BMC Dermatol</addtitle><date>2004-09-29</date><risdate>2004</risdate><volume>4</volume><issue>1</issue><spage>13</spage><epage>13</epage><pages>13-13</pages><artnum>13</artnum><issn>1471-5945</issn><eissn>1471-5945</eissn><abstract>The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM) in vivo.
The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women.
There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies.
Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>15456516</pmid><doi>10.1186/1471-5945-4-13</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Topical Adolescent Adult Aged Aged, 80 and over Dermis - ultrastructure Female Forearm Humans Middle Aged Neovascularization, Physiologic - drug effects Reference Values Reproducibility of Results Skin - drug effects Skin - pathology Skin Aging - drug effects Skin Aging - pathology Vitamin A - administration & dosage |
| title | Topically applied vitamin C increases the density of dermal papillae in aged human skin |
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