Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells

Recent evidence suggest that a β-glucan derived from mushroom Schizophyllan(SPG) complexed with a humanized TLR9 agonistic CpG DNA, K3 (K3-SPG) is a promising vaccine adjuvant that induces robust CD8 T cell responses to co-administered antigen. However, it has not been investigated whether K3-SPG al...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (31), p.48860-48869
Hauptverfasser:	Kitahata, Yuji, Kanuma, Tomohiro, Hayashi, Masayuki, Kobayashi, Nobuyoshi, Ozasa, Koji, Kusakabe, Takato, Temizoz, Burcu, Kuroda, Etsushi, Yamaue, Hiroki, Coban, Cevayir, Yamamoto, Takuya, Kobiyama, Kouji, Aoshi, Taiki, Ishii, Ken J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Antibody Formation CD8-Positive T-Lymphocytes - immunology CpG Islands - drug effects Cytokines - pharmacology Humans Immunity, Innate Interferon Type I - pharmacology Interferon-gamma - immunology Interleukin-12 - immunology Leukocyte Common Antigens - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Nanoparticles - chemistry Neoplasms - blood Neoplasms - immunology Neoplasms - therapy Oligodeoxyribonucleotides - administration & dosage Phagocytosis Priority Research Paper Sizofiran - pharmacology Toll-Like Receptor 9 - agonists Tumor Microenvironment - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!