Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells
The adhesion of circulating blood cells to vascular endothelium may be an initial step in atherosclerosis, inflammation, and wound healing. One mechanism for promoting cell-cell adhesion involves the expression of adhesion molecules on the surface of the target cell. Herpes simplex virus infection o...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1991-08, Vol.88 (16), p.7200-7203 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7203 |
|---|---|
| container_issue | 16 |
| container_start_page | 7200 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 88 |
| creator | Etingin, Orli R. Silverstein, Roy L. Hajjar, David P. |
| description | The adhesion of circulating blood cells to vascular endothelium may be an initial step in atherosclerosis, inflammation, and wound healing. One mechanism for promoting cell-cell adhesion involves the expression of adhesion molecules on the surface of the target cell. Herpes simplex virus infection of endothelium induces arterial injury and has been implicated in the development of human atherosclerosis. We now demonstrate that HSV-infected endothelial cells express the adhesion molecule GMP140 and that this requires cell surface expression of HSV glycoprotein C and local thrombin generation. Monocyte adhesion to HSV-infected endothelial cells was completely inhibited by anti-GMP140 antibodies but not by antibodies to other adhesion molecules such as VCAM and ELAM-1. The induction of GMP140 expression on HSV-infected endothelium may be an important pathophysiological mechanism in virus-induced cell injury and inflammation. |
| doi_str_mv | 10.1073/pnas.88.16.7200 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_52261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2357649</jstor_id><sourcerecordid>2357649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c522t-63429a0e30913c4d226015e31293f8f28444b9142a7955e22938b6029e16ff703</originalsourceid><addsrcrecordid>eNqFks9rFDEUx4ModV09e1GZg9TTbPNrZhLoRZbaLlQKoueQzbzYlNlkTDLF_vdm2HW1FyWHQL6f98375gWh1wSvCO7Y2eh1WgmxIu2qoxg_QQuCJalbLvFTtMCYdrXglD9HL1K6wxjLRuATdEI6whtJF-hm04PPzjqjswu-CrbS1efgg3nIUH0BA2MOsSrKFcQR0r2LU6o33oLJ0FcXvg_5Fganh2oNw5BeomdWDwleHfYl-vbp4uv6qr6-udysP17XpqE01y3jVGoMrDTLDO8pbTFpgBEqmRWWCs75VhJOdSebBmg5FtsWUwmktbbDbInO977jtN1Bb0qIqAc1RrfT8UEF7dRjxbtb9T3cq3J9S0r56aE8hh8TpKx2LpkSQHsIU1LlLZksTfwXJKUpJspaorM9aGJIKYI99kKwmkel5lEpIUrJbD9HePt3hD_8fjZFf3_QdTJ6sFF749IR47KjrJ1t3h2w2f-3-uieD_8ElJ2GIcPPXMg3e_IulaEfUcqarnwo9gsD470Z</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16023838</pqid></control><display><type>article</type><title>Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells</title><source>MEDLINE</source><source>PubMed</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>JSTOR</source><creator>Etingin, Orli R. ; Silverstein, Roy L. ; Hajjar, David P.</creator><creatorcontrib>Etingin, Orli R. ; Silverstein, Roy L. ; Hajjar, David P.</creatorcontrib><description>The adhesion of circulating blood cells to vascular endothelium may be an initial step in atherosclerosis, inflammation, and wound healing. One mechanism for promoting cell-cell adhesion involves the expression of adhesion molecules on the surface of the target cell. Herpes simplex virus infection of endothelium induces arterial injury and has been implicated in the development of human atherosclerosis. We now demonstrate that HSV-infected endothelial cells express the adhesion molecule GMP140 and that this requires cell surface expression of HSV glycoprotein C and local thrombin generation. Monocyte adhesion to HSV-infected endothelial cells was completely inhibited by anti-GMP140 antibodies but not by antibodies to other adhesion molecules such as VCAM and ELAM-1. The induction of GMP140 expression on HSV-infected endothelium may be an important pathophysiological mechanism in virus-induced cell injury and inflammation.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.88.16.7200</identifier><identifier>PMID: 1714592</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Antibodies ; Biological and medical sciences ; Cell Adhesion ; Cell lines ; Cell Transformation, Viral ; Cells ; Endothelial cells ; endothelium ; Endothelium, Vascular - microbiology ; Endothelium, Vascular - physiology ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; herpes simplex virus 1 ; Human umbilical vein endothelial cells ; Humans ; Infections ; Kinetics ; Leukocytes ; Microbiology ; Monocytes ; Monocytes - physiology ; P-Selectin ; Platelet Membrane Glycoproteins - analysis ; Platelet Membrane Glycoproteins - genetics ; Platelet Membrane Glycoproteins - physiology ; Receptors ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Simplexvirus ; Simplexvirus - genetics ; Simplexvirus - physiology ; Thrombin - physiology ; Time Factors ; umbilical cord ; Umbilical Veins ; Viral Envelope Proteins - physiology ; Virology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1991-08, Vol.88 (16), p.7200-7203</ispartof><rights>Copyright 1991 The National Academy of Sciences of the United States of America</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-63429a0e30913c4d226015e31293f8f28444b9142a7955e22938b6029e16ff703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/88/16.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2357649$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2357649$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4972360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1714592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Etingin, Orli R.</creatorcontrib><creatorcontrib>Silverstein, Roy L.</creatorcontrib><creatorcontrib>Hajjar, David P.</creatorcontrib><title>Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The adhesion of circulating blood cells to vascular endothelium may be an initial step in atherosclerosis, inflammation, and wound healing. One mechanism for promoting cell-cell adhesion involves the expression of adhesion molecules on the surface of the target cell. Herpes simplex virus infection of endothelium induces arterial injury and has been implicated in the development of human atherosclerosis. We now demonstrate that HSV-infected endothelial cells express the adhesion molecule GMP140 and that this requires cell surface expression of HSV glycoprotein C and local thrombin generation. Monocyte adhesion to HSV-infected endothelial cells was completely inhibited by anti-GMP140 antibodies but not by antibodies to other adhesion molecules such as VCAM and ELAM-1. The induction of GMP140 expression on HSV-infected endothelium may be an important pathophysiological mechanism in virus-induced cell injury and inflammation.</description><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell lines</subject><subject>Cell Transformation, Viral</subject><subject>Cells</subject><subject>Endothelial cells</subject><subject>endothelium</subject><subject>Endothelium, Vascular - microbiology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>herpes simplex virus 1</subject><subject>Human umbilical vein endothelial cells</subject><subject>Humans</subject><subject>Infections</subject><subject>Kinetics</subject><subject>Leukocytes</subject><subject>Microbiology</subject><subject>Monocytes</subject><subject>Monocytes - physiology</subject><subject>P-Selectin</subject><subject>Platelet Membrane Glycoproteins - analysis</subject><subject>Platelet Membrane Glycoproteins - genetics</subject><subject>Platelet Membrane Glycoproteins - physiology</subject><subject>Receptors</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Simplexvirus</subject><subject>Simplexvirus - genetics</subject><subject>Simplexvirus - physiology</subject><subject>Thrombin - physiology</subject><subject>Time Factors</subject><subject>umbilical cord</subject><subject>Umbilical Veins</subject><subject>Viral Envelope Proteins - physiology</subject><subject>Virology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUx4ModV09e1GZg9TTbPNrZhLoRZbaLlQKoueQzbzYlNlkTDLF_vdm2HW1FyWHQL6f98375gWh1wSvCO7Y2eh1WgmxIu2qoxg_QQuCJalbLvFTtMCYdrXglD9HL1K6wxjLRuATdEI6whtJF-hm04PPzjqjswu-CrbS1efgg3nIUH0BA2MOsSrKFcQR0r2LU6o33oLJ0FcXvg_5Fganh2oNw5BeomdWDwleHfYl-vbp4uv6qr6-udysP17XpqE01y3jVGoMrDTLDO8pbTFpgBEqmRWWCs75VhJOdSebBmg5FtsWUwmktbbDbInO977jtN1Bb0qIqAc1RrfT8UEF7dRjxbtb9T3cq3J9S0r56aE8hh8TpKx2LpkSQHsIU1LlLZksTfwXJKUpJspaorM9aGJIKYI99kKwmkel5lEpIUrJbD9HePt3hD_8fjZFf3_QdTJ6sFF749IR47KjrJ1t3h2w2f-3-uieD_8ElJ2GIcPPXMg3e_IulaEfUcqarnwo9gsD470Z</recordid><startdate>19910815</startdate><enddate>19910815</enddate><creator>Etingin, Orli R.</creator><creator>Silverstein, Roy L.</creator><creator>Hajjar, David P.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910815</creationdate><title>Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells</title><author>Etingin, Orli R. ; Silverstein, Roy L. ; Hajjar, David P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-63429a0e30913c4d226015e31293f8f28444b9142a7955e22938b6029e16ff703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion</topic><topic>Cell lines</topic><topic>Cell Transformation, Viral</topic><topic>Cells</topic><topic>Endothelial cells</topic><topic>endothelium</topic><topic>Endothelium, Vascular - microbiology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>herpes simplex virus 1</topic><topic>Human umbilical vein endothelial cells</topic><topic>Humans</topic><topic>Infections</topic><topic>Kinetics</topic><topic>Leukocytes</topic><topic>Microbiology</topic><topic>Monocytes</topic><topic>Monocytes - physiology</topic><topic>P-Selectin</topic><topic>Platelet Membrane Glycoproteins - analysis</topic><topic>Platelet Membrane Glycoproteins - genetics</topic><topic>Platelet Membrane Glycoproteins - physiology</topic><topic>Receptors</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Simplexvirus</topic><topic>Simplexvirus - genetics</topic><topic>Simplexvirus - physiology</topic><topic>Thrombin - physiology</topic><topic>Time Factors</topic><topic>umbilical cord</topic><topic>Umbilical Veins</topic><topic>Viral Envelope Proteins - physiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Etingin, Orli R.</creatorcontrib><creatorcontrib>Silverstein, Roy L.</creatorcontrib><creatorcontrib>Hajjar, David P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Etingin, Orli R.</au><au>Silverstein, Roy L.</au><au>Hajjar, David P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1991-08-15</date><risdate>1991</risdate><volume>88</volume><issue>16</issue><spage>7200</spage><epage>7203</epage><pages>7200-7203</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The adhesion of circulating blood cells to vascular endothelium may be an initial step in atherosclerosis, inflammation, and wound healing. One mechanism for promoting cell-cell adhesion involves the expression of adhesion molecules on the surface of the target cell. Herpes simplex virus infection of endothelium induces arterial injury and has been implicated in the development of human atherosclerosis. We now demonstrate that HSV-infected endothelial cells express the adhesion molecule GMP140 and that this requires cell surface expression of HSV glycoprotein C and local thrombin generation. Monocyte adhesion to HSV-infected endothelial cells was completely inhibited by anti-GMP140 antibodies but not by antibodies to other adhesion molecules such as VCAM and ELAM-1. The induction of GMP140 expression on HSV-infected endothelium may be an important pathophysiological mechanism in virus-induced cell injury and inflammation.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1714592</pmid><doi>10.1073/pnas.88.16.7200</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1991-08, Vol.88 (16), p.7200-7203 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_52261 |
| source | MEDLINE; PubMed; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; JSTOR |
| subjects | Antibodies Biological and medical sciences Cell Adhesion Cell lines Cell Transformation, Viral Cells Endothelial cells endothelium Endothelium, Vascular - microbiology Endothelium, Vascular - physiology Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression herpes simplex virus 1 Human umbilical vein endothelial cells Humans Infections Kinetics Leukocytes Microbiology Monocytes Monocytes - physiology P-Selectin Platelet Membrane Glycoproteins - analysis Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - physiology Receptors Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Simplexvirus Simplexvirus - genetics Simplexvirus - physiology Thrombin - physiology Time Factors umbilical cord Umbilical Veins Viral Envelope Proteins - physiology Virology |
| title | Identification of a Monocyte Receptor on Herpesvirus-Infected Endothelial Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A54%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20a%20Monocyte%20Receptor%20on%20Herpesvirus-Infected%20Endothelial%20Cells&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Etingin,%20Orli%20R.&rft.date=1991-08-15&rft.volume=88&rft.issue=16&rft.spage=7200&rft.epage=7203&rft.pages=7200-7203&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.88.16.7200&rft_dat=%3Cjstor_pubme%3E2357649%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16023838&rft_id=info:pmid/1714592&rft_jstor_id=2357649&rfr_iscdi=true |