Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy

The lifesaving chemotherapy and radiation treatments that allow patients to survive cancer can also result in a lifetime of side-effects, including male infertility. Infertility in male cancer survivors is thought to primarily result from killing of the spermatogonial stem cells (SSCs) responsible f...

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Veröffentlicht in:	Reproductive biology and endocrinology 2017-01, Vol.15 (1), p.7-7, Article 7
Hauptverfasser:	Kotzur, Travis, Benavides-Garcia, Roberto, Mecklenburg, Jennifer, Sanchez, Jamila R, Reilly, Matthew, Hermann, Brian P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - toxicity Busulfan - toxicity Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Dose-Response Relationship, Drug Fluorescent Antibody Technique Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - pharmacology Humans Ki-67 Antigen - metabolism Kruppel-Like Transcription Factors - metabolism Male Mice, Inbred C57BL Promyelocytic Leukemia Zinc Finger Protein Protective Agents - pharmacology Regeneration - drug effects Spermatogenesis Spermatogenesis - drug effects Spermatogenesis - physiology Spermatogonia - cytology Spermatogonia - drug effects Spermatogonia - physiology Testis - cytology Testis - drug effects Testis - metabolism Time Factors
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