Evaluation of the point-of-care Becton Dickinson Veritor™ Rapid influenza diagnostic test in Kenya, 2013-2014
We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable. Nasal swa...
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| Veröffentlicht in: | BMC infectious diseases 2017-01, Vol.17 (1), p.60-60, Article 60 |
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| creator | Ndegwa, Linus K Emukule, Gideon Uyeki, Timothy M Mailu, Eunice Chaves, Sandra S Widdowson, Marc-Alain Lewa, Bandika V Muiruri, Francis K Omoth, Peter Fields, Barry Mott, Joshua A |
| description | We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable.
Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the RIDT using NS specimens were evaluated against nasal swabs tested by real time reverse transcription polymerase chain reaction (rRT-PCR). The performance parameter results were expressed as 95% confidence intervals (CI) calculated using binomial exact methods, with P < 0.05 considered significant. Two-sample Z tests were used to test for differences in sample proportions. Analysis was performed using SAS software version 9.3.
From July 2013 to July 2014, 3,569 patients were recruited, of which 78.7% were aged |
| doi_str_mv | 10.1186/s12879-016-2131-9 |
| format | Article |
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Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the RIDT using NS specimens were evaluated against nasal swabs tested by real time reverse transcription polymerase chain reaction (rRT-PCR). The performance parameter results were expressed as 95% confidence intervals (CI) calculated using binomial exact methods, with P < 0.05 considered significant. Two-sample Z tests were used to test for differences in sample proportions. Analysis was performed using SAS software version 9.3.
From July 2013 to July 2014, 3,569 patients were recruited, of which 78.7% were aged <5 years. Overall, 14.4% of NS specimens were influenza-positive by RIDT. RIDT overall sensitivity was 77.1% (95% CI 72.8-81.0%) and specificity was 94.9% (95% CI 94.0-95.7%) compared to rRT-PCR using NS specimens. RIDT sensitivity for influenza A virus compared to rRT-PCR using NS specimens was 71.8% (95% CI 66.7-76.4%) and was significantly higher than for influenza B which was 43.8% (95% CI 33.8-54.2%). PPV ranged from 30%-80% depending on background prevalence of influenza.
Although the variable seasonality of influenza in tropical Africa presents unique challenges, RIDTs may have a role in making influenza surveillance sustainable in more remote areas of Africa, where laboratory capacity is limited.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-016-2131-9</identifier><identifier>PMID: 28077093</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens ; Antigens, Viral - analysis ; Betainfluenzavirus - genetics ; Care and treatment ; Child ; Child, Preschool ; Chromatography ; Diagnosis ; Diagnostic tests ; Evaluation ; Female ; Health surveillance ; Hospitals ; Humans ; Immunoassay ; Infant ; Infections ; Influenza ; Influenza A virus - genetics ; Influenza, Human - diagnosis ; Influenza, Human - virology ; Informed consent ; Kenya ; Laboratories ; Male ; Middle Aged ; Nasal Mucosa - virology ; Nasopharynx - virology ; Oropharynx - virology ; Pneumonia ; Point-of-Care Testing ; Polymerase chain reaction ; Predictive Value of Tests ; Reagents ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Sentinel surveillance ; Technology application ; Viruses ; Young Adult</subject><ispartof>BMC infectious diseases, 2017-01, Vol.17 (1), p.60-60, Article 60</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-3d799e5d6ebdb669bfe57ab0c26bf8e4cfb125cacc7e14223abf29984453389c3</citedby><cites>FETCH-LOGICAL-c562t-3d799e5d6ebdb669bfe57ab0c26bf8e4cfb125cacc7e14223abf29984453389c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225564/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225564/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28077093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ndegwa, Linus K</creatorcontrib><creatorcontrib>Emukule, Gideon</creatorcontrib><creatorcontrib>Uyeki, Timothy M</creatorcontrib><creatorcontrib>Mailu, Eunice</creatorcontrib><creatorcontrib>Chaves, Sandra S</creatorcontrib><creatorcontrib>Widdowson, Marc-Alain</creatorcontrib><creatorcontrib>Lewa, Bandika V</creatorcontrib><creatorcontrib>Muiruri, Francis K</creatorcontrib><creatorcontrib>Omoth, Peter</creatorcontrib><creatorcontrib>Fields, Barry</creatorcontrib><creatorcontrib>Mott, Joshua A</creatorcontrib><title>Evaluation of the point-of-care Becton Dickinson Veritor™ Rapid influenza diagnostic test in Kenya, 2013-2014</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable.
Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the RIDT using NS specimens were evaluated against nasal swabs tested by real time reverse transcription polymerase chain reaction (rRT-PCR). The performance parameter results were expressed as 95% confidence intervals (CI) calculated using binomial exact methods, with P < 0.05 considered significant. Two-sample Z tests were used to test for differences in sample proportions. Analysis was performed using SAS software version 9.3.
From July 2013 to July 2014, 3,569 patients were recruited, of which 78.7% were aged <5 years. Overall, 14.4% of NS specimens were influenza-positive by RIDT. RIDT overall sensitivity was 77.1% (95% CI 72.8-81.0%) and specificity was 94.9% (95% CI 94.0-95.7%) compared to rRT-PCR using NS specimens. RIDT sensitivity for influenza A virus compared to rRT-PCR using NS specimens was 71.8% (95% CI 66.7-76.4%) and was significantly higher than for influenza B which was 43.8% (95% CI 33.8-54.2%). PPV ranged from 30%-80% depending on background prevalence of influenza.
Although the variable seasonality of influenza in tropical Africa presents unique challenges, RIDTs may have a role in making influenza surveillance sustainable in more remote areas of Africa, where laboratory capacity is limited.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Antigens, Viral - analysis</subject><subject>Betainfluenzavirus - genetics</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography</subject><subject>Diagnosis</subject><subject>Diagnostic tests</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health surveillance</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Infant</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A virus - genetics</subject><subject>Influenza, Human - diagnosis</subject><subject>Influenza, Human - virology</subject><subject>Informed consent</subject><subject>Kenya</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasal Mucosa - virology</subject><subject>Nasopharynx - virology</subject><subject>Oropharynx - virology</subject><subject>Pneumonia</subject><subject>Point-of-Care Testing</subject><subject>Polymerase chain reaction</subject><subject>Predictive Value of Tests</subject><subject>Reagents</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sensitivity and Specificity</subject><subject>Sentinel surveillance</subject><subject>Technology application</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkt9OFTEQxjdGIog-gDemiTeSWOyf3W17QwKISCQhQeW26Xanh-Ke9rjtEvHaJ_HRfBJ7chA5xgvTpJ10fvM1M_2q6hklu5TK9nWiTAqFCW0xo5xi9aDaorWgmHFeP7wXb1aPU7oihArJ1KNqk0kiBFF8q4pH12aYTPYxoOhQvgS0iD5kHB22ZgR0ADaX3BtvP_uQSnQBo89x_Pn9Bzo3C98jH9wwQfhmUO_NLMSUvUUZUi4Z9B7CjXmFGKEcl61-Um04MyR4entuV5_eHn08fIdPz45PDvdPsW1aljHvhVLQ9C10fde2qnPQCNMRy9rOSait6yhrrLFWAK0Z46ZzTClZ1w3nUlm-Xe2tdBdTN4feQsijGfRi9HMz3uhovF7PBH-pZ_FaN4w1TVsXgZe3AmP8MpVu9NwnC8NgAsQpaSobSYkiUhb0xV_oVZzGUNorVMsFoaRWf6iZGUCXocXyrl2K6v1aiPKBTPFC7f6DKquHubcxgPPlfq1gZ62gMBm-5pmZUtInH87_nz27WGfpirVjTGkEdzc7SvTSfXrlPl3cp5fu08sWn98f-l3Fb7vxX-uo0vc</recordid><startdate>20170111</startdate><enddate>20170111</enddate><creator>Ndegwa, Linus K</creator><creator>Emukule, Gideon</creator><creator>Uyeki, Timothy M</creator><creator>Mailu, Eunice</creator><creator>Chaves, Sandra S</creator><creator>Widdowson, Marc-Alain</creator><creator>Lewa, Bandika V</creator><creator>Muiruri, Francis K</creator><creator>Omoth, Peter</creator><creator>Fields, Barry</creator><creator>Mott, Joshua A</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170111</creationdate><title>Evaluation of the point-of-care Becton Dickinson Veritor™ Rapid influenza diagnostic test in Kenya, 2013-2014</title><author>Ndegwa, Linus K ; Emukule, Gideon ; Uyeki, Timothy M ; Mailu, Eunice ; Chaves, Sandra S ; Widdowson, Marc-Alain ; Lewa, Bandika V ; Muiruri, Francis K ; Omoth, Peter ; Fields, Barry ; Mott, Joshua A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-3d799e5d6ebdb669bfe57ab0c26bf8e4cfb125cacc7e14223abf29984453389c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Antigens, Viral - analysis</topic><topic>Betainfluenzavirus - genetics</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography</topic><topic>Diagnosis</topic><topic>Diagnostic tests</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health surveillance</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Infant</topic><topic>Infections</topic><topic>Influenza</topic><topic>Influenza A virus - genetics</topic><topic>Influenza, Human - diagnosis</topic><topic>Influenza, Human - virology</topic><topic>Informed consent</topic><topic>Kenya</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasal Mucosa - virology</topic><topic>Nasopharynx - virology</topic><topic>Oropharynx - virology</topic><topic>Pneumonia</topic><topic>Point-of-Care Testing</topic><topic>Polymerase chain reaction</topic><topic>Predictive Value of Tests</topic><topic>Reagents</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sensitivity and Specificity</topic><topic>Sentinel surveillance</topic><topic>Technology application</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndegwa, Linus K</creatorcontrib><creatorcontrib>Emukule, Gideon</creatorcontrib><creatorcontrib>Uyeki, Timothy M</creatorcontrib><creatorcontrib>Mailu, Eunice</creatorcontrib><creatorcontrib>Chaves, Sandra S</creatorcontrib><creatorcontrib>Widdowson, Marc-Alain</creatorcontrib><creatorcontrib>Lewa, Bandika V</creatorcontrib><creatorcontrib>Muiruri, Francis K</creatorcontrib><creatorcontrib>Omoth, Peter</creatorcontrib><creatorcontrib>Fields, Barry</creatorcontrib><creatorcontrib>Mott, Joshua A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndegwa, Linus K</au><au>Emukule, Gideon</au><au>Uyeki, Timothy M</au><au>Mailu, Eunice</au><au>Chaves, Sandra S</au><au>Widdowson, Marc-Alain</au><au>Lewa, Bandika V</au><au>Muiruri, Francis K</au><au>Omoth, Peter</au><au>Fields, Barry</au><au>Mott, Joshua A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the point-of-care Becton Dickinson Veritor™ Rapid influenza diagnostic test in Kenya, 2013-2014</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2017-01-11</date><risdate>2017</risdate><volume>17</volume><issue>1</issue><spage>60</spage><epage>60</epage><pages>60-60</pages><artnum>60</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>We evaluated the performance of the Becton Dickinson Veritor™ System Flu A + B rapid influenza diagnostic test (RIDT) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in Kenya, a tropical country where influenza seasonality is variable.
Nasal swab (NS) and nasopharyngeal (NP)/oropharyngeal (OP) swabs were collected from patients with influenza like illness and/or severe acute respiratory infection. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the RIDT using NS specimens were evaluated against nasal swabs tested by real time reverse transcription polymerase chain reaction (rRT-PCR). The performance parameter results were expressed as 95% confidence intervals (CI) calculated using binomial exact methods, with P < 0.05 considered significant. Two-sample Z tests were used to test for differences in sample proportions. Analysis was performed using SAS software version 9.3.
From July 2013 to July 2014, 3,569 patients were recruited, of which 78.7% were aged <5 years. Overall, 14.4% of NS specimens were influenza-positive by RIDT. RIDT overall sensitivity was 77.1% (95% CI 72.8-81.0%) and specificity was 94.9% (95% CI 94.0-95.7%) compared to rRT-PCR using NS specimens. RIDT sensitivity for influenza A virus compared to rRT-PCR using NS specimens was 71.8% (95% CI 66.7-76.4%) and was significantly higher than for influenza B which was 43.8% (95% CI 33.8-54.2%). PPV ranged from 30%-80% depending on background prevalence of influenza.
Although the variable seasonality of influenza in tropical Africa presents unique challenges, RIDTs may have a role in making influenza surveillance sustainable in more remote areas of Africa, where laboratory capacity is limited.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28077093</pmid><doi>10.1186/s12879-016-2131-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Antigens Antigens, Viral - analysis Betainfluenzavirus - genetics Care and treatment Child Child, Preschool Chromatography Diagnosis Diagnostic tests Evaluation Female Health surveillance Hospitals Humans Immunoassay Infant Infections Influenza Influenza A virus - genetics Influenza, Human - diagnosis Influenza, Human - virology Informed consent Kenya Laboratories Male Middle Aged Nasal Mucosa - virology Nasopharynx - virology Oropharynx - virology Pneumonia Point-of-Care Testing Polymerase chain reaction Predictive Value of Tests Reagents Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Sentinel surveillance Technology application Viruses Young Adult |
| title | Evaluation of the point-of-care Becton Dickinson Veritor™ Rapid influenza diagnostic test in Kenya, 2013-2014 |
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