Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine

One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvasc...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.40467-40467, Article 40467
Hauptverfasser:	Liu, Liqun, Yu, Jingyi, Li, Li, Zhang, Bao, Liu, Lingjuan, Wu, Chun-Hua, Jong, Ambrose, Mao, Ding-An, Huang, Sheng-He
Format:	Artikel
Sprache:	eng
Schlagworte:	14/34 14/63 631/378 64/60 692/4017 82/51 82/80 Acetylcholine receptors (nicotinic) Aconitine - analogs & derivatives Aconitine - pharmacology alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors alpha7 Nicotinic Acetylcholine Receptor - metabolism Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - pathology Amyloid - metabolism Amyloid beta-Peptides - metabolism Animal models Animals Biomarkers - metabolism Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - injuries Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Brain - pathology Cell Movement - drug effects Cellular Senescence - drug effects Cerebrospinal fluid Cognition Drug abuse Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Glycoprotein gp120 Glycoproteins HIV Envelope Protein gp120 - pharmacology HL-60 Cells Humanities and Social Sciences Humans Hydrolase Methamphetamine Methamphetamine - pharmacology Methyllycaconitine Mice, Inbred C57BL Microvasculature Monocytes - drug effects Monocytes - metabolism multidisciplinary Nicotine Nicotine - pharmacology Protein Transport - drug effects Receptor for Advanced Glycation End Products - metabolism S100 Proteins - metabolism Science Science (multidisciplinary) Tau protein Time Factors Ubiquitin Ubiquitin thiolesterase β-Amyloid
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