Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure

Polychlorinated biphenyls (PCBs) are organochlorine pollutants with a worldwide dissemination. We examined telomere length (TL) in peripheral blood cells of 207 individuals with a high body burden of PCBs due to occupational exposure in a transformer recycling company. Whereas TL in granulocytes was...

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Veröffentlicht in:	Archives of toxicology 2017-01, Vol.91 (1), p.289-300
Hauptverfasser:	Ziegler, Susanne, Schettgen, Thomas, Beier, Fabian, Wilop, Stefan, Quinete, Natalia, Esser, Andre, Masouleh, Behzad Kharabi, Ferreira, Monica S. V., Vankann, Lucia, Uciechowski, Peter, Rink, Lothar, Kraus, Thomas, Brümmendorf, Tim H., Ziegler, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Biotransformation Carcinogens, Environmental - analysis Carcinogens, Environmental - toxicity Cell Proliferation - drug effects Cells, Cultured Cohort Studies Drug Residues - analysis Environmental Health Female Gene Expression Regulation, Enzymologic - drug effects Germany Humans Immunologic Surveillance - drug effects Kinetics Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Male Molecular Toxicology Occupational Exposure - adverse effects Occupational hazards Occupational Medicine/Industrial Medicine PCB Pharmacology/Toxicology Polychlorinated biphenyls Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - metabolism Polychlorinated Biphenyls - toxicity Population Surveillance Recycling Telomerase Telomerase - antagonists & inhibitors Telomerase - blood Telomerase - metabolism Telomere Shortening - drug effects Toxicokinetics
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