ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis

Loss-of-function mutations in SWI/SNF chromatin-remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. Here, we reveal that ACTL6A, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, is frequently co-amplified and...

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Veröffentlicht in:	Cancer cell 2017-01, Vol.31 (1), p.35-49
Hauptverfasser:	Saladi, Srinivas Vinod, Ross, Kenneth, Karaayvaz, Mihriban, Tata, Purushothama R., Mou, Hongmei, Rajagopal, Jayaraj, Ramaswamy, Sridhar, Ellisen, Leif W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - physiology ACTL6A Adaptor Proteins, Signal Transducing - physiology Animals Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - mortality Cell Line, Tumor Cell Proliferation chromatin remodeling Chromosomal Proteins, Non-Histone - physiology DNA-Binding Proteins - physiology Head and Neck Neoplasms - etiology Head and Neck Neoplasms - mortality hippo pathway HNSCC Humans Intracellular Signaling Peptides and Proteins - physiology Membrane Proteins - physiology Mice p63 Phosphoproteins - physiology Prognosis Protein-Serine-Threonine Kinases - physiology squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck SWI/SNF (BAF) complex Transcription Factors Transcriptome YAP1
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