Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

Distinguishing true Ag-stimulated lymphocytes from bystanders activated by the inflammatory milieu has been difficult. Nur77 is an immediate early gene whose expression is rapidly upregulated by TCR signaling in murine T cells and human thymocytes. Nur77-GFP transgenes serve as specific TCR and BCR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2017-01, Vol.198 (2), p.657-668
Hauptverfasser:	Ashouri, Judith F, Weiss, Arthur
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals B-cell receptor B-Lymphocytes - immunology Blotting, Western CD69 antigen Cell activation Flow Cytometry Fluorescent Antibody Technique Humans Immunofluorescence Inflammation Lymphocyte Activation - immunology Lymphocytes Lymphocytes B Lymphocytes T Mice Mice, Inbred C57BL Nuclear Receptor Subfamily 4, Group A, Member 1 - immunology Nur77 protein Protein expression Proteins Receptors, Antigen - immunology T cell receptors T-Lymphocytes - immunology Thymocytes Transgenes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!