Over-expression of Toll-like receptor 2 up-regulates heme oxygenase-1 expression and decreases oxidative injury in dairy goats

Background： Mastitis, an infection caused by Gram-positive bacteria, produces udder inflammation and oxidative injury in milk-producing mammals. Toll-like receptor 2（TLR2） is important for host recognition of invading Grampositive microbes. Over-expression of TLR2 in transgenic dairy goats is a usef...

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Veröffentlicht in:	Journal of Animal Science and Biotechnology 2017-01, Vol.8 (2), p.351-360, Article 3
Hauptverfasser:	Deng, Shoulong, Yu, Kun, Jiang, Wuqi, Li, Yan, Wang, Shuotian, Deng, Zhuo, Yao, Yuchang, Zhang, Baolu, Liu, Guoshi, Liu, Yixun, Lian, Zhengxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria chemical elements dairy goats ears Enzymes Gene expression gene overexpression genes Goats Gram-positive bacteria Heme heme oxygenase (biliverdin-producing) inflammation Kinases lipids mastitis messenger RNA Oxidation Oxidative stress phosphatidylinositol 3-kinase Physiological aspects Proteins signal transduction Staphylococcus infections TLR2 Toll-like receptor 2 Toll样受体 transcription (genetics) transcription factor NF-kappa B Transcription factors transgenic animals Tumor necrosis factor-TNF udders 乳山羊核转录因子κB 氧化损伤磷脂酰肌醇3-激酶血红素氧合酶-1 过度表达革兰氏阳性菌
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