HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals

The hyperpolarization-activated cyclic nucleotide-gated (HCN1) channels are predominantly located in pyramidal cell dendrites within the cortex. Recent evidence suggests these channels also exist pre-synaptically in a subset of synaptic terminals within the mature entorhinal cortex (EC). Inhibition...

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Veröffentlicht in:	Scientific reports 2017-01, Vol.7 (1), p.40257-40257, Article 40257
Hauptverfasser:	Huang, Zhuo, Li, Gengyu, Aguado, Carolina, Lujan, Rafael, Shah, Mala M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/34 14/69 631/378 631/443 9/74 Action potential Animals Cortex (entorhinal) Dendrites Dendrites - physiology Electrophysiology Exocytosis Female Forebrain Humanities and Social Sciences Hyperpolarization Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology Integration Ion channels (cyclic nucleotide-gated) Male Mice, Knockout multidisciplinary Neurotransmitter release Pharmacology Potassium Channels - genetics Potassium Channels - physiology Presynaptic Terminals - physiology Prosencephalon - physiology Pyramidal cells Pyramidal Cells - physiology Rodents Science Synaptic plasticity Synaptic Potentials Synaptic strength Synaptic vesicles
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