Stretching Impacts Inflammation Resolution in Connective Tissue
Acute inflammation is accompanied from its outset by the release of specialized pro‐resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching fo...
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| Veröffentlicht in: | Journal of cellular physiology 2016-07, Vol.231 (7), p.1621-1627 |
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| container_title | Journal of cellular physiology |
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| creator | Berrueta, Lisbeth Muskaj, Igla Olenich, Sara Butler, Taylor Badger, Gary J. Colas, Romain A. Spite, Matthew Serhan, Charles N. Langevin, Helene M. |
| description | Acute inflammation is accompanied from its outset by the release of specialized pro‐resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro‐resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation‐regulation mechanisms within connective tissue. J. Cell. Physiol. 231: 1621–1627, 2016. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jcp.25263 |
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We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro‐resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation‐regulation mechanisms within connective tissue. J. Cell. Physiol. 231: 1621–1627, 2016. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.25263</identifier><identifier>PMID: 26588184</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Carrageenan ; Carrageenan - toxicity ; Connective Tissue - metabolism ; Connective Tissue - pathology ; Connective tissues ; Docosahexaenoic Acids - metabolism ; Inflammation ; Inflammation - metabolism ; Inflammation - pathology ; Inflammation - therapy ; Injection ; Lesions ; Leukocyte migration ; Leukocytes (neutrophilic) ; Macrophages - metabolism ; Macrophages - pathology ; Mechanical Phenomena ; Muscle Stretching Exercises ; Neutrophils - metabolism ; Pain ; Pain - chemically induced ; Pain - prevention & control ; Pain Management ; Phagocytosis - genetics ; Rats ; Stretching ; Tissues</subject><ispartof>Journal of cellular physiology, 2016-07, Vol.231 (7), p.1621-1627</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5413-d1627b77b07ec444ac1fa8be6f3cc36ed76216ea3d0e5984c3a0c35acde42863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.25263$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.25263$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26588184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berrueta, Lisbeth</creatorcontrib><creatorcontrib>Muskaj, Igla</creatorcontrib><creatorcontrib>Olenich, Sara</creatorcontrib><creatorcontrib>Butler, Taylor</creatorcontrib><creatorcontrib>Badger, Gary J.</creatorcontrib><creatorcontrib>Colas, Romain A.</creatorcontrib><creatorcontrib>Spite, Matthew</creatorcontrib><creatorcontrib>Serhan, Charles N.</creatorcontrib><creatorcontrib>Langevin, Helene M.</creatorcontrib><title>Stretching Impacts Inflammation Resolution in Connective Tissue</title><title>Journal of cellular physiology</title><addtitle>J. Cell. Physiol</addtitle><description>Acute inflammation is accompanied from its outset by the release of specialized pro‐resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro‐resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation‐regulation mechanisms within connective tissue. J. Cell. Physiol. 231: 1621–1627, 2016. © 2015 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>Carrageenan</subject><subject>Carrageenan - toxicity</subject><subject>Connective Tissue - metabolism</subject><subject>Connective Tissue - pathology</subject><subject>Connective tissues</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inflammation - therapy</subject><subject>Injection</subject><subject>Lesions</subject><subject>Leukocyte migration</subject><subject>Leukocytes (neutrophilic)</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - pathology</subject><subject>Mechanical Phenomena</subject><subject>Muscle Stretching Exercises</subject><subject>Neutrophils - metabolism</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - prevention & control</subject><subject>Pain Management</subject><subject>Phagocytosis - genetics</subject><subject>Rats</subject><subject>Stretching</subject><subject>Tissues</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UclOwzAQtRAISuHAD6BIXLgEvDu5gKCCUsQmqMTRcp0puCROiROWvye0UAEHTjPSW-aNHkJbBO8RjOn-xE73qKCSLaEOwamKuRR0GXVajMSp4GQNrYcwwRinKWOraI1KkSQk4R10eFdXUNtH5x-iQTE1tg7RwI9zUxSmdqWPbiGUeTNbnY96pfdga_cC0dCF0MAGWhmbPMDm1-yi4enJsHcWX1z3B72ji9i251mcEUnVSKkRVmA558aSsUlGIMfMWiYhU5ISCYZlGESacMsMtkwYmwGniWRddDC3nTajAjILvq5MrqeVK0z1rkvj9G_Eu0f9UL5oQSmVmLYGu18GVfncQKh14YKFPDceyiZoopQgivA2bBft_KFOyqby7XeapIQlRPFU_MtSinOcfBbSRds_cy8CfxfQEvbnhFeXw_sCJ1h_NqvbZvWsWX3eu5ktrSKeK1yo4W2hMNWTloopoe-v-vqY9W_Oji-pvmMf4K-kUA</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Berrueta, Lisbeth</creator><creator>Muskaj, Igla</creator><creator>Olenich, Sara</creator><creator>Butler, Taylor</creator><creator>Badger, Gary J.</creator><creator>Colas, Romain A.</creator><creator>Spite, Matthew</creator><creator>Serhan, Charles N.</creator><creator>Langevin, Helene M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201607</creationdate><title>Stretching Impacts Inflammation Resolution in Connective Tissue</title><author>Berrueta, Lisbeth ; 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Cell. Physiol</addtitle><date>2016-07</date><risdate>2016</risdate><volume>231</volume><issue>7</issue><spage>1621</spage><epage>1627</epage><pages>1621-1627</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Acute inflammation is accompanied from its outset by the release of specialized pro‐resolving mediators (SPMs), including resolvins, that orchestrate the resolution of local inflammation. We showed earlier that, in rats with subcutaneous inflammation of the back induced by carrageenan, stretching for 10 min twice daily reduced inflammation and improved pain, 2 weeks after carrageenan injection. In this study, we hypothesized that stretching of connective tissue activates local pro‐resolving mechanisms within the tissue in the acute phase of inflammation. In rats injected with carrageenan and randomized to stretch versus no stretch for 48 h, stretching reduced inflammatory lesion thickness and neutrophil count, and increased resolvin (RvD1) concentrations within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect of stretching. In ex vivo experiments, stretching of connective tissue reduced the migration of neutrophils and increased tissue RvD1 concentration. These results demonstrate a direct mechanical impact of stretching on inflammation‐regulation mechanisms within connective tissue. J. Cell. Physiol. 231: 1621–1627, 2016. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26588184</pmid><doi>10.1002/jcp.25263</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Carrageenan Carrageenan - toxicity Connective Tissue - metabolism Connective Tissue - pathology Connective tissues Docosahexaenoic Acids - metabolism Inflammation Inflammation - metabolism Inflammation - pathology Inflammation - therapy Injection Lesions Leukocyte migration Leukocytes (neutrophilic) Macrophages - metabolism Macrophages - pathology Mechanical Phenomena Muscle Stretching Exercises Neutrophils - metabolism Pain Pain - chemically induced Pain - prevention & control Pain Management Phagocytosis - genetics Rats Stretching Tissues |
| title | Stretching Impacts Inflammation Resolution in Connective Tissue |
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