Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation

Alisol B 23-acetate （AB23A） is a natural triterpenoid isolated from the traditional Chinese medicine rhizoma alismatis, which exhibits a number of pharmacological activities, including anti-hepatitis virus, anti-cancer and antibacterial effects. In this study we examined whether AB23A protected agai...

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Veröffentlicht in:	Acta pharmacologica Sinica 2017-01, Vol.38 (1), p.69-79
Hauptverfasser:	Meng, Qiang, Duan, Xing-ping, Wang, Chang-yuan, Liu, Zhi-hao, Sun, Peng-yuan, Huo, Xiao-kui, Sun, Hui-jun, Peng, Jin-yong, Liu, Ke-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Chenodeoxycholic Acid - pharmacology Cholestenones - antagonists & inhibitors Cholestenones - pharmacology Choline Deficiency Dose-Response Relationship, Drug Fibrosis - pathology Gene Expression - drug effects Hepatocytes - metabolism Immunology Internal Medicine Lipid Metabolism - drug effects Lipogenesis - drug effects Liver - enzymology Liver - metabolism Liver - pathology Male Medical Microbiology Methionine - deficiency Mice Non-alcoholic Fatty Liver Disease - prevention & control Original original-article Pharmacology/Toxicology Pregnenediones - pharmacology Primary Cell Culture Protective Agents - pharmacology Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Vaccine 受体拮抗剂法尼醇激活作用肝炎病毒脂肪合成荧光定量PCR 酒精性醋酸
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