Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium

Aberrant Wnt signaling within breast cancer is associated with poor prognosis, but regulation of this pathway in breast tissue remains poorly understood and the consequences of immediate or long-term dysregulation remain elusive. The exact contribution of the Wnt-regulating proteins adenomatous poly...

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Veröffentlicht in:	Oncogene 2017-03, Vol.36 (13), p.1793-1803
Hauptverfasser:	Daly, C S, Shaw, P, Ordonez, L D, Williams, G T, Quist, J, Grigoriadis, A, Van Es, J H, Clevers, H, Clarke, A R, Reed, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/1 631/208/68 631/67/1347 631/67/68 64/60 82/51 Adenomatous polyposis coli Adenomatous Polyposis Coli Protein - genetics Adenomatous Polyposis Coli Protein - metabolism Analysis Animals Apoptosis beta Catenin - genetics beta Catenin - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinogenesis Carcinogenesis - genetics Carcinogenesis - metabolism Cell Biology Cell division Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism DNA Copy Number Variations Epithelium Epithelium - metabolism Epithelium - pathology Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic disorders Genetic regulation Homeostasis Homeostasis - genetics Human Genetics Humans Hyperplasia Internal Medicine Lactation - genetics Mammary gland Mammary Neoplasms, Animal Medical prognosis Medicine Medicine & Public Health Mice Mice, Transgenic Oncology Original original-article Phenotypes Physiological aspects Polyposis coli Prognosis Proteins Signal transduction Tumorigenesis Tumors Wnt protein β-Catenin
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