Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs
Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there are no studies of these markers in canine obesity. This study was designed to evaluate the...
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| Veröffentlicht in: | BMC veterinary research 2017-01, Vol.13 (1), p.13-13, Article 13 |
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| creator | Barić Rafaj, R Kuleš, J Marinculić, A Tvarijonaviciute, A Ceron, J Mihaljević, Ž Tumpa, A Mrljak, V |
| description | Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there are no studies of these markers in canine obesity. This study was designed to evaluate the effect of naturally gained weight excess and obesity on inflammatory, hemostatic and endothelial biomarkers in dogs. A total of 37 overweight and obese dogs were compared with 28 normal weight dogs.
Overweight and obese dogs had significantly elevated concentrations of serum interleukin-6 (IL-6) and C-reactive protein (hsCRP). Number of platelets, activity of factor X and factor VII were significantly higher, while activated partial thromboplastine time (aPTT) and soluble plasminogen activator receptor (suPAR) were significantly decreased. Statistical analysis of high mobility group box - 1 protein (HMGB-1), soluble intercellular adhesive molecule -1 (sICAM-1) and plasminogen activator inhibitor type 1 (PAI-1) concentrations did not show significant differences between the total overweight and obese group and the normal weight group of dogs.
Analytical changes in the dogs in our study reflects that weight excess in dogs can be associated with a chronic low degree of inflammation and a hypercoagulable state, where primary and secondary hemostasis are both affected. However obesity is not associated with impairment of endothelial function in dogs. |
| doi_str_mv | 10.1186/s12917-016-0929-8 |
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Overweight and obese dogs had significantly elevated concentrations of serum interleukin-6 (IL-6) and C-reactive protein (hsCRP). Number of platelets, activity of factor X and factor VII were significantly higher, while activated partial thromboplastine time (aPTT) and soluble plasminogen activator receptor (suPAR) were significantly decreased. Statistical analysis of high mobility group box - 1 protein (HMGB-1), soluble intercellular adhesive molecule -1 (sICAM-1) and plasminogen activator inhibitor type 1 (PAI-1) concentrations did not show significant differences between the total overweight and obese group and the normal weight group of dogs.
Analytical changes in the dogs in our study reflects that weight excess in dogs can be associated with a chronic low degree of inflammation and a hypercoagulable state, where primary and secondary hemostasis are both affected. However obesity is not associated with impairment of endothelial function in dogs.</description><identifier>ISSN: 1746-6148</identifier><identifier>EISSN: 1746-6148</identifier><identifier>DOI: 10.1186/s12917-016-0929-8</identifier><identifier>PMID: 28061787</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Biomarkers ; Blood Coagulation ; C-reactive protein ; Care and treatment ; Comparative analysis ; Dog Diseases - blood ; Dogs ; Endothelium ; Endothelium, Vascular - physiology ; Female ; Health aspects ; Hemostatics - metabolism ; Homeostasis ; Inflammation - blood ; Male ; Obesity ; Overweight - blood ; Overweight - metabolism ; Overweight - veterinary ; Prospective Studies</subject><ispartof>BMC veterinary research, 2017-01, Vol.13 (1), p.13-13, Article 13</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-4cf758c4ee643a6f257bbdd0b4d1302eb97479a50a87663e0784b1fe41e2978b3</citedby><cites>FETCH-LOGICAL-c494t-4cf758c4ee643a6f257bbdd0b4d1302eb97479a50a87663e0784b1fe41e2978b3</cites><orcidid>0000-0002-4945-4690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219720/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219720/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28061787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barić Rafaj, R</creatorcontrib><creatorcontrib>Kuleš, J</creatorcontrib><creatorcontrib>Marinculić, A</creatorcontrib><creatorcontrib>Tvarijonaviciute, A</creatorcontrib><creatorcontrib>Ceron, J</creatorcontrib><creatorcontrib>Mihaljević, Ž</creatorcontrib><creatorcontrib>Tumpa, A</creatorcontrib><creatorcontrib>Mrljak, V</creatorcontrib><title>Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs</title><title>BMC veterinary research</title><addtitle>BMC Vet Res</addtitle><description>Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there are no studies of these markers in canine obesity. This study was designed to evaluate the effect of naturally gained weight excess and obesity on inflammatory, hemostatic and endothelial biomarkers in dogs. A total of 37 overweight and obese dogs were compared with 28 normal weight dogs.
Overweight and obese dogs had significantly elevated concentrations of serum interleukin-6 (IL-6) and C-reactive protein (hsCRP). Number of platelets, activity of factor X and factor VII were significantly higher, while activated partial thromboplastine time (aPTT) and soluble plasminogen activator receptor (suPAR) were significantly decreased. Statistical analysis of high mobility group box - 1 protein (HMGB-1), soluble intercellular adhesive molecule -1 (sICAM-1) and plasminogen activator inhibitor type 1 (PAI-1) concentrations did not show significant differences between the total overweight and obese group and the normal weight group of dogs.
Analytical changes in the dogs in our study reflects that weight excess in dogs can be associated with a chronic low degree of inflammation and a hypercoagulable state, where primary and secondary hemostasis are both affected. However obesity is not associated with impairment of endothelial function in dogs.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Blood Coagulation</subject><subject>C-reactive protein</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Dog Diseases - blood</subject><subject>Dogs</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hemostatics - metabolism</subject><subject>Homeostasis</subject><subject>Inflammation - blood</subject><subject>Male</subject><subject>Obesity</subject><subject>Overweight - blood</subject><subject>Overweight - metabolism</subject><subject>Overweight - veterinary</subject><subject>Prospective Studies</subject><issn>1746-6148</issn><issn>1746-6148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1vFSEUJUZja_UHuDGTuHEzFRiGj41J09hq0kQX7ZowzJ33qAxUYJ55_15eX-1XDAu4cM65nJuD0HuCjwmR_HMmVBHRYsJbrKhq5Qt0SATjLSdMvnx0PkBvcr7GmDEl-Gt0QCXmREhxiOaf3uTZNLNJvyDlJk6NC5M382yKi6ExYWzWMMdcam1vSwhjLGvwzvjG2OI2rmwrqQmmLMl4v23iBtIfcKt1uSXEATI0Y1zlt-jVZHyGd3f7Ebo6-3p5-q29-HH-_fTkorVMsdIyO4leWgbAWWf4RHsxDOOIBzaSDlMYlGBCmR4bKTjvAAvJBjIBI0CVkEN3hL7sdW-WYYbRQij1Z_omuepzq6Nx-ulLcGu9ihvdU6IExVXg051Air8XyEXPLlvw3gSIS9ZE9rxXrOOkQj8-g17HJYVqr6I4E5JKyR5QK-NB1xHH2tfuRPUJE1wwrJSqqOP_oOoaYXY2BphcvX9CIHuCTTHnBNO9R4L1LiN6nxFdM6J3GdGycj48Hs49418our9m27hA</recordid><startdate>20170106</startdate><enddate>20170106</enddate><creator>Barić Rafaj, R</creator><creator>Kuleš, J</creator><creator>Marinculić, A</creator><creator>Tvarijonaviciute, A</creator><creator>Ceron, J</creator><creator>Mihaljević, Ž</creator><creator>Tumpa, A</creator><creator>Mrljak, V</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4945-4690</orcidid></search><sort><creationdate>20170106</creationdate><title>Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs</title><author>Barić Rafaj, R ; Kuleš, J ; Marinculić, A ; Tvarijonaviciute, A ; Ceron, J ; Mihaljević, Ž ; Tumpa, A ; Mrljak, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-4cf758c4ee643a6f257bbdd0b4d1302eb97479a50a87663e0784b1fe41e2978b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Blood Coagulation</topic><topic>C-reactive protein</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Dog Diseases - blood</topic><topic>Dogs</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hemostatics - metabolism</topic><topic>Homeostasis</topic><topic>Inflammation - blood</topic><topic>Male</topic><topic>Obesity</topic><topic>Overweight - blood</topic><topic>Overweight - metabolism</topic><topic>Overweight - veterinary</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barić Rafaj, R</creatorcontrib><creatorcontrib>Kuleš, J</creatorcontrib><creatorcontrib>Marinculić, A</creatorcontrib><creatorcontrib>Tvarijonaviciute, A</creatorcontrib><creatorcontrib>Ceron, J</creatorcontrib><creatorcontrib>Mihaljević, Ž</creatorcontrib><creatorcontrib>Tumpa, A</creatorcontrib><creatorcontrib>Mrljak, V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barić Rafaj, R</au><au>Kuleš, J</au><au>Marinculić, A</au><au>Tvarijonaviciute, A</au><au>Ceron, J</au><au>Mihaljević, Ž</au><au>Tumpa, A</au><au>Mrljak, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs</atitle><jtitle>BMC veterinary research</jtitle><addtitle>BMC Vet Res</addtitle><date>2017-01-06</date><risdate>2017</risdate><volume>13</volume><issue>1</issue><spage>13</spage><epage>13</epage><pages>13-13</pages><artnum>13</artnum><issn>1746-6148</issn><eissn>1746-6148</eissn><abstract>Obesity is one of the most prevalent health problems in the canine population. While haemostatic parameters and markers of endothelial function have been evaluated in various disease conditions in dogs, there are no studies of these markers in canine obesity. This study was designed to evaluate the effect of naturally gained weight excess and obesity on inflammatory, hemostatic and endothelial biomarkers in dogs. A total of 37 overweight and obese dogs were compared with 28 normal weight dogs.
Overweight and obese dogs had significantly elevated concentrations of serum interleukin-6 (IL-6) and C-reactive protein (hsCRP). Number of platelets, activity of factor X and factor VII were significantly higher, while activated partial thromboplastine time (aPTT) and soluble plasminogen activator receptor (suPAR) were significantly decreased. Statistical analysis of high mobility group box - 1 protein (HMGB-1), soluble intercellular adhesive molecule -1 (sICAM-1) and plasminogen activator inhibitor type 1 (PAI-1) concentrations did not show significant differences between the total overweight and obese group and the normal weight group of dogs.
Analytical changes in the dogs in our study reflects that weight excess in dogs can be associated with a chronic low degree of inflammation and a hypercoagulable state, where primary and secondary hemostasis are both affected. However obesity is not associated with impairment of endothelial function in dogs.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28061787</pmid><doi>10.1186/s12917-016-0929-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4945-4690</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biomarkers Blood Coagulation C-reactive protein Care and treatment Comparative analysis Dog Diseases - blood Dogs Endothelium Endothelium, Vascular - physiology Female Health aspects Hemostatics - metabolism Homeostasis Inflammation - blood Male Obesity Overweight - blood Overweight - metabolism Overweight - veterinary Prospective Studies |
| title | Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs |
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