MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer
Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. The PTC pati...
Gespeichert in:
| Veröffentlicht in: | World journal of surgical oncology 2017-01, Vol.15 (1), p.11-11, Article 11 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | 1 |
| container_start_page | 11 |
| container_title | World journal of surgical oncology |
| container_volume | 15 |
| creator | Dai, Lei Wang, Yaozong Chen, Liangliang Zheng, Jueru Li, Jianjun Wu, Xianjiang |
| description | Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear.
The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis.
A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P |
| doi_str_mv | 10.1186/s12957-016-1086-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5219708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476741011</galeid><sourcerecordid>A476741011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c525t-2b1ef2f444b4ac854c3784adee2f0cee08c4c66af2209fc6b3c64fbab28300353</originalsourceid><addsrcrecordid>eNptkl1rFDEUhgdR7If-AG8kIEgvnJqTySSZm0IpfkFFkHodMtmT3dTZZExmhO2vN-vWuiuSi4Sc531zTnir6gXQcwAl3mZgXStrCqIGqkR996g6Bi5lLRV0j_fOR9VJzreUsqZpm6fVEVNUFAN1XN189l9rxuANMWSME4bJm4GMKS5DzJO3pPdxbdJ3TMTFRBLaOSUMFokPZDSjHwaTNmRabVL0C2JNKaVn1RNnhozP7_fT6tv7dzdXH-vrLx8-XV1e17Zl7VSzHtAxxznvubGq5baRipsFInPUIlJluRXCOMZo56zoGyu4603PVENpmeS0utj5jnO_xoUt3Scz6DH50vJGR-P1YSX4lV7Gn7pl0EmqisHZvUGKP2bMk177bLHMFDDOWYNqRdvxRsmCvvoHvY1zCmW83xRI3oL6Sy3NgNoHF8u7dmuqL7kUkgMFKNT5f6iyFrj2NgZ0vtwfCF7vCVZohmmV4zBPPoZ8CMIOtCnmnNA9fAZQvc2M3mVGl8zobWb0XdG83P_FB8WfkDS_AJyfu6g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1856174518</pqid></control><display><type>article</type><title>MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><creator>Dai, Lei ; Wang, Yaozong ; Chen, Liangliang ; Zheng, Jueru ; Li, Jianjun ; Wu, Xianjiang</creator><creatorcontrib>Dai, Lei ; Wang, Yaozong ; Chen, Liangliang ; Zheng, Jueru ; Li, Jianjun ; Wu, Xianjiang</creatorcontrib><description>Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear.
The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis.
A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14-1.95, P = 0.007) by multiple Cox proportional hazard analysis.
This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/s12957-016-1086-z</identifier><identifier>PMID: 28061868</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Analysis ; Biological markers ; Biomarkers, Tumor - genetics ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; Child ; Female ; Follow-Up Studies ; Gene expression ; Genetic aspects ; Humans ; Lymphatic Metastasis ; Male ; MicroRNA ; MicroRNAs - genetics ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Real-Time Polymerase Chain Reaction ; Recurrence (Disease) ; Thyroid cancer ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Young Adult</subject><ispartof>World journal of surgical oncology, 2017-01, Vol.15 (1), p.11-11, Article 11</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-2b1ef2f444b4ac854c3784adee2f0cee08c4c66af2209fc6b3c64fbab28300353</citedby><cites>FETCH-LOGICAL-c525t-2b1ef2f444b4ac854c3784adee2f0cee08c4c66af2209fc6b3c64fbab28300353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28061868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Lei</creatorcontrib><creatorcontrib>Wang, Yaozong</creatorcontrib><creatorcontrib>Chen, Liangliang</creatorcontrib><creatorcontrib>Zheng, Jueru</creatorcontrib><creatorcontrib>Li, Jianjun</creatorcontrib><creatorcontrib>Wu, Xianjiang</creatorcontrib><title>MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear.
The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis.
A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14-1.95, P = 0.007) by multiple Cox proportional hazard analysis.
This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Child</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Prognosis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Recurrence (Disease)</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Young Adult</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkl1rFDEUhgdR7If-AG8kIEgvnJqTySSZm0IpfkFFkHodMtmT3dTZZExmhO2vN-vWuiuSi4Sc531zTnir6gXQcwAl3mZgXStrCqIGqkR996g6Bi5lLRV0j_fOR9VJzreUsqZpm6fVEVNUFAN1XN189l9rxuANMWSME4bJm4GMKS5DzJO3pPdxbdJ3TMTFRBLaOSUMFokPZDSjHwaTNmRabVL0C2JNKaVn1RNnhozP7_fT6tv7dzdXH-vrLx8-XV1e17Zl7VSzHtAxxznvubGq5baRipsFInPUIlJluRXCOMZo56zoGyu4603PVENpmeS0utj5jnO_xoUt3Scz6DH50vJGR-P1YSX4lV7Gn7pl0EmqisHZvUGKP2bMk177bLHMFDDOWYNqRdvxRsmCvvoHvY1zCmW83xRI3oL6Sy3NgNoHF8u7dmuqL7kUkgMFKNT5f6iyFrj2NgZ0vtwfCF7vCVZohmmV4zBPPoZ8CMIOtCnmnNA9fAZQvc2M3mVGl8zobWb0XdG83P_FB8WfkDS_AJyfu6g</recordid><startdate>20170107</startdate><enddate>20170107</enddate><creator>Dai, Lei</creator><creator>Wang, Yaozong</creator><creator>Chen, Liangliang</creator><creator>Zheng, Jueru</creator><creator>Li, Jianjun</creator><creator>Wu, Xianjiang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170107</creationdate><title>MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer</title><author>Dai, Lei ; Wang, Yaozong ; Chen, Liangliang ; Zheng, Jueru ; Li, Jianjun ; Wu, Xianjiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-2b1ef2f444b4ac854c3784adee2f0cee08c4c66af2209fc6b3c64fbab28300353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Biological markers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Child</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Prognosis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Recurrence (Disease)</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Lei</creatorcontrib><creatorcontrib>Wang, Yaozong</creatorcontrib><creatorcontrib>Chen, Liangliang</creatorcontrib><creatorcontrib>Zheng, Jueru</creatorcontrib><creatorcontrib>Li, Jianjun</creatorcontrib><creatorcontrib>Wu, Xianjiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Lei</au><au>Wang, Yaozong</au><au>Chen, Liangliang</au><au>Zheng, Jueru</au><au>Li, Jianjun</au><au>Wu, Xianjiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2017-01-07</date><risdate>2017</risdate><volume>15</volume><issue>1</issue><spage>11</spage><epage>11</epage><pages>11-11</pages><artnum>11</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear.
The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study. The clinical and pathological characteristics of each patient were recorded in detail. The selected miRNA expressions were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Potential predictive factors for cancer recurrence were evaluated by univariate and multivariate Cox proportional hazard analysis.
A total of 78 patients were enrolled with 49 females at a mean age of 45.8 years. Enrolled patients were divided into two groups: nonrecurrent group (n = 54) and recurrent group (n = 24). The results from the univariate Cox proportional hazard analysis revealed that primary tumor size, TNM stage, extrathyroid extension, miR-221, and miR-222 expressions were significantly associated with PTC recurrence (P < 0.05). The tissue expression of miR-221 was the only independent risk factor for PTC recurrence (HR 1.41; 95%CI 1.14-1.95, P = 0.007) by multiple Cox proportional hazard analysis.
This study identified the potential role of miR-221 as a prognostic biomarker for the recurrence in PTC.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28061868</pmid><doi>10.1186/s12957-016-1086-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-7819 |
| ispartof | World journal of surgical oncology, 2017-01, Vol.15 (1), p.11-11, Article 11 |
| issn | 1477-7819 1477-7819 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5219708 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Adolescent Adult Analysis Biological markers Biomarkers, Tumor - genetics Carcinoma, Papillary - genetics Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery Child Female Follow-Up Studies Gene expression Genetic aspects Humans Lymphatic Metastasis Male MicroRNA MicroRNAs - genetics Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Oligonucleotide Array Sequence Analysis Prognosis Real-Time Polymerase Chain Reaction Recurrence (Disease) Thyroid cancer Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Young Adult |
| title | MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T06%3A27%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MiR-221,%20a%20potential%20prognostic%20biomarker%20for%20recurrence%20in%20papillary%20thyroid%20cancer&rft.jtitle=World%20journal%20of%20surgical%20oncology&rft.au=Dai,%20Lei&rft.date=2017-01-07&rft.volume=15&rft.issue=1&rft.spage=11&rft.epage=11&rft.pages=11-11&rft.artnum=11&rft.issn=1477-7819&rft.eissn=1477-7819&rft_id=info:doi/10.1186/s12957-016-1086-z&rft_dat=%3Cgale_pubme%3EA476741011%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1856174518&rft_id=info:pmid/28061868&rft_galeid=A476741011&rfr_iscdi=true |