A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance

Androgen deprivation therapy is the most effective treatment for advanced prostate cancer, but almost all cancer eventually becomes castration resistant, and the underlying mechanisms are largely unknown. Here, we show that an intrinsic constitutively activated feedforward signaling circuit composed...

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Veröffentlicht in:	Molecular cell 2017-01, Vol.65 (1), p.154-167
Hauptverfasser:	Jeong, Ji-Hak, Park, Sun-Jin, Dickinson, Shohreh Iravani, Luo, Jun-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced prostate cancer Androgen Antagonists - pharmacology androgen deprivation therapy Animals Antineoplastic Agents, Hormonal - pharmacology Calcineurin - genetics Calcineurin - metabolism castration-resistance castration-resistant prostate cancer Cell Line, Tumor Cell Proliferation constitutively activated inflammatory signaling Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Genes, myc Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Inflammation - genetics Inflammation - metabolism Inflammation - pathology Male Meis2 Mice, Transgenic MicroRNAs - genetics MicroRNAs - metabolism miR-196b-3p Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology NF-KappaB Inhibitor alpha - genetics NF-KappaB Inhibitor alpha - metabolism NF-κB Phenotype PPP3CC Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology RNA Interference Signal Transduction stem cell transcription factors Time Factors Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Burden Tumor Cells, Cultured tumorigenicity
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