The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW

GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC50 values of 220 μM and 320 μM, respectively), as well a...

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Veröffentlicht in:	Neurochemistry international 2017-01, Vol.102, p.105-113
Hauptverfasser:	Nøhr, Anne Cathrine, Shehata, Mohamed A., Hauser, Alexander S., Isberg, Vignir, Mokrosinski, Jacek, Andersen, Kirsten B., Farooqi, I. Sadaf, Pedersen, Daniel Sejer, Gloriam, David E., Bräuner-Osborne, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone (ACTH) Adrenocorticotropic Hormone - metabolism alpha-MSH - metabolism Amino Acid Motifs Animals beta-MSH - metabolism CHO Cells Cricetulus GPR139 Melanocyte stimulating hormone (MSH) Melanocyte-Stimulating Hormones - metabolism Melanocytes - metabolism Nerve Tissue Proteins - metabolism Orphan GPCR Peptide receptor Pro-opiomelanocortin (POMC) Pro-Opiomelanocortin - metabolism Receptor, Melanocortin, Type 4 - metabolism Receptors, G-Protein-Coupled - metabolism
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