Anti‐inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization

Summary Infliximab (IFX) has been used repeatedly in mouse preclinical models with associated claims that anti‐inflammatory effects are due to inhibition of mouse tumour necrosis factor (TNF)‐α. However, the mechanism of action in mice remains unclear. In this study, the binding specificity of IFX f...

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Veröffentlicht in:	Clinical and experimental immunology 2017-02, Vol.187 (2), p.225-233
Hauptverfasser:	Assas, B. M., Levison, S. E., Little, M., England, H., Battrick, L., Bagnall, J., McLaughlin, J. T., Paszek, P., Else, K. J., Pennock, J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Blocking - therapeutic use antibody Apoptosis - drug effects Cells, Cultured Colitis - drug therapy Colitis - parasitology Epitopes Fibroblasts - drug effects Fibroblasts - physiology Humans inflammation Infliximab - pharmacology Infliximab - therapeutic use macrophage Macrophages - drug effects Macrophages - parasitology Male Mice Mice, Inbred AKR Mice, Knockout mucosa Original Protein Binding Trichuriasis - drug therapy Trichuris - immunology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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