BPA‐toxicity via superoxide anion overload and a deficit in β‐catenin signaling in human bone mesenchymal stem cells

ABSTRACT Bisphenol A (BPA), used in the manufacture of products based on polycarbonate plastics and epoxy resins, is well known as an endocrine‐disrupting monomer. In the current study, BPA increased cytotoxicity in hBMSCs in a dose‐ and time‐dependent manner, concomitantly with increased lipid pero...

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Veröffentlicht in:	Environmental toxicology 2017-01, Vol.32 (1), p.344-352
Hauptverfasser:	Leem, Yea‐Hyun, Oh, Seikwan, Kang, Hong‐Je, Kim, Jung‐Hwa, Yoon, Juno, Chang, Jae‐Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol - pharmacology Antioxidants - metabolism Benzhydryl Compounds - toxicity beta Catenin - metabolism bisphenol A Bone Marrow Cells - cytology Catalase - metabolism Cells, Cultured Cyclin D1 - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism GSK3β human bone mesenchymal stem cells Humans Lipid Peroxidation - drug effects Lithium Chloride - pharmacology Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism MnTBAP Phenols - toxicity Signal Transduction - drug effects superoxide dismutase Superoxide Dismutase - metabolism Superoxides - metabolism β‐catenin
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