Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX

Summary Infections due to multidrug‐resistant bacteria represent a major global health challenge. To combat this problem, new antibiotics are urgently needed and some plant‐associated bacteria are a promising source. The rhizobacterium Serratia plymuthica A153 produces several bioactive secondary me...

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Veröffentlicht in:	Environmental microbiology 2016-11, Vol.18 (11), p.3635-3650
Hauptverfasser:	Matilla, Miguel A., Nogellova, Veronika, Morel, Bertrand, Krell, Tino, Salmond, George P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - antagonists & inhibitors Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Anti-Bacterial Agents - metabolism Antibiotics Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biosynthesis Gene expression Gene Expression Regulation, Bacterial - drug effects Genomes Host Factor 1 Protein - genetics Host Factor 1 Protein - metabolism Macrolides - metabolism Multigene Family Mutagenesis Polyamines - metabolism Polyenes - metabolism Pyrroles - metabolism Serratia - enzymology Serratia - genetics Serratia - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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