Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells

Leukemia cells are highly dependent on glucose and glutamine as bioenergetic and biosynthetic fuels. Inhibition of the metabolism of glucose but also of glutamine is thus proposed as a therapeutic modality to block leukemia cell growth. Since glucose also supports protein glycosylation, we wondered...

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Veröffentlicht in:	Oncotarget 2016-07, Vol.7 (29), p.46371-46383
Hauptverfasser:	Polet, Florence, Martherus, Ruben, Corbet, Cyril, Pinto, Adan, Feron, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System ASC - metabolism Cell Line, Tumor Cell Proliferation - physiology Glucose - metabolism Glutamine - metabolism Glycosylation Humans Large Neutral Amino Acid-Transporter 1 - biosynthesis Leukemia - metabolism Minor Histocompatibility Antigens - metabolism Research Paper Up-Regulation
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