Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites

Multiple kelch13 alleles conferring artemisinin resistance (ART-R) are currently spreading through Southeast Asian malaria parasite populations, providing a unique opportunity to observe an ongoing soft selective sweep, investigate why resistance alleles have evolved multiple times and determine fun...

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Veröffentlicht in:	Molecular biology and evolution 2017-01, Vol.34 (1), p.131-144
Hauptverfasser:	Anderson, Timothy J.C., Nair, Shalini, McDew-White, Marina, Cheeseman, Ian H., Nkhoma, Standwell, Bilgic, Fatma, McGready, Rose, Ashley, Elizabeth, Pyae Phyo, Aung, White, Nicholas J., Nosten, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Animals Antimalarials - pharmacology Artemisinins - pharmacology Discoveries Drug Resistance Gene Frequency Genetics, Population Humans Malaria, Falciparum - blood Malaria, Falciparum - parasitology Mutation Mutation Rate Plasmodium falciparum - genetics Polymorphism, Single Nucleotide Protozoan Proteins - genetics Selection, Genetic Sequence Analysis, DNA Thailand
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