The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea
The mu-opioid receptor ( OPRM1 ) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions,...
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| Veröffentlicht in: | Scientific reports 2017-01, Vol.7 (1), p.39906-39906, Article 39906 |
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| creator | Wei, Shyh-Yuh Chen, Li-Fen Lin, Ming-Wei Li, Wei-Chi Low, Intan Yang, Ching-Ju Chao, Hsiang-Tai Hsieh, Jen-Chuen |
| description | The mu-opioid receptor (
OPRM1
) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the
OPRM1
A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This
OPRM1
A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience. |
| doi_str_mv | 10.1038/srep39906 |
| format | Article |
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OPRM1
) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the
OPRM1
A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This
OPRM1
A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep39906</identifier><identifier>PMID: 28057931</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/36 ; 59/57 ; 631/378/2583 ; 631/378/3920 ; 692/1807/410/2610 ; Alleles ; Analgesics ; Cortex (cingulate) ; Functional magnetic resonance imaging ; Genetics ; Genotyping ; Homozygotes ; Humanities and Social Sciences ; Hypnosis ; Memory ; Menstruation ; multidisciplinary ; Narcotics ; Neck ; Neural networks ; Neuroimaging ; Opioid receptors (type mu) ; Pain ; Periaqueductal gray area ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2017-01, Vol.7 (1), p.39906-39906, Article 39906</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-a1a74f72450c886e5185ffb28af487daa5f572337d315ee4475ab93778960b5a3</citedby><cites>FETCH-LOGICAL-c438t-a1a74f72450c886e5185ffb28af487daa5f572337d315ee4475ab93778960b5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28057931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Shyh-Yuh</creatorcontrib><creatorcontrib>Chen, Li-Fen</creatorcontrib><creatorcontrib>Lin, Ming-Wei</creatorcontrib><creatorcontrib>Li, Wei-Chi</creatorcontrib><creatorcontrib>Low, Intan</creatorcontrib><creatorcontrib>Yang, Ching-Ju</creatorcontrib><creatorcontrib>Chao, Hsiang-Tai</creatorcontrib><creatorcontrib>Hsieh, Jen-Chuen</creatorcontrib><title>The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The mu-opioid receptor (
OPRM1
) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the
OPRM1
A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This
OPRM1
A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.</description><subject>59/36</subject><subject>59/57</subject><subject>631/378/2583</subject><subject>631/378/3920</subject><subject>692/1807/410/2610</subject><subject>Alleles</subject><subject>Analgesics</subject><subject>Cortex (cingulate)</subject><subject>Functional magnetic resonance imaging</subject><subject>Genetics</subject><subject>Genotyping</subject><subject>Homozygotes</subject><subject>Humanities and Social Sciences</subject><subject>Hypnosis</subject><subject>Memory</subject><subject>Menstruation</subject><subject>multidisciplinary</subject><subject>Narcotics</subject><subject>Neck</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Opioid receptors (type mu)</subject><subject>Pain</subject><subject>Periaqueductal gray area</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkc1u1DAUhS0EolXpghdAltgA0oB_4tjeIFUVtJWKilBZR57kZuIqsYOdtOQ9eGAumulogGwc-Xw-PteHkJecvedMmg85wSitZeUTcixYoVZCCvH04P-InOZ8x_BTwhbcPidHwjClreTH5NdtB_Tm67cvnJ5xbi7oGPtliGnsfB7oEJu5dxNkOiHWQK4hND5s6Oh8eFRjWmhe8gQDbWOiHol738yu31Lwc4TkIdSAEl3ijMcf4gCBPvipo2Pyg0OHZsm4F1PqwL0gz1rXZzjdrSfk--dPt-eXq-ubi6vzs-tVXUgzrRx3umi1KBSrjSlBcaPadi2MawujG-dUq7SQUjeSK4Ci0MqtrdTa2JKtlZMn5OPWd5zXAzQ43JRcX-0iVdH56m8l-K7axPtKCV7KUqPBm51Bij9myFM1eHyjvncB4pwrDFQqK6xhiL7-B72Lcwo4HlLWFhbHkEi93VJ1ihmbbfdhOKv-1F3t60b21WH6PflYLgLvtkBGKWwgHVz5n9tvoBG28A</recordid><startdate>20170106</startdate><enddate>20170106</enddate><creator>Wei, Shyh-Yuh</creator><creator>Chen, Li-Fen</creator><creator>Lin, Ming-Wei</creator><creator>Li, Wei-Chi</creator><creator>Low, Intan</creator><creator>Yang, Ching-Ju</creator><creator>Chao, Hsiang-Tai</creator><creator>Hsieh, Jen-Chuen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170106</creationdate><title>The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea</title><author>Wei, Shyh-Yuh ; Chen, Li-Fen ; Lin, Ming-Wei ; Li, Wei-Chi ; Low, Intan ; Yang, Ching-Ju ; Chao, Hsiang-Tai ; Hsieh, Jen-Chuen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-a1a74f72450c886e5185ffb28af487daa5f572337d315ee4475ab93778960b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>59/36</topic><topic>59/57</topic><topic>631/378/2583</topic><topic>631/378/3920</topic><topic>692/1807/410/2610</topic><topic>Alleles</topic><topic>Analgesics</topic><topic>Cortex (cingulate)</topic><topic>Functional magnetic resonance imaging</topic><topic>Genetics</topic><topic>Genotyping</topic><topic>Homozygotes</topic><topic>Humanities and Social Sciences</topic><topic>Hypnosis</topic><topic>Memory</topic><topic>Menstruation</topic><topic>multidisciplinary</topic><topic>Narcotics</topic><topic>Neck</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Opioid receptors (type mu)</topic><topic>Pain</topic><topic>Periaqueductal gray area</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Shyh-Yuh</creatorcontrib><creatorcontrib>Chen, Li-Fen</creatorcontrib><creatorcontrib>Lin, Ming-Wei</creatorcontrib><creatorcontrib>Li, Wei-Chi</creatorcontrib><creatorcontrib>Low, Intan</creatorcontrib><creatorcontrib>Yang, Ching-Ju</creatorcontrib><creatorcontrib>Chao, Hsiang-Tai</creatorcontrib><creatorcontrib>Hsieh, Jen-Chuen</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Shyh-Yuh</au><au>Chen, Li-Fen</au><au>Lin, Ming-Wei</au><au>Li, Wei-Chi</au><au>Low, Intan</au><au>Yang, Ching-Ju</au><au>Chao, Hsiang-Tai</au><au>Hsieh, Jen-Chuen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-01-06</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>39906</spage><epage>39906</epage><pages>39906-39906</pages><artnum>39906</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The mu-opioid receptor (
OPRM1
) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the
OPRM1
A118G polymorphisms could provide a possible explanation for the differences in pain experience. Sixty-one subjects with PDM and 65 controls participated in the current study of resting-state functional magnetic resonance imaging (fMRI) during the menstruation and peri-ovulatory phases; blood samples were taken for genotyping. We studied 3 aspects of pain experience, namely, mnemonic pain (recalled overall menstrual pain), present pain (spontaneous menstrual pain), and experimental pain (thermal pain) intensities. We report that G allele carriers, in comparison to AA homozygotes, exhibited functional hypo-connectivity between the anterior cingulate cortex (ACC) and periaqueductal gray (PAG). Furthermore, G allele carriers lost the correlation with spontaneous pain experience and exhibited dysfunctional DPMS by means of PAG-seeded FC dynamics. This
OPRM1
A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28057931</pmid><doi>10.1038/srep39906</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 59/36 59/57 631/378/2583 631/378/3920 692/1807/410/2610 Alleles Analgesics Cortex (cingulate) Functional magnetic resonance imaging Genetics Genotyping Homozygotes Humanities and Social Sciences Hypnosis Memory Menstruation multidisciplinary Narcotics Neck Neural networks Neuroimaging Opioid receptors (type mu) Pain Periaqueductal gray area Science Science (multidisciplinary) |
| title | The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea |
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