The Thiophene "Sigma-Hole" as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove

In spite of its importance in cell function, targeting DNA is under‐represented in the design of small molecules. A barrier to progress in this area is the lack of a variety of modules that recognize G⋅C base pairs (bp) in DNA sequences. To overcome this barrier, an entirely new design concept for m...

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Veröffentlicht in:	Chemistry : a European journal 2016-10, Vol.22 (43), p.15404-15412
Hauptverfasser:	Guo, Pu, Paul, Ananya, Kumar, Arvind, Farahat, Abdelbasset A., Kumar, Dhiraj, Wang, Siming, Boykin, David W., Wilson, W. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing bioinformatics biosensors Cations - chemistry DNA - chemistry DNA minor groove Hydrogen Bonding Models, Molecular N-methylbenzimidazole thiophene sigma-hole Static Electricity Thiophenes - chemistry
Online-Zugang:	Volltext
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