Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy
Summary Objective Interictal [18F]fluorodeoxyglucose–positron emission tomography (FDG‐PET) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations (iHFOs) shown to be a relevant marker of t...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2016-12, Vol.57 (12), p.2045-2055 |
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| container_title | Epilepsia (Copenhagen) |
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| creator | Lamarche, Florence Job, Anne‐Sophie Deman, Pierre Bhattacharjee, Manik Hoffmann, Dominique Gallazzini‐Crépin, Céline Bouvard, Sandrine Minotti, Lorella Kahane, Philippe David, Olivier |
| description | Summary
Objective
Interictal [18F]fluorodeoxyglucose–positron emission tomography (FDG‐PET) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations (iHFOs) shown to be a relevant marker of the seizure‐onset zone.
Methods
We studied the correlation between FDG‐PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo‐electroencephalography (SEEG).
Results
At the group level, we found a significant correlation between iHFOs and FDG‐PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG‐PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
Significance
This finding suggests that interictal FDG‐PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure‐onset zone. |
| doi_str_mv | 10.1111/epi.13592 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5214566</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1841801243</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4152-160d030e7f3d1a78807573a07f9f6cf139b46688f661676ac76fa68f9272d0ad3</originalsourceid><addsrcrecordid>eNp1kUFPHCEYhompqVvbg3_AcKyHURhmgLmYmO24NTHRRHsm7AzsYmZgBLab8eRP8Df2l4jd1ehBLhx48nzfywvAAUbHOJ0TNZhjTMoq3wETXOY8w5iyL2CCECZZVXK0B76FcIcQYpSRr2AvZ5xixvgEPEyd96qT0TgLnYbnv2b_Hp-u61u4HAfXqyjnrjOhh9K28KauZzAN69QQ3UJZ05g4wl4Og7ELaCwckkfZGODaxCVs_WqRZF4FE6K0EWrXyG4rCON3sKtlF9SP7b0P_pzXt9Pf2eXV7GJ6dpk1RQqTYYpaRJBimrRYMs4RKxmRiOlK00ZjUs0LSjnXlKbUVDaMakm5rnKWt0i2ZB-cbrzDat6rtkkLetmJwZte-lE4acTHF2uWYuH-ijLHRUlpEvzcCry7X6kQRW9Co7pOWuVWQWBeYI5wXpCEHm3QxrsQvNJvYzASL12JlF787yqxh-_3eiNfy0nAyQZYpw8bPzeJ-vpio3wG7oqiPA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1841801243</pqid></control><display><type>article</type><title>Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Lamarche, Florence ; Job, Anne‐Sophie ; Deman, Pierre ; Bhattacharjee, Manik ; Hoffmann, Dominique ; Gallazzini‐Crépin, Céline ; Bouvard, Sandrine ; Minotti, Lorella ; Kahane, Philippe ; David, Olivier</creator><creatorcontrib>Lamarche, Florence ; Job, Anne‐Sophie ; Deman, Pierre ; Bhattacharjee, Manik ; Hoffmann, Dominique ; Gallazzini‐Crépin, Céline ; Bouvard, Sandrine ; Minotti, Lorella ; Kahane, Philippe ; David, Olivier</creatorcontrib><description>Summary
Objective
Interictal [18F]fluorodeoxyglucose–positron emission tomography (FDG‐PET) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations (iHFOs) shown to be a relevant marker of the seizure‐onset zone.
Methods
We studied the correlation between FDG‐PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo‐electroencephalography (SEEG).
Results
At the group level, we found a significant correlation between iHFOs and FDG‐PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG‐PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
Significance
This finding suggests that interictal FDG‐PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure‐onset zone.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/epi.13592</identifier><identifier>PMID: 27861778</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Adolescent ; Adult ; Brain Mapping ; Child ; Electrodes, Implanted ; Electroencephalography ; Epilepsies, Partial - diagnostic imaging ; Epilepsies, Partial - physiopathology ; Epileptogenicity map ; FDG‐PET ; Female ; Fluorodeoxyglucose F18 - metabolism ; Focal epilepsy ; Full‐Length Original Research ; Humans ; Ictal HFO ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Positron-Emission Tomography ; SEEG ; Statistics as Topic ; Young Adult</subject><ispartof>Epilepsia (Copenhagen), 2016-12, Vol.57 (12), p.2045-2055</ispartof><rights>2016 The Authors. published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.</rights><rights>2016 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4152-160d030e7f3d1a78807573a07f9f6cf139b46688f661676ac76fa68f9272d0ad3</citedby><cites>FETCH-LOGICAL-c4152-160d030e7f3d1a78807573a07f9f6cf139b46688f661676ac76fa68f9272d0ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fepi.13592$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fepi.13592$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27861778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamarche, Florence</creatorcontrib><creatorcontrib>Job, Anne‐Sophie</creatorcontrib><creatorcontrib>Deman, Pierre</creatorcontrib><creatorcontrib>Bhattacharjee, Manik</creatorcontrib><creatorcontrib>Hoffmann, Dominique</creatorcontrib><creatorcontrib>Gallazzini‐Crépin, Céline</creatorcontrib><creatorcontrib>Bouvard, Sandrine</creatorcontrib><creatorcontrib>Minotti, Lorella</creatorcontrib><creatorcontrib>Kahane, Philippe</creatorcontrib><creatorcontrib>David, Olivier</creatorcontrib><title>Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Objective
Interictal [18F]fluorodeoxyglucose–positron emission tomography (FDG‐PET) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations (iHFOs) shown to be a relevant marker of the seizure‐onset zone.
Methods
We studied the correlation between FDG‐PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo‐electroencephalography (SEEG).
Results
At the group level, we found a significant correlation between iHFOs and FDG‐PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG‐PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
Significance
This finding suggests that interictal FDG‐PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure‐onset zone.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>Epilepsies, Partial - diagnostic imaging</subject><subject>Epilepsies, Partial - physiopathology</subject><subject>Epileptogenicity map</subject><subject>FDG‐PET</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Focal epilepsy</subject><subject>Full‐Length Original Research</subject><subject>Humans</subject><subject>Ictal HFO</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography</subject><subject>SEEG</subject><subject>Statistics as Topic</subject><subject>Young Adult</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kUFPHCEYhompqVvbg3_AcKyHURhmgLmYmO24NTHRRHsm7AzsYmZgBLab8eRP8Df2l4jd1ehBLhx48nzfywvAAUbHOJ0TNZhjTMoq3wETXOY8w5iyL2CCECZZVXK0B76FcIcQYpSRr2AvZ5xixvgEPEyd96qT0TgLnYbnv2b_Hp-u61u4HAfXqyjnrjOhh9K28KauZzAN69QQ3UJZ05g4wl4Og7ELaCwckkfZGODaxCVs_WqRZF4FE6K0EWrXyG4rCON3sKtlF9SP7b0P_pzXt9Pf2eXV7GJ6dpk1RQqTYYpaRJBimrRYMs4RKxmRiOlK00ZjUs0LSjnXlKbUVDaMakm5rnKWt0i2ZB-cbrzDat6rtkkLetmJwZte-lE4acTHF2uWYuH-ijLHRUlpEvzcCry7X6kQRW9Co7pOWuVWQWBeYI5wXpCEHm3QxrsQvNJvYzASL12JlF787yqxh-_3eiNfy0nAyQZYpw8bPzeJ-vpio3wG7oqiPA</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Lamarche, Florence</creator><creator>Job, Anne‐Sophie</creator><creator>Deman, Pierre</creator><creator>Bhattacharjee, Manik</creator><creator>Hoffmann, Dominique</creator><creator>Gallazzini‐Crépin, Céline</creator><creator>Bouvard, Sandrine</creator><creator>Minotti, Lorella</creator><creator>Kahane, Philippe</creator><creator>David, Olivier</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201612</creationdate><title>Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy</title><author>Lamarche, Florence ; Job, Anne‐Sophie ; Deman, Pierre ; Bhattacharjee, Manik ; Hoffmann, Dominique ; Gallazzini‐Crépin, Céline ; Bouvard, Sandrine ; Minotti, Lorella ; Kahane, Philippe ; David, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4152-160d030e7f3d1a78807573a07f9f6cf139b46688f661676ac76fa68f9272d0ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Brain Mapping</topic><topic>Child</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>Epilepsies, Partial - diagnostic imaging</topic><topic>Epilepsies, Partial - physiopathology</topic><topic>Epileptogenicity map</topic><topic>FDG‐PET</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Focal epilepsy</topic><topic>Full‐Length Original Research</topic><topic>Humans</topic><topic>Ictal HFO</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography</topic><topic>SEEG</topic><topic>Statistics as Topic</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamarche, Florence</creatorcontrib><creatorcontrib>Job, Anne‐Sophie</creatorcontrib><creatorcontrib>Deman, Pierre</creatorcontrib><creatorcontrib>Bhattacharjee, Manik</creatorcontrib><creatorcontrib>Hoffmann, Dominique</creatorcontrib><creatorcontrib>Gallazzini‐Crépin, Céline</creatorcontrib><creatorcontrib>Bouvard, Sandrine</creatorcontrib><creatorcontrib>Minotti, Lorella</creatorcontrib><creatorcontrib>Kahane, Philippe</creatorcontrib><creatorcontrib>David, Olivier</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamarche, Florence</au><au>Job, Anne‐Sophie</au><au>Deman, Pierre</au><au>Bhattacharjee, Manik</au><au>Hoffmann, Dominique</au><au>Gallazzini‐Crépin, Céline</au><au>Bouvard, Sandrine</au><au>Minotti, Lorella</au><au>Kahane, Philippe</au><au>David, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2016-12</date><risdate>2016</risdate><volume>57</volume><issue>12</issue><spage>2045</spage><epage>2055</epage><pages>2045-2055</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><abstract>Summary
Objective
Interictal [18F]fluorodeoxyglucose–positron emission tomography (FDG‐PET) is used in the presurgical evaluation of patients with drug‐resistant focal epilepsy. We aimed at clarifying its relationships with ictal high‐frequency oscillations (iHFOs) shown to be a relevant marker of the seizure‐onset zone.
Methods
We studied the correlation between FDG‐PET and epileptogenicity maps in an unselected series of 37 successive patients having been explored with stereo‐electroencephalography (SEEG).
Results
At the group level, we found a significant correlation between iHFOs and FDG‐PET interictal hypometabolism only in cases of temporal lobe epilepsy. This correlation was found with HFOs, and the same comparison between FDG‐PET and ictal SEEG power of lower frequencies during the same epochs did not show the same significance.
Significance
This finding suggests that interictal FDG‐PET and ictal HFOs may share common underlying pathophysiologic mechanisms of ictogenesis in temporal lobe epilepsy, and combining both features may help to identify the seizure‐onset zone.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>27861778</pmid><doi>10.1111/epi.13592</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-9580 |
| ispartof | Epilepsia (Copenhagen), 2016-12, Vol.57 (12), p.2045-2055 |
| issn | 0013-9580 1528-1167 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5214566 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Brain Mapping Child Electrodes, Implanted Electroencephalography Epilepsies, Partial - diagnostic imaging Epilepsies, Partial - physiopathology Epileptogenicity map FDG‐PET Female Fluorodeoxyglucose F18 - metabolism Focal epilepsy Full‐Length Original Research Humans Ictal HFO Image Processing, Computer-Assisted Male Middle Aged Positron-Emission Tomography SEEG Statistics as Topic Young Adult |
| title | Correlation of FDG‐PET hypometabolism and SEEG epileptogenicity mapping in patients with drug‐resistant focal epilepsy |
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