Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass
Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from t...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-5 |
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| creator | Kıbar, Kurtuluş Ozan, Gonca Doğan, Ayşe Türker, Fevzi Sarper Erışır, Mine |
| description | Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results. A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods. GSH levels and CAT activities increased significantly in early postoperative and postoperative periods. Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period. Conclusion. Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed. |
| doi_str_mv | 10.1155/2016/1783728 |
| format | Article |
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The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results. A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods. GSH levels and CAT activities increased significantly in early postoperative and postoperative periods. Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period. Conclusion. Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2016/1783728</identifier><identifier>PMID: 28101295</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Anesthesia ; Antioxidants ; Antioxidants - metabolism ; Cardiopulmonary Bypass ; Catalase - blood ; Coronary vessels ; Female ; Free radicals ; Free radicals (Chemistry) ; Free Radicals - metabolism ; Glutathione Peroxidase - blood ; Health aspects ; Heart ; Heart surgery ; Humans ; Intervention ; Ischemia ; Lipid peroxidation ; Male ; Malondialdehyde - blood ; Metabolism ; Middle Aged ; Oxidative Stress ; Pathogenesis ; Postoperative period ; Quality of life ; Reactive Oxygen Species - metabolism ; Rodents ; Studies ; Superoxide Dismutase - blood ; Surgery</subject><ispartof>Oxidative medicine and cellular longevity, 2016-01, Vol.2016 (2016), p.1-5</ispartof><rights>Copyright © 2016 Fevzi Sarper Türker et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Fevzi Sarper Türker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c0981257b1493487c6af2eb46bf0726c79fdedd1be837e272582c486e2ff3c333</citedby><cites>FETCH-LOGICAL-c499t-c0981257b1493487c6af2eb46bf0726c79fdedd1be837e272582c486e2ff3c333</cites><orcidid>0000-0002-5360-4671 ; 0000-0002-4235-3942</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28101295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khaper, Neelam</contributor><creatorcontrib>Kıbar, Kurtuluş</creatorcontrib><creatorcontrib>Ozan, Gonca</creatorcontrib><creatorcontrib>Doğan, Ayşe</creatorcontrib><creatorcontrib>Türker, Fevzi Sarper</creatorcontrib><creatorcontrib>Erışır, Mine</creatorcontrib><title>Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results. A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods. GSH levels and CAT activities increased significantly in early postoperative and postoperative periods. Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period. Conclusion. Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed.</description><subject>Aged</subject><subject>Anesthesia</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Cardiopulmonary Bypass</subject><subject>Catalase - blood</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Free radicals</subject><subject>Free radicals (Chemistry)</subject><subject>Free Radicals - metabolism</subject><subject>Glutathione Peroxidase - blood</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Intervention</subject><subject>Ischemia</subject><subject>Lipid peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Pathogenesis</subject><subject>Postoperative period</subject><subject>Quality of life</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>Superoxide Dismutase - blood</subject><subject>Surgery</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1v1DAQxSNERUvhxhlZ4oIES_2ZxBekZdXSSisVAT1bjjNJXCX2Yicty4G_HUe7bIETp7HGP715My_LXhD8jhAhzigm-RkpSlbQ8lF2QiSnCywlf3x4Y3ycPY3xFuOcUU6eZMe0JJhQKU6yn6tOuxaQdegiAKDPurZG90i7Gi3daP13W2s3onP3YzsAWsMd9HGmxw7QJz1acGNEN66G0HrrWnS9AYcuQYcRfZlCC2GL7u3YoZUOtfWbqR-806n5YbvRMT7LjhrdR3i-r6fZzcX519XlYn398Wq1XC8Ml3JcGCxLQkVRES4ZLwuT64ZCxfOqwQXNTSGbGuqaVJDOALSgoqSGlznQpmGGMXaavd_pbqZqgNok10H3ahPskMwor636-8fZTrX-TglKuGAyCbzeCwT_bYI4qsFGA32vHfgpKlLmRBRCFPOsV_-gt34KLq03UzQlwCR_oFrdg7Ku8WmumUXVUghRCsyxSNTbHWWCjzFAc7BMsJrjV3P8ah9_wl_-ueYB_p13At7sgM66Wt_b_5SDxECjH2hCWJ7u8guFuMFk</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kıbar, Kurtuluş</creator><creator>Ozan, Gonca</creator><creator>Doğan, Ayşe</creator><creator>Türker, Fevzi Sarper</creator><creator>Erışır, Mine</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5360-4671</orcidid><orcidid>https://orcid.org/0000-0002-4235-3942</orcidid></search><sort><creationdate>20160101</creationdate><title>Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass</title><author>Kıbar, Kurtuluş ; Ozan, Gonca ; Doğan, Ayşe ; Türker, Fevzi Sarper ; Erışır, Mine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-c0981257b1493487c6af2eb46bf0726c79fdedd1be837e272582c486e2ff3c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Anesthesia</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Cardiopulmonary Bypass</topic><topic>Catalase - blood</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Free radicals</topic><topic>Free radicals (Chemistry)</topic><topic>Free Radicals - metabolism</topic><topic>Glutathione Peroxidase - blood</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Intervention</topic><topic>Ischemia</topic><topic>Lipid peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Pathogenesis</topic><topic>Postoperative period</topic><topic>Quality of life</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Rodents</topic><topic>Studies</topic><topic>Superoxide Dismutase - blood</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kıbar, Kurtuluş</creatorcontrib><creatorcontrib>Ozan, Gonca</creatorcontrib><creatorcontrib>Doğan, Ayşe</creatorcontrib><creatorcontrib>Türker, Fevzi Sarper</creatorcontrib><creatorcontrib>Erışır, Mine</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kıbar, Kurtuluş</au><au>Ozan, Gonca</au><au>Doğan, Ayşe</au><au>Türker, Fevzi Sarper</au><au>Erışır, Mine</au><au>Khaper, Neelam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Objective. The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods. Methods. A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively. Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined. Results. A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods. GSH levels and CAT activities increased significantly in early postoperative and postoperative periods. Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period. Conclusion. Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28101295</pmid><doi>10.1155/2016/1783728</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5360-4671</orcidid><orcidid>https://orcid.org/0000-0002-4235-3942</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anesthesia Antioxidants Antioxidants - metabolism Cardiopulmonary Bypass Catalase - blood Coronary vessels Female Free radicals Free radicals (Chemistry) Free Radicals - metabolism Glutathione Peroxidase - blood Health aspects Heart Heart surgery Humans Intervention Ischemia Lipid peroxidation Male Malondialdehyde - blood Metabolism Middle Aged Oxidative Stress Pathogenesis Postoperative period Quality of life Reactive Oxygen Species - metabolism Rodents Studies Superoxide Dismutase - blood Surgery |
| title | Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass |
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